Obstructive sleep apnea is associated with increased chemoreflex sensitivity in patients with metabolic syndrome

Sleep

Volumn 36, Issue 1, 2013, Pages 41-49

  Trombetta, Ivani C ^a   Maki Nunes, Cristiane ^a   Toschi Dias, Edgar ^a   Alves, Maria Janieire N N ^a   Rondon, Maria Urbana P B ^a   Cepeda, Felipe X ^a   Drager, Luciano F ^a   Braga, Ana Maria F W ^a   Lorenzi Filho, Geraldo ^a   Negrao, Carlos E ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Autonomic control; Cardiovascular risk factors; Sleep disordered breathing; Sympathetic activation

Indexed keywords

CARBON DIOXIDE; NITROGEN; OXYGEN;

ADULT; APNEA HYPOPNEA INDEX; ARTICLE; CHEMORECEPTOR REFLEX; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; MALE; METABOLIC SYNDROME X; MICRONEUROGRAPHY; MUSCLE SYMPATHETIC NERVE ACTIVITY; POLYSOMNOGRAPHY; PRIORITY JOURNAL; PROSPECTIVE STUDY; SLEEP DISORDERED BREATHING;

ADULT; ANALYSIS OF VARIANCE; ANOXIA; CARBON DIOXIDE; CHEMORECEPTOR CELLS; FEMALE; HUMANS; HYPERCAPNIA; MALE; METABOLIC SYNDROME X; MIDDLE AGED; NITROGEN; OXYGEN; POLYSOMNOGRAPHY; PROSPECTIVE STUDIES; PULMONARY VENTILATION; REFLEX; SLEEP APNEA, OBSTRUCTIVE; SYMPATHETIC NERVOUS SYSTEM;

EID: 84871879448     PISSN: 01618105     EISSN: 15509109     Source Type: Journal    
DOI: 10.5665/sleep.2298     Document Type: Article

References (25)

1. Vgontzas AN, Bixler EO, Chrousos GP. Sleep apnea is a manifestation of the metabolic syndrome. Sleep Med Rev 2005;9:211-24. (Pubitemid 40694188)
2. Drager LF, Lopes HF, Maki-Nunes C, et al. The impact of obstructive sleep apnea on metabolic and inflammatory markers in consecutive patients with metabolic syndrome. PLoS One 2010;5:e12065.
3. Trombetta IC, Somers VK, Maki-Nunes C, et al. Consequences of comorbid sleep apnea in the metabolic syndrome - implications for cardiovascular risk. Sleep 2010;3:1193-9.
4. Grassi G, Dell'Oro R, Quarti-Trevano F, et al. Neuroadrenergic and reflex abnormalities in patients with metabolic syndrome. Diabetologia 2005;48:1359-65. (Pubitemid 41186102)
5. Narkiewicz K, Pesek CA, Kato M, Phillips BG, Davison DE, Somers VK. Baroreflex control of sympathetic nerve activity and heart rate in obstructive sleep apnea. Hypertension 1998;32:1039-43. (Pubitemid 29001433)
6. Grassi G, Seravalle G, Quarti-Trevano F, et al. Reinforcement of the adrenergic overdrive in the metabolic syndrome complicated by obstructive sleep apnea. J Hypertens 2010;28:1313-20.
7. Bradley TD, Floras JS. Sleep apnea and heart failure Part I: Obstructive sleep apnea. Circulation 2003;107:1671-8. (Pubitemid 36397338)
8. Somers VK, Dyken ME, Clary MP, Abboud FM. Sympathetic neural mechanisms in obstructive sleep apnea. J Clin Invest 1995;96:1897-1904.
9. Xie A, Skatrud JB, Puleo DS, Morgan BJ. Exposure to hypoxia produces long-lasting sympathetic activation in humans. J Appl Physiol 2001;91:1555-62. (Pubitemid 32900346)
10. Barretto AC, Santos AC, Munhoz R, et al. Increased muscle sympathetic nerve activity predicts mortality in heart failure patients. Int J Cardiol 2009;135:302-7.
11. St Croix CM, Satoh M, Morgan BJ, Skatrud JB, Dempsey JA. Role of respiratory motor output in within-breath modulation of muscle sympathetic nerve activity in humans. Circ Res 1999;85:457-69. (Pubitemid 29409622)
12. Grundy SM, Cleeman JI, Daniels SR, et al. American Heart Association; National Heart, Lung, and Blood Institute. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 2005;112:2735-52. (Pubitemid 41532612)
13. Somers VK, Mark AL, Zavala DC, Abboud FM. Contrasting effects of hypoxia and hyperoxic hypercapnia on ventilation and sympathetic activity in humans. J Appl Physiol 1989;67:2101-6. (Pubitemid 20039424)
14. Somers VK, Mark AL, Zavala DC, Abboud FM. Influence of ventilation and hypocapnia on sympathetic nerve responses to hypoxia in normal humans. J Appl Physiol 1989;67:2095-2100. (Pubitemid 20039423)
15. Drager LF, Bortolotto LA, Lorenzi MC, Figueiredo AC, Krieger EM, Lorenzi-Filho G. Early signs of atherosclerosis in obstructive sleep apnea. Am J Respir Crit Care Med 2005;172:613-8. (Pubitemid 41232973)
16. Drager LF, Bortolotto LA, Krieger EM, Lorenzi-Filho G. Additive effects of obstructive sleep apnea and hypertension on early markers of carotid atherosclerosis. Hypertension 2009;53:64-9.
17. American Academy of Sleep Medicine. The AASM manual for the scoring of sleep and associated events. Westchester, IL: American Academy of Sleep Medicine; 2007.
18. Fagius J, Wallin BG. Long-term variability and reproducibility of human muscle nerve activity at rest, as reassessed after a decade. Clin Auton Res 1993;3:201-5. (Pubitemid 23244976)
19. Tai MM. A mathematical model for the determination of total area under glucose tolerance and other metabolic curves. Diabetes Care 1994;17:152-4. (Pubitemid 24035313)
20. Kara T, Narkiewicz K, Somers VK. Chemoreflexes - physiology and clinical implications. Acta Physiol Scand 2003;177:377-84. (Pubitemid 36337641)
21. Narkiewicz K, Kato M, Pesek CA, Somers VK. Human obesity is characterized by a selective potentiation of central chemoreflex sensitivity. Hypertension 1999;33:1153-8. (Pubitemid 29230965)
22. Narkiewicz K, van de Borne PJ, Pesek CA, Dyken ME, Montano N, Somers VK. Selective potentiation of peripheral chemoreflex sensitivity in obstructive sleep apnea. Circulation 1999;99:1183-9. (Pubitemid 29120090)
23. Heistad DD, Abboud FM, Mark AL, Schmid PG. Interaction of baroreceptor and chemoreceptor reflexes. Modulation of the chemoreceptor reflex by changes in baroreceptor activity. J Clin Invest 1974;53:1226-36.
24. Somers VK, Mark AL, Abboud FM. Interaction of baroreceptor and chemoreceptor reflex control of sympathetic nerve activity in normal humans. J Clin Invest 1991;87:1953-7.
25. Loewen A, Ostrowski M, Laprairie J, et al. Determinants of ventilatory instability in obstructive sleep apnea: inherent or acquired? Sleep 2009;32:1355-65.