메뉴 건너뛰기




Volumn 5, Issue 1, 2012, Pages 11-19

Arginine deprivation therapy for malignant melanoma

Author keywords

Arginine deprivation; Argininosuccinate synthetase; Melanoma

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; ANTINEOPLASTIC AGENT; ARGINASE; ARGININE; ARGININE DECARBOXYLASE; ARGININE DEIMINASE; CANAVANINE; CISPLATIN; COBALT SUBSTITUTED PEGYLATED RECOMBINANT HUMAN ARGINASE; MACROGOL; PEGYLATED RECOMBINANT HUMAN ARGINASE; RECOMBINANT HUMAN ARGINASE; RECOMBINANT TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UREA;

EID: 84871890551     PISSN: None     EISSN: 11791438     Source Type: Journal    
DOI: 10.2147/CPAA.S37350     Document Type: Review
Times cited : (43)

References (50)
  • 1
    • 0035403337 scopus 로고    scopus 로고
    • Epidemiology, etiology, and control of melanoma
    • Weinstock MA. Epidemiology, etiology, and control of melanoma. Med Health R I. 2001;84(7):234-236.
    • (2001) Med Health R I , vol.84 , Issue.7 , pp. 234-236
    • Weinstock, M.A.1
  • 3
    • 74949143594 scopus 로고    scopus 로고
    • Final version of 2009AJCC melanoma staging and classification
    • Balch CM, Gershenwald JE, Soong SJ, et al. Final version of 2009AJCC melanoma staging and classification. J Clin Oncol. 2009;27(36):6199-6206.
    • (2009) J Clin Oncol , vol.27 , Issue.36 , pp. 6199-6206
    • Balch, C.M.1    Gershenwald, J.E.2    Soong, S.J.3
  • 4
    • 4344656396 scopus 로고    scopus 로고
    • Management of cutaneous melanoma
    • Tsao H, Atkins MB, Sober AJ. Management of cutaneous melanoma. N Engl J Med. 2004;351(10):998-1012.
    • (2004) N Engl J Med , vol.351 , Issue.10 , pp. 998-1012
    • Tsao, H.1    Atkins, M.B.2    Sober, A.J.3
  • 5
    • 0024426529 scopus 로고
    • Experience with the use of high-dose interleukin-2in the treatment of 652 cancer patients
    • Rosenberg SA, Lotze MT, Yang JC, et al. Experience with the use of high-dose interleukin-2in the treatment of 652 cancer patients. Ann Surg. 1989;210(4):474-484.
    • (1989) Ann Surg , vol.210 , Issue.4 , pp. 474-484
    • Rosenberg, S.A.1    Lotze, M.T.2    Yang, J.C.3
  • 6
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, et al. High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: analysis of 270 patients treated between 1985 and 1993. J Clin Oncol. 1999;17(7):2105-2116.
    • (1999) J Clin Oncol , vol.17 , Issue.7 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3
  • 7
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • Hodi FS, O'Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med. 2010;363(8):711-723.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3
  • 8
    • 78249254899 scopus 로고    scopus 로고
    • BRAF, a target in melanoma: Implications for solid tumor drug development
    • Flaherty KT, McArthur G. BRAF, a target in melanoma: implications for solid tumor drug development. Cancer. 2010;116(21):4902-4913.
    • (2010) Cancer , vol.116 , Issue.21 , pp. 4902-4913
    • Flaherty, K.T.1    McArthur, G.2
  • 9
    • 77956030786 scopus 로고    scopus 로고
    • Inhibition of mutated, activated BRAF in metastatic melanoma
    • Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med. 2010;363(9):809-819.
    • (2010) N Engl J Med , vol.363 , Issue.9 , pp. 809-819
    • Flaherty, K.T.1    Puzanov, I.2    Kim, K.B.3
  • 10
    • 79959776574 scopus 로고    scopus 로고
    • BRIM-2: An open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma [abstract]
    • Ribas A, Kim KB, Schuchter LM, et al. BRIM-2: an open-label, multicenter phase II study of vemurafenib in previously treated patients with BRAF V600E mutation-positive metastatic melanoma [abstract]. J Clin Oncol. 2011;29:8509.
