-
1
-
-
0037464588
-
A vision for the future of genomics research
-
10.1038/nature01626, 12695777
-
Collins FS, Green ED, Guttmacher AE, Guyer MS. A vision for the future of genomics research. Nature 2003, 422(6934):835-847. 10.1038/nature01626, 12695777.
-
(2003)
Nature
, vol.422
, Issue.6934
, pp. 835-847
-
-
Collins, F.S.1
Green, E.D.2
Guttmacher, A.E.3
Guyer, M.S.4
-
2
-
-
41149120561
-
A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions
-
10.1016/j.ajhg.2007.12.020, 2427295, 18319070
-
Janssens AC, Gwinn M, Bradley LA, Oostra BA, van Duijn CM, Khoury MJ. A critical appraisal of the scientific basis of commercial genomic profiles used to assess health risks and personalize health interventions. Am J Hum Genet 2008, 82(3):593-599. 10.1016/j.ajhg.2007.12.020, 2427295, 18319070.
-
(2008)
Am J Hum Genet
, vol.82
, Issue.3
, pp. 593-599
-
-
Janssens, A.C.1
Gwinn, M.2
Bradley, L.A.3
Oostra, B.A.4
van Duijn, C.M.5
Khoury, M.J.6
-
3
-
-
70349956433
-
Finding the missing heritability of complex diseases
-
10.1038/nature08494, 2831613, 19812666
-
Manolio TA, Collins FS, Cox NJ, Goldstein DB, Hindorff LA, Hunter DJ, McCarthy MI, Ramos EM, Cardon LR, Chakravarti A, Cho JH, Guttmacher AE, Kong A, Kruglyak L, Mardis E, Rotimi CN, Slatkin M, Valle D, Whittemore AS, Boehnke M, Clark AG, Eichler EE, Gibson G, Haines JL, Mackay TF, McCarroll SA, Visscher PM. Finding the missing heritability of complex diseases. Nature 2009, 461(7265):747-753. 10.1038/nature08494, 2831613, 19812666.
-
(2009)
Nature
, vol.461
, Issue.7265
, pp. 747-753
-
-
Manolio, T.A.1
Collins, F.S.2
Cox, N.J.3
Goldstein, D.B.4
Hindorff, L.A.5
Hunter, D.J.6
McCarthy, M.I.7
Ramos, E.M.8
Cardon, L.R.9
Chakravarti, A.10
Cho, J.H.11
Guttmacher, A.E.12
Kong, A.13
Kruglyak, L.14
Mardis, E.15
Rotimi, C.N.16
Slatkin, M.17
Valle, D.18
Whittemore, A.S.19
Boehnke, M.20
Clark, A.G.21
Eichler, E.E.22
Gibson, G.23
Haines, J.L.24
Mackay, T.F.25
McCarroll, S.A.26
Visscher, P.M.27
more..
-
4
-
-
65949099120
-
Genetic Risk Prediction - Are We There Yet?
-
10.1056/NEJMp0810107, 19369656
-
Kraft P, Hunter D. Genetic Risk Prediction - Are We There Yet?. N Engl J Med 2009, 360(17):1701-1703. 10.1056/NEJMp0810107, 19369656.
-
(2009)
N Engl J Med
, vol.360
, Issue.17
, pp. 1701-1703
-
-
Kraft, P.1
Hunter, D.2
-
5
-
-
65949107547
-
Common genetic variation and human traits
-
10.1056/NEJMp0806284, 19369660
-
Goldstein DB. Common genetic variation and human traits. N Engl J Med 2009, 360(17):1696-1698. 10.1056/NEJMp0806284, 19369660.
-
(2009)
N Engl J Med
, vol.360
, Issue.17
, pp. 1696-1698
-
-
Goldstein, D.B.1
-
6
-
-
77954140531
-
Common SNPs explain a large proportion of the heritability for human height
-
10.1038/ng.608, 3232052, 20562875
-
Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR, Madden PA, Heath AC, Martin NG, Montgomery GW, Goddard ME, Visscher PM. Common SNPs explain a large proportion of the heritability for human height. Nat Genet 2010, 42(7):565-569. 10.1038/ng.608, 3232052, 20562875.
-
(2010)
Nat Genet
, vol.42
, Issue.7
, pp. 565-569
-
-
Yang, J.1
Benyamin, B.2
McEvoy, B.P.3
Gordon, S.4
Henders, A.K.5
Nyholt, D.R.6
Madden, P.A.7
Heath, A.C.8
Martin, N.G.9
Montgomery, G.W.10
Goddard, M.E.11
Visscher, P.M.12
-
8
-
-
40849097776
-
Heritability in the genomics era-concepts and misconceptions
-
Visscher PM, Hill WG, Wray NR. Heritability in the genomics era-concepts and misconceptions. Nat Rev Genet 2008, 9(4):255-266.
-
(2008)
Nat Rev Genet
, vol.9
, Issue.4
, pp. 255-266
-
-
Visscher, P.M.1
Hill, W.G.2
Wray, N.R.3
-
9
-
-
0001118328
-
Heritability of Threshold Characters
-
1209482, 17247344
-
Dempster ER, Lerner IM. Heritability of Threshold Characters. Genetics 1950, 35(2):212-236. 1209482, 17247344.
-
(1950)
Genetics
, vol.35
, Issue.2
, pp. 212-236
-
-
Dempster, E.R.1
Lerner, I.M.2
-
10
-
-
33747881836
-
Predictive testing for complex diseases using multiple genes: fact or fiction?
