Retinal lesions and other potential confounders of ocular research in inbred mice

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 7, 2012, Pages 3764-3765

  Pritchett Corning, Kathleen R ^a   Clifford, Charles B ^a   Elder, Bruce J ^a   Vezina, Mark ^b  

^a Research Models and Services   (United States)

^b Preclinical Services   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 4; NERVE PROTEIN;

ANIMAL MODEL; APOPTOSIS; EYE DISEASE; GENE MUTATION; GENETIC ASSOCIATION; GENETIC MANIPULATION; GENETIC VARIABILITY; GLUCOSE METABOLISM; INFLAMMATION; LETTER; MEDICAL RESEARCH; MOUSE; NECROSIS; NONHUMAN; PRIORITY JOURNAL; PUBLICATION; RETINA DEGENERATION; RETINA DISEASE; SCHIZOPHRENIA; ANIMAL; C57BL MOUSE; EMBRYONIC STEM CELL; GENETICS; MUTATION; NOTE;

ANIMALS; EMBRYONIC STEM CELLS; MICE, INBRED C57BL; MUTATION; NERVE TISSUE PROTEINS; RETINAL DEGENERATION;

EID: 84871877088     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10056     Document Type: Letter

References (28)

1. Mattapallil MJ, Wawrousek EF, Chan CC, et al. The rd8 mutation of the Crb1 gene is present in vendor lines of C57BL/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes. Invest Ophthalmol Vis Sci. 2012;53:2921-2927.
2. Pettitt SJ, Liang Q, Rairdan XY, et al. Agouti C57BL/6N embryonic stem cells for mouse genetic resources. Nat Methods. 2009;6:493-495.
3. Skarnes WC, Rosen B, West AP, et al. A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011;474:337-342.
4. Mehalow AK, Kameya S, Smith RS, et al. CRB1 is essential for external limiting membrane integrity and photoreceptor morphogenesis in the mammalian retina. Hum Mol Genet. 2003;12:2179-2189.
5. Chang B, Hawes NL, Hurd RE, et al. Retinal degeneration mutants in the mouse. Vision Res. 2002;42:517-525.
6. Aleman TS, Cideciyan AV, Aguirre GK, et al. Human CRB1- associated retinal degeneration: comparison with the rd8 Crb1-mutant mouse model. Invest Ophthalmol Vis Sci. 2011; 52:6898-6910.
7. Specht CG, Schoepfer R. Deletion of the alpha-synuclein locus in a subpopulation of C57BL/6J inbred mice. BMC Neurosci. 2001;2:11.
8. Freeman HC, Hugill A, Dear NT, Ashcroft FM, Cox RD. Deletion of nicotinamide nucleotide transhydrogenase: a new quantitive trait locus accounting for glucose intolerance in C57BL/6J mice. Diabetes. 2006;55:2153-2156.
9. Smith RS, Sundberg JP. Inbred C57 black mice: microphthalmia and ocular infections. JAX NOTES. 1995;463.
10. Smith RS, Roderick TH, Sundberg JP. Microphthalmia and associated abnormalities in inbred black mice. Lab Anim Sci. 1994;44:551-560.
11. Pierro LJ, Spiggle J. Congenital eye defects in the mouse. I. Corneal opacity in C57 black mice. J Exp Zool. 1967;166:25-33.
12. Bourdi M, Davies JS, Pohl LR. Mispairing C57BL/6 substrains of genetically engineered mice and wild-type controls can lead to confounding results as it did in studies of JNK2 in acetaminophen and concanavalin A liver injury. Chem Res Toxicol. 2011;24:794-796.
13. Kenneth NS, Younger JM, Hughes ED, et al. An inactivating caspase 11 passenger mutation originating from the 129 murine strain in mice targeted for c-IAP1. Biochem J. 2012; 443:355-359.
14. Kayagaki N, Warming S, Lamkanfi M, et al. Non-canonical inflammasome activation targets caspase-11. Nature. 2011; 479:117-121.
15. Clapcote SJ, Roder JC. Deletion polymorphism of Disc1 is common to all 129 mouse substrains: implications for genetargeting studies of brain function. Genetics. 2006;173:2407-2410.
16. Boross P, Arandhara VL, Martin-Ramirez J, et al. The inhibiting Fc receptor for IgG, FcgammaRIIB, is a modifier of autoimmune susceptibility. J Immunol. 2011;187:1304-1313.
17. Dumont F, Barrois R. Electrokinetic properties of splenic lymphocytes from the low-lipopolysaccharide responder C3H/ HeJ mice. Folia Biol (Praha). 1976;12:145-150.
18. Poltorak A, He X, Smirnova I, et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science. 1998;282:2085-2088.
19. Meng H, Vera I, Che N, et al. Identification of Abcc6 as the major causal gene for dystrophic cardiac calcification in mice through integrative genomics. Proc Natl Acad Sci U S A. 2007; 104:4530-4535.
20. Johnson KR, Zheng QY, Erway LC. A major gene affecting agerelated hearing loss is common to at least ten inbred strains of mice. Genomics. 2000;70:171-180.
21. Sellers RS, Clifford CB, Treuting PM, Brayton C. Immunological variation between inbred laboratory mouse strains: points to consider in phenotyping genetically immunomodified mice. Vet Pathol. 2012;49:32-43.
22. Treuting PM, Clifford CB, Sellers RS, Brayton CF. Of mice and microflora: considerations for genetically engineered mice. Vet Pathol. 2012;49:44-63.
23. Sellers RS. The gene or not the gene-that is the question: understanding the genetically engineered mouse phenotype. Vet Pathol. 2012;49:5-15.
24. Cvekl A, Mitton KP. Epigenetic regulatory mechanisms in vertebrate eye development and disease. Heredity (Edinb). 2010;105:135-151.
25. Cardiff RD, Ward JM, Barthold SW. 'One medicine-one pathology': are veterinary and human pathology prepared? Lab Invest. 2008;88:18-26.
26. Brayton C. Spontaneous diseases in commonly used mouse strains/stocks. Available at: http://www. hopkinsmedicine.org/mcp/PHENOCORE/CoursePDFs/ 09s1BraytonMouseDzOutline75p.pdf. Accessed April 12, 2012.
27. Festing MFW. Inbred strains of mice and their characteristics. Available at: http://www.informatics.jax.org/external/festing/ search_form.cgi. Accessed April 12, 2012.
28. Stevens JC, Banks GT, Festing MF, Fisher EM. Quiet mutations in inbred strains of mice. Trends Mol Med. 2007;13:512-519.