    • (2011) J Clin Oncol , vol.29 , pp. 8509
    • Ribas, A.1    Kim, K.B.2    Schuchter, L.M.3
  • 11
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, et al. Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med. 2011;364(26):2507-2516.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3
  • 12
    • 33644852813 scopus 로고    scopus 로고
    • Arginine: Beyond protein
    • Morris SM Jr. Arginine: beyond protein. Am J Clin Nutr. 2006;83(2):508S-512S.
    • (2006) Am J Clin Nutr , vol.83 , Issue.2
    • Morris Jr., S.M.1
  • 13
    • 0032145202 scopus 로고    scopus 로고
    • Use of L-asparaginase in childhood ALL
    • Muller HJ, Boos J. Use of L-asparaginase in childhood ALL. Crit Rev Oncol Hematol. 1998;28(2):97-113.
    • (1998) Crit Rev Oncol Hematol , vol.28 , Issue.2 , pp. 97-113
    • Muller, H.J.1    Boos, J.2
  • 14
    • 0842325861 scopus 로고    scopus 로고
    • Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: A method for identifying cancers sensitive to arginine deprivation
    • Dillon BJ, Prieto VG, Curley SA, et al. Incidence and distribution of argininosuccinate synthetase deficiency in human cancers: a method for identifying cancers sensitive to arginine deprivation. Cancer. 2004;100(4):826-833.
    • (2004) Cancer , vol.100 , Issue.4 , pp. 826-833
    • Dillon, B.J.1    Prieto, V.G.2    Curley, S.A.3
  • 15
    • 0021132808 scopus 로고
    • Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia
    • Savoca KV, Davis FF, van Es T, McCoy JR, Placzuk NC. Cancer therapy with chemically modified enzymes. II. The therapeutic effectiveness of arginase, and arginase modified by the covalent attachment of polyethylene glycol, on the taper liver tumor and the L5178Y murine leukemia. Cancer Biochem Biophys. 1984;7(3):261-268.
    • (1984) Cancer Biochem Biophys , vol.7 , Issue.3 , pp. 261-268
    • Savoca, K.V.1    Davis, F.F.2    van Es, T.3    McCoy, J.R.4    Placzuk, N.C.5
  • 16
    • 33846429217 scopus 로고    scopus 로고
    • Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion
    • Cheng PN, Lam TL, Lam WM, et al. Pegylated recombinant human arginase (rhArg-peg5,000mw) inhibits the in vitro and in vivo proliferation of human hepatocellular carcinoma through arginine depletion. Cancer Res. 2007;67(1):309-317.
    • (2007) Cancer Res , vol.67 , Issue.1 , pp. 309-317
    • Cheng, P.N.1    Lam, T.L.2    Lam, W.M.3
  • 17
    • 82555197938 scopus 로고    scopus 로고
    • Cytotoxicity of human recombinant arginase I (Co)-PEG5000in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells
    • Agrawal V, Woo JH, Mauldin JP, et al. Cytotoxicity of human recombinant arginase I (Co)-PEG5000in the presence of supplemental L-citrulline is dependent on decreased argininosuccinate synthetase expression in human cells. Anticancer Drugs. 2012;23(1):51-64.
    • (2012) Anticancer Drugs , vol.23 , Issue.1 , pp. 51-64
    • Agrawal, V.1    Woo, J.H.2    Mauldin, J.P.3
  • 18
    • 77953491512 scopus 로고    scopus 로고
    • Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma
    • Savaraj N, You M, Wu C, Wangpaichitr M, Kuo MT, Feun LG. Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma. Curr Mol Med. 2010;10(4):405-412.
    • (2010) Curr Mol Med , vol.10 , Issue.4 , pp. 405-412
    • Savaraj, N.1    You, M.2    Wu, C.3    Wangpaichitr, M.4    Kuo, M.T.5    Feun, L.G.6
  • 19
    • 84856008075 scopus 로고    scopus 로고
    • Recombinant human arginase toxicity in mice is reduced by citrulline supplementation
    • Mauldin JP, Zeinali I, Kleypas K, et al. Recombinant human arginase toxicity in mice is reduced by citrulline supplementation. Transl Oncol. 2012;5(1):26-31.
