Trapping 4-fluorobenzyl chloride in human plasma with chemical derivatization followed by quantitative bioanalysis using high-performance liquid chromatography/tandem mass spectrometry

Rapid Communications in Mass Spectrometry

Volumn 19, Issue 6, 2005, Pages 759-766

  Yang, Eric ^a   Wang, Sherry ^a   Bowen, Chester ^a   Kratz, John ^a   Cyronak, Matthew J ^a   Dunbar, Jacob R ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHLORINE COMPOUNDS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PHASE SEPARATION; PLASMA (HUMAN);

4-DIMETHYLAMINOPYRIDINE; BIOANALYTICAL METHODS; CHEMICAL DERIVATIZATION; CONTROL SAMPLES; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; HPLC-MS-MS; HUMAN PLASMAS; PLASMA SAMPLES; QUANTITATIVE BIO-ANALYSIS; SOLID-PHASE EXTRACTION;

MASS SPECTROMETRY;

4 DIMETHYLAMINOPYRIDINE; 4 FLUOROBENZYL CHLORIDE; AMINE; BENZYL CHLORIDE; SILICON DIOXIDE; SILVER NITRATE; UNCLASSIFIED DRUG;

ARTICLE; CATALYST; CATION EXCHANGE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DERIVATIZATION; DNA ADDUCT; ELECTRON CAPTURE DETECTION; ELECTROSPRAY MASS SPECTROMETRY; GAS CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; INCUBATION TIME; PLASMA; QUALITY CONTROL; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; THERMOSTABILITY;

EID: 14844320102     PISSN: 09514198     EISSN: None     Source Type: Journal    
DOI: 10.1002/rcm.1849     Document Type: Article

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