A new derivatization reagent for LC-MS/MS screening of potential genotoxic alkylation compounds

Journal of Pharmaceutical and Biomedical Analysis

Volumn 74, Issue , 2013, Pages 133-140

  van Wijk, A M ^a   Niederlander H A G ^a   Siebum, A H G ^a   Vervaart, M A T ^a   de Jong, G J ^b  

^a Chemical Design and Synthesis Unit   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Alkyl halides; Alkyl sulfonates; Derivatization; Genotoxic components; Mass spectrometry; Neutral loss

Indexed keywords

4 DIMETHYLAMINOPYRIDINE; ALKYL SULFONATE; BUTYL 1 (PYRIDIN 4 YL)PIPERIDINE 4 CARBOXYLATE; CARBOXYLIC ACID DERIVATIVE; HALIDE; SULFONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ACCURACY; ALKYLATION; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DERIVATIZATION; FRAGMENTATION REACTION; GENOTOXICITY; HYDROPHILIC INTERACTION CHROMATOGRAPHY; PARTICLE SIZE; PRIORITY JOURNAL; REACTION TIME; SCREENING; SYNTHESIS; TANDEM MASS SPECTROMETRY;

4-AMINOPYRIDINE; ALKYLATION; CHROMATOGRAPHY, LIQUID; DRUG EVALUATION, PRECLINICAL; MUTAGENS; TANDEM MASS SPECTROMETRY;

EID: 84871894282     PISSN: 07317085     EISSN: 1873264X     Source Type: Journal    
DOI: 10.1016/j.jpba.2012.10.004     Document Type: Article

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