    • (2012) Transl Oncol , vol.5 , Issue.1 , pp. 26-31
    • Mauldin, J.P.1    Zeinali, I.2    Kleypas, K.3
  • 20
    • 1842450302 scopus 로고    scopus 로고
    • Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism
    • Das K, Butler GH, Kwiatkowski V, Clark AD Jr, Yadav P, Arnold E. Crystal structures of arginine deiminase with covalent reaction intermediates; implications for catalytic mechanism. Structure. 2004;12(4):657-667.
    • (2004) Structure , vol.12 , Issue.4 , pp. 657-667
    • Das, K.1    Butler, G.H.2    Kwiatkowski, V.3    Clark Jr., A.D.4    Yadav, P.5    Arnold, E.6
  • 21
    • 0029124788 scopus 로고
    • Anti-tumor activity of arginine deiminase from Mycoplasma argini and its growth-inhibitory mechanism
    • Takaku H, Matsumoto M, Misawa S, Miyazaki K. Anti-tumor activity of arginine deiminase from Mycoplasma argini and its growth-inhibitory mechanism. Jpn J Cancer Res. 1995;86(9):840-846.
    • (1995) Jpn J Cancer Res , vol.86 , Issue.9 , pp. 840-846
    • Takaku, H.1    Matsumoto, M.2    Misawa, S.3    Miyazaki, K.4
  • 22
    • 0036792124 scopus 로고    scopus 로고
    • Pegylated arginine deiminase (ADI-SS PEG20,000mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo
    • Ensor CM, Holtsberg FW, Bomalaski JS, Clark MA. Pegylated arginine deiminase (ADI-SS PEG20,000mw) inhibits human melanomas and hepatocellular carcinomas in vitro and in vivo. Cancer Res. 2002;62(19):5443-5450.
    • (2002) Cancer Res , vol.62 , Issue.19 , pp. 5443-5450
    • Ensor, C.M.1    Holtsberg, F.W.2    Bomalaski, J.S.3    Clark, M.A.4
  • 23
    • 0037161333 scopus 로고    scopus 로고
    • Poly(ethylene glycol) (PEG) conjugated arginine deiminase: Effects of PEG formulations on its pharmacological properties
    • Holtsberg FW, Ensor CM, Steiner MR, Bomalaski JS, Clark MA. Poly(ethylene glycol) (PEG) conjugated arginine deiminase: effects of PEG formulations on its pharmacological properties. J Control Release. 2002;80(1-3):259-271.
    • (2002) J Control Release , vol.80 , Issue.1-3 , pp. 259-271
    • Holtsberg, F.W.1    Ensor, C.M.2    Steiner, M.R.3    Bomalaski, J.S.4    Clark, M.A.5
  • 24
    • 0026608575 scopus 로고
    • In vivo anti-tumor activity of arginine deiminase purified from Mycoplasma arginini
    • Takaku H, Takase M, Abe S, Hayashi H, Miyazaki K. In vivo anti-tumor activity of arginine deiminase purified from Mycoplasma arginini. Int J Cancer. 1992;51(2):244-249.
    • (1992) Int J Cancer , vol.51 , Issue.2 , pp. 244-249
    • Takaku, H.1    Takase, M.2    Abe, S.3    Hayashi, H.4    Miyazaki, K.5
  • 25
    • 33747181970 scopus 로고    scopus 로고
    • Pegylated arginine deiminase: A novel anticancer enzyme agent
    • Feun L, Savaraj N. Pegylated arginine deiminase: a novel anticancer enzyme agent. Expert Opin Investig Drugs. 2006;15(7):815-822.
    • (2006) Expert Opin Investig Drugs , vol.15 , Issue.7 , pp. 815-822
    • Feun, L.1    Savaraj, N.2
  • 26
    • 79954775922 scopus 로고    scopus 로고
    • Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes
    • Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget. 2010;1(4):246-251.
