Short communication: HIV+ viremic slow progressors maintain low regulatory t cell numbers in rectal mucosa but exhibit high t cell activation

AIDS Research and Human Retroviruses

Volumn 29, Issue 1, 2013, Pages 172-177

  Shaw, Julia M ^a   Hunt, Peter W ^b   Critchfield, J William ^a   McConnell, Delandy H ^a   Garcia, Juan Carlos ^a   Pollard, Richard B ^a   Somsouk, Ma ^c   Deeks, Steven G ^b   Shacklett, Barbara L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CD3+ T LYMPHOCYTE; CD4+ CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL PROLIFERATION; CERCOCEBUS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE COURSE; FLOW CYTOMETRY; GASTROINTESTINAL MUCOSA; HAPLORHINI; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTED PATIENT; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNITY; PHENOTYPE; PREDICTION; PRIORITY JOURNAL; RECTUM MUCOSA; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; VIREMIC SLOW PROGRESSOR;

DISEASE PROGRESSION; HIV INFECTIONS; HUMANS; INTESTINAL MUCOSA; LYMPHOCYTE ACTIVATION; LYMPHOCYTE COUNT; RECTUM; T-LYMPHOCYTES, REGULATORY; VIRAL LOAD; VIREMIA;

EID: 84871881594     PISSN: 08892229     EISSN: 19318405     Source Type: Journal    
DOI: 10.1089/aid.2012.0268     Document Type: Article

References (34)