    • (2010) Oncotarget , vol.1 , Issue.4 , pp. 246-251
    • Kuo, M.T.1    Savaraj, N.2    Feun, L.G.3
  • 27
    • 79952598775 scopus 로고    scopus 로고
    • Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis
    • Lam TL, Wong GK, Chow HY, et al. Recombinant human arginase inhibits the in vitro and in vivo proliferation of human melanoma by inducing cell cycle arrest and apoptosis. Pigment Cell Melanoma Res. 2011;24(2):366-376.
    • (2011) Pigment Cell Melanoma Res , vol.24 , Issue.2 , pp. 366-376
    • Lam, T.L.1    Wong, G.K.2    Chow, H.Y.3
  • 28
    • 77950003784 scopus 로고    scopus 로고
    • Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines
    • Stone EM, Glazer ES, Chantranupong L, et al. Replacing Mn(2+) with Co(2+) in human arginase i enhances cytotoxicity toward l-arginine auxotrophic cancer cell lines. ACS Chem Biol. 2010;5(3):333-342.
    • (2010) ACS Chem Biol , vol.5 , Issue.3 , pp. 333-342
    • Stone, E.M.1    Glazer, E.S.2    Chantranupong, L.3
  • 29
    • 79957919927 scopus 로고    scopus 로고
    • Bioengineered human arginase I with enhanced activity and stability controls hepatocellular and pancreatic carcinoma xenografts
    • Glazer ES, Stone EM, Zhu C, Massey KL, Hamir AN, Curley SA. Bioengineered human arginase I with enhanced activity and stability controls hepatocellular and pancreatic carcinoma xenografts. Transl Oncol. 2011;4(3):138-146.
    • (2011) Transl Oncol , vol.4 , Issue.3 , pp. 138-146
    • Glazer, E.S.1    Stone, E.M.2    Zhu, C.3    Massey, K.L.4    Hamir, A.N.5    Curley, S.A.6
  • 30
    • 82555182014 scopus 로고    scopus 로고
    • Final results of phase II trial of pegylated arginine deiminase (ADI-PEG20) in metastatic melanoma (MM) [abstract]
    • Feun LG, You M, Wu C, et al. Final results of phase II trial of pegylated arginine deiminase (ADI-PEG20) in metastatic melanoma (MM) [abstract]. J Clin Oncol. 2010;28(Suppl 15):8528.
    • (2010) J Clin Oncol , vol.28 , Issue.SUPPL. 15 , pp. 8528
    • Feun, L.G.1    You, M.2    Wu, C.3
  • 31
    • 73149106998 scopus 로고    scopus 로고
    • Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4
    • Tsai WB, Aiba I, Lee SY, Feun L, Savaraj N, Kuo MT. Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4. Mol Cancer Ther. 2009;8(12):3223-3233.
    • (2009) Mol Cancer Ther , vol.8 , Issue.12 , pp. 3223-3233
    • Tsai, W.B.1    Aiba, I.2    Lee, S.Y.3    Feun, L.4    Savaraj, N.5    Kuo, M.T.6
  • 32
    • 45549107064 scopus 로고    scopus 로고
    • Arginine deprivation as a targeted therapy for cancer
    • Feun L, You M, Wu CJ, et al. Arginine deprivation as a targeted therapy for cancer. Curr Pharm Des. 2008;14(11):1049-1057.
    • (2008) Curr Pharm Des , vol.14 , Issue.11 , pp. 1049-1057
    • Feun, L.1    You, M.2    Wu, C.J.3
  • 33
    • 84871864547 scopus 로고    scopus 로고
    • Enhancing arginine deprivation therapy in melanoma by combining with cisplatin
    • Paper presented at, April 17-21, Washington, DC
    • You M, Savaraj N, Wu CJ, et al. Enhancing arginine deprivation therapy in melanoma by combining with cisplatin. Paper presented at: 101st Annual Meeting of the American Association of Cancer Research; April 17-21, 2010; Washington, DC.
    • (2010) 101st Annual Meeting of the American Association of Cancer Research
    • You, M.1    Savaraj, N.2    Wu, C.J.3
  • 34
    • 77950501356 scopus 로고    scopus 로고
    • The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines
    • You M, Savaraj N, Wangpaichitr M, et al. The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines. Biochem Biophys Res Commun. 2010;394(3):760-766.
    • (2010) Biochem Biophys Res Commun , vol.394 , Issue.3 , pp. 760-766
    • You, M.1    Savaraj, N.2    Wangpaichitr, M.3
  • 35
    • 85027955688 scopus 로고    scopus 로고
    • Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells
    • Vynnytska BO, Mayevska OM, Kurlishchuk YV, Bobak YP, Stasyk OV. Canavanine augments proapoptotic effects of arginine deprivation in cultured human cancer cells. Anticancer Drugs. 2011;22(2):148-157.
    • (2011) Anticancer Drugs , vol.22 , Issue.2 , pp. 148-157
    • Vynnytska, B.O.1    Mayevska, O.M.2    Kurlishchuk, Y.V.3    Bobak, Y.P.4    Stasyk, O.V.5
  • 36
    • 84857502470 scopus 로고    scopus 로고
    • Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation
    • Vynnytska-Myronovska B, Bobak Y, Garbe Y, Dittfeld C, Stasyk OV, Kunz-Schughart LA. Single amino acid arginine starvation efficiently sensitizes cancer cells to canavanine treatment and irradiation. Int J Cancer. 2012;130(9):2164-2175.
    • (2012) Int J Cancer , vol.130 , Issue.9 , pp. 2164-2175
    • Vynnytska-Myronovska, B.1    Bobak, Y.2    Garbe, Y.3    Dittfeld, C.4    Stasyk, O.V.5    Kunz-Schughart, L.A.6
  • 37
    • 33845761445 scopus 로고    scopus 로고
    • In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion
    • Szlosarek PW, Klabatsa A, Pallaska A, et al. In vivo loss of expression of argininosuccinate synthetase in malignant pleural mesothelioma is a biomarker for susceptibility to arginine depletion. Clin Cancer Res. 2006;12(23):7126-7131.
    • (2006) Clin Cancer Res , vol.12 , Issue.23 , pp. 7126-7131
    • Szlosarek, P.W.1    Klabatsa, A.2    Pallaska, A.3
  • 38
    • 33846625891 scopus 로고    scopus 로고
    • Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase
    • Yoon CY, Shim YJ, Kim EH, et al. Renal cell carcinoma does not express argininosuccinate synthetase and is highly sensitive to arginine deprivation via arginine deiminase. Int J Cancer. 2007;120(4):897-905.
    • (2007) Int J Cancer , vol.120 , Issue.4 , pp. 897-905
    • Yoon, C.Y.1    Shim, Y.J.2    Kim, E.H.3
  • 39
    • 58349098150 scopus 로고    scopus 로고
    • Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis
    • Kim RH, Coates JM, Bowles TL, et al. Arginine deiminase as a novel therapy for prostate cancer induces autophagy and caspase-independent apoptosis. Cancer Res. 2009;69(2):700-708.
    • (2009) Cancer Res , vol.69 , Issue.2 , pp. 700-708
    • Kim, R.H.1    Coates, J.M.2    Bowles, T.L.3
  • 40
    • 6344291935 scopus 로고    scopus 로고
    • Arginine deiminase enhances dexamethasone-induced cytotoxicity in human T-lymphoblastic leukemia CCRF-CEM cells
    • Noh EJ, Kang SW, Shin YJ, et al. Arginine deiminase enhances dexamethasone-induced cytotoxicity in human T-lymphoblastic leukemia CCRF-CEM cells. Int J Cancer. 2004;112(3):502-508.
    • (2004) Int J Cancer , vol.112 , Issue.3 , pp. 502-508
    • Noh, E.J.1    Kang, S.W.2    Shin, Y.J.3
  • 41
    • 77949735952 scopus 로고    scopus 로고
    • Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma
    • Kobayashi E, Masuda M, Nakayama R, et al. Reduced argininosuccinate synthetase is a predictive biomarker for the development of pulmonary metastasis in patients with osteosarcoma. Mol Cancer Ther. 2010;9(3):535-544.