1. Mellors JW, Munoz A, Giorgi JV, et al.: Plasma viral load and CD4+ lymphocytes as prognostic markers of HIV-1 infection. Ann Intern Med 1997;126(12):946-954.
2. Rodriguez B, Sethi AK, Cheruvu VK, et al.: Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection. JAMA 2006;296(12):1498-1506.
3. Hsue PY, Hunt PW, Schnell A, et al.: Role of viral replication, antiretroviral therapy, and immunodeficiency in HIVassociated atherosclerosis. AIDS 2009;23(9):1059-1067.
4. Choudhary SK, Vrisekoop N, Jansen CA, et al.: Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease. J Virol 2007;81(16):8838-8842.
5. Rotger M, Dalmau J, Rauch A, et al.: Comparative transcriptomics of extreme phenotypes of human HIV-1 infection and SIV infection in sooty mangabey and rhesus macaque. J Clin Invest 2011;121(6):2391-2400.
6. Liovat AS, Jacquelin B, Ploquin MJ, Barre-Sinoussi F, and Muller-Trutwin MC: African non human primates infected by SIV - why don't they get sick? Lessons from studies on the early phase of non-pathogenic SIV infection. Curr HIV Res 2009;7(1):39-50.
7. Brenchley JM, Silvestri G, and Douek DC: Nonprogressive and progressive primate immunodeficiency lentivirus infections. Immunity 2010;32(6):737-742.
8. Deeks SG, Kitchen CMR, Liu L, et al.: Immune activation set point during early HIV infection predicts subsequent CD4 + T-cell changes independent of viral load. Blood 2004;104(4): 942-947.
9. Giorgi JV, Hultin LE, McKeating JA, et al.: Shorter survival in advanced human immunodeficiency virus type 1 infection is more closely associated with T lymphocyte activation than with plasma virus burden or virus chemokine coreceptor usage. J Infect Dis 1999;179(4):859-870.
10. Liu Z, Cumberland WG, Hultin LE, Prince HE, Detels R, and Giorgi JV: Elevated CD38 antigen expression on CD8 + T cells is a stronger marker for the risk of chronic HIV disease progression to AIDS and death in the Multicenter AIDS Cohort Study than CD4+ cell count, soluble immune activation markers, or combinations of HLA-DR and CD38 expression. J Acquir Immune Defic Syndr 1997; 16(2):83-92.
11. Sousa AE, Carneiro J, Meier-Schellersheim M, Grossman Z, and Victorino RMM: CD4 T cell depletion is linked directly to immune activation in the pathogenesis of HIV-1 and HIV-2 but only indirectly to the viral load. J Immunol 2002;169(6): 3400-3406.
12. Brenchley JM, Schacker TW, Ruff LE, et al.: CD4+ T cell depletion during all stages of HIV disease occurs predominantly in the gastrointestinal tract. J Exp Med 2004;200(6): 749-759.
13. Mattapallil JJ, Douek DC, Hill B, Nishimura Y, Martin M, and Roederer M: Massive infection and loss of memory CD4 + T cells in multiple tissues during acute SIV infection. Nature 2005;434(7037):1093-1097.
14. Veazey RS, DeMaria M, Chalifoux LV, et al.: Gastrointestinal tract as a major site of CD4 + T cell depletion and viral replication in SIV infection. Science 1998;280(5362): 427-431.
15. Mehandru S, Poles MA, Tenner-Racz K, et al.: Primary HIV-1 infection is associated with preferential depletion of CD4 + T lymphocytes from effector sites in the gastrointestinal tract. J Exp Med 2004;200(6):761-770.
16. Brenchley JM and Douek DC: HIV infection and the gastrointestinal immune system. Mucosal Immunol 2007;1(1): 23-30.
17. Gordon SN, Klatt NR, Bosinger SE, et al.: Severe depletion of mucosal CD4 + T cells in AIDS-free simian immunodeficiency virus-infected sooty mangabeys. J Immunol 2007; 179(5):3026-3034.
18. Bosinger SE, Li Q, Gordon SN, et al.: Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J Clin Invest 2009;119(12): 3556-3572.
19. Jacquelin B, Mayau V, Targat B, et al.: Nonpathogenic SIV infection of African green monkeys induces a strong but rapidly controlled type I IFN response. J Clin Invest 2009; 119(12):3544-3555.
20. Belkaid Y and Rouse BT: Natural regulatory T cells in infectious disease. Nat Immunol 2005;6(4):353-360.
21. Fazekas de St Groth B and Landay AL: Regulatory T cells in HIV infection: Pathogenic or protective participants in the immune response? AIDS 2008;22(6):671-683.
22. Favre D, Lederer S, Kanwar B, et al.: Critical loss of the balance between Th17 and T regulatory cell populations in pathogenic SIV infection. PLoS Pathog 2009;5(2): e1000295.
23. Epple H-J, Loddenkemper C, Kunkel D, et al.: Mucosal but not peripheral FOXP3 + regulatory T cells are highly increased in untreated HIV infection and normalize after suppressive HAART. Blood 2006 2006;108(9):3072-3078.
24. Manches O and Bhardwaj N: Resolution of immune activation defines nonpathogenic SIV infection. J Clin Invest 2009;119(12):3512-3515.
25. Shaw JM, Hunt PW, Critchfield JW, et al.: Increased frequency of regulatory T cells accompanies increased immune activation in rectal mucosae of HIV-positive noncontrollers. J Virol 2011;85(21):11422-11434.
26. Ferre AL, Hunt PW, McConnell DH, et al.: HIV controllers with HLA-DRB1, 13 and HLA-DQB1, 06 alleles have strong, polyfunctional mucosal CD4 + T-cell responses. J Virol 2010;84(21):11020-11029.
27. Kiazyk SAK and Fowke KR: Loss of CD127 expression links immune activation and CD4 + T cell loss in HIV infection. Trends Microbiol 2008;16(12):567-573.
28. Paiardini M, Cervasi B, Albrecht H, et al.: Loss of CD127 expression defines an expansion of effector CD8 + T cells in HIV-infected individuals. J Immunol 2005;174(5): 2900-2909.
29. Vollbrecht T, Brackmann H, Henrich N, et al.: Impact of changes in antigen level on CD38/PD-1 co-expression on HIV-specific CD8 T cells in chronic, untreated HIV-1 infection. J Med Virol 2010;82(3):358-370.
30. Sumpter B, Dunham R, Gordon S, et al.: Correlates of preserved CD4 (+) T cell homeostasis during natural, nonpathogenic simian immunodeficiency virus infection of sooty mangabeys: Implications for AIDS pathogenesis. J Immunol 2007;178(3):1680-1691.
31. Hunt PW, Landay AL, Sinclair E, et al.: A low T regulatory cell response may contribute to both viral control and generalized immune activation in HIV controllers. PLoS One 2011;6(1):e15924.
32. Favre D, Mold J, Hunt PW, et al.: Tryptophan catabolism by indoleamine 2,3-dioxygenase 1 alters the balance of TH17 to regulatory T cells in HIV disease. Sci Transl Med 2010; 2(32):32-36.
33. Dunham R, Pagliardini P, Gordon S, et al.: The AIDS resistance of naturally SIV-infected sooty mangabeys is independent of cellular immunity to the virus. Blood 2006; 108(1):209-217.
34. Chan ML, Petravic J, Ortiz AM, et al.: Limited CD4 + T cell proliferation leads to preservation of CD4 + T cell counts in SIV-infected sooty mangabeys. Proc Biol Sci 2010;277(1701): 3773-3781