    • (2010) Mol Cancer Ther , vol.9 , Issue.3 , pp. 535-544
    • Kobayashi, E.1    Masuda, M.2    Nakayama, R.3
  • 43
    • 3042744030 scopus 로고    scopus 로고
    • Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: Results from phase I/II studies
    • Izzo F, Marra P, Beneduce G, et al. Pegylated arginine deiminase treatment of patients with unresectable hepatocellular carcinoma: results from phase I/II studies. J Clin Oncol. 2004;22(10):1815-1822.
    • (2004) J Clin Oncol , vol.22 , Issue.10 , pp. 1815-1822
    • Izzo, F.1    Marra, P.2    Beneduce, G.3
  • 44
    • 32944469353 scopus 로고    scopus 로고
    • Pegylated arginine deiminase treatment of patients with metastatic melanoma: Results from phase I and II studies
    • Ascierto PA, Scala S, Castello G, et al. Pegylated arginine deiminase treatment of patients with metastatic melanoma: results from phase I and II studies. J Clin Oncol. 2005;23(30):7660-7668.
    • (2005) J Clin Oncol , vol.23 , Issue.30 , pp. 7660-7668
    • Ascierto, P.A.1    Scala, S.2    Castello, G.3
  • 45
    • 0031900542 scopus 로고    scopus 로고
    • Role of nitric oxide in tumour progression: Lessons from human tumours
    • Thomsen LL, Miles DW. Role of nitric oxide in tumour progression: lessons from human tumours. Cancer Metastasis Rev. 1998;17(1):107-118.
    • (1998) Cancer Metastasis Rev , vol.17 , Issue.1 , pp. 107-118
    • Thomsen, L.L.1    Miles, D.W.2
  • 46
    • 0036883907 scopus 로고    scopus 로고
    • Blocking NO synthesis: How, where and why?
    • Vallance P, Leiper J. Blocking NO synthesis: how, where and why? Nat Rev Drug Discov. 2002;1(12):939-950.
    • (2002) Nat Rev Drug Discov , vol.1 , Issue.12 , pp. 939-950
    • Vallance, P.1    Leiper, J.2
  • 47
    • 1242341462 scopus 로고    scopus 로고
    • NO and angiogenesis
    • Cooke JP. NO and angiogenesis. Atheroscler Suppl. 2003;4(4):53-60.
    • (2003) Atheroscler Suppl , vol.4 , Issue.4 , pp. 53-60
    • Cooke, J.P.1
  • 48
    • 77952316981 scopus 로고    scopus 로고
    • Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma
    • Glazer ES, Piccirillo M, Albino V, et al. Phase II study of pegylated arginine deiminase for nonresectable and metastatic hepatocellular carcinoma. J Clin Oncol. 2010;28(13):2220-2226.
    • (2010) J Clin Oncol , vol.28 , Issue.13 , pp. 2220-2226
    • Glazer, E.S.1    Piccirillo, M.2    Albino, V.3
  • 49
    • 77957245576 scopus 로고    scopus 로고
    • A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients
    • Yang TS, Lu SN, Chao Y, et al. A randomised phase II study of pegylated arginine deiminase (ADI-PEG 20) in Asian advanced hepatocellular carcinoma patients. Br J Cancer. 2010;103(7):954-960.
    • (2010) Br J Cancer , vol.103 , Issue.7 , pp. 954-960
    • Yang, T.S.1    Lu, S.N.2    Chao, Y.3
  • 50
    • 82555182013 scopus 로고    scopus 로고
    • A phase I study of recombinant human arginase I (rhArgI) for patients with advanced hepatocellular carcinoma [abstract]
    • Yau CC, Chan P, Pang R, et al. A phase I study of recombinant human arginase I (rhArgI) for patients with advanced hepatocellular carcinoma [abstract]. J Clin Oncol. 2010;28:e13503.
    • (2010) J Clin Oncol , vol.28
    • Yau, C.C.1    Chan, P.2    Pang, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.