-
10.1097/01.gim.0000229689.18263.f4, 16845271
-
Janssens AC, Aulchenko YS, Elefante S, Borsboom GJ, Steyerberg EW, van Duijn CM. Predictive testing for complex diseases using multiple genes: fact or fiction?. Genet Med 2006, 8(7):395-400. 10.1097/01.gim.0000229689.18263.f4, 16845271.
-
(2006)
Genet Med
, vol.8
, Issue.7
, pp. 395-400
-
-
Janssens, A.C.1
Aulchenko, Y.S.2
Elefante, S.3
Borsboom, G.J.4
Steyerberg, E.W.5
van Duijn, C.M.6
-
11
-
-
77949653596
-
Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases
-
10.1038/ejhg.2009.209, 2987256, 19935832
-
Moonesinghe R, Liu T, Khoury MJ. Evaluation of the discriminative accuracy of genomic profiling in the prediction of common complex diseases. Eur J Hum Genet 2010, 18(4):485-489. 10.1038/ejhg.2009.209, 2987256, 19935832.
-
(2010)
Eur J Hum Genet
, vol.18
, Issue.4
, pp. 485-489
-
-
Moonesinghe, R.1
Liu, T.2
Khoury, M.J.3
-
12
-
-
77649209124
-
The genetic interpretation of area under the ROC curve in genomic profiling
-
10.1371/journal.pgen.1000864, 2829056, 20195508
-
Wray NR, Yang J, Goddard ME, Visscher PM. The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet 2010, 6(2):e1000864. 10.1371/journal.pgen.1000864, 2829056, 20195508.
-
(2010)
PLoS Genet
, vol.6
, Issue.2
-
-
Wray, N.R.1
Yang, J.2
Goddard, M.E.3
Visscher, P.M.4
-
13
-
-
78650687187
-
A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained
-
10.1371/journal.pgen.1001230, 2996330, 21151957
-
So HC, Sham PC. A unifying framework for evaluating the predictive power of genetic variants based on the level of heritability explained. PLoS Genet 2010, 6(12):e1001230. 10.1371/journal.pgen.1001230, 2996330, 21151957.
-
(2010)
PLoS Genet
, vol.6
, Issue.12
-
-
So, H.C.1
Sham, P.C.2
-
15
-
-
0035799806
-
Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance
-
10.1056/NEJM200105033441801, 11333990
-
Tuomilehto J, Lindström J, Eriksson JG, Valle TT, Hämäläinen H, Ilanne-Parikka P, Keinänen-Kiukaanniemi S, Laakso M, Louheranta A, Rastas M, Salminen V, Uusitupa M. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 2001, 344(18):1343-1350. 10.1056/NEJM200105033441801, 11333990.
-
(2001)
N Engl J Med
, vol.344
, Issue.18
, pp. 1343-1350
-
-
Tuomilehto, J.1
Lindström, J.2
Eriksson, J.G.3
Valle, T.T.4
Hämäläinen, H.5
Ilanne-Parikka, P.6
Keinänen-Kiukaanniemi, S.7
Laakso, M.8
Louheranta, A.9
Rastas, M.10
Salminen, V.11
Uusitupa, M.12
-
16
-
-
57649243614
-
Genome-based prediction of common diseases: advances and prospects
-
10.1093/hmg/ddn250, 18852206
-
Janssens AC, van Duijn CM. Genome-based prediction of common diseases: advances and prospects. Hum Mol Genet 2008, 17(R2):R166-173. 10.1093/hmg/ddn250, 18852206.
-
(2008)
Hum Mol Genet
, vol.17
, Issue.R2
-
-
Janssens, A.C.1
van Duijn, C.M.2
-
17
-
-
76249109928
-
Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study
-
10.1136/bmj.b4838, 2806945, 20075150
-
Talmud PJ, Hingorani AD, Cooper JA, Marmot MG, Brunner EJ, Kumari M, Kivimaki M, Humphries SE. Utility of genetic and non-genetic risk factors in prediction of type 2 diabetes: Whitehall II prospective cohort study. BMJ 2010, 340:b4838. 10.1136/bmj.b4838, 2806945, 20075150.
-
(2010)
BMJ
, vol.340
-
-
Talmud, P.J.1
Hingorani, A.D.2
Cooper, J.A.3
Marmot, M.G.4
Brunner, E.J.5
Kumari, M.6
Kivimaki, M.7
Humphries, S.E.8
-
18
-
-
0032953097
-
Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study
-
10.1007/s001250051131, 10064092
-
Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study. Diabetologia 1999, 42(2):139-145. 10.1007/s001250051131, 10064092.
-
(1999)
Diabetologia
, vol.42
, Issue.2
, pp. 139-145
-
-
Poulsen, P.1
Kyvik, K.O.2
Vaag, A.3
Beck-Nielsen, H.4
-
19
-
-
0034927358
-
The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches
-
Risch N. The genetic epidemiology of cancer: interpreting family and twin studies and their implications for molecular genetic approaches. Cancer Epidemiol Biomarkers Prev 2001, 10(7):733-741.
-
(2001)
Cancer Epidemiol Biomarkers Prev
, vol.10
, Issue.7
, pp. 733-741
-
-
Risch, N.1
-
20
-
-
0030790332
-
Familial determinants of moderate and intense physical activity: a twin study
-
10.1097/00005768-199708000-00012, 9268964
-
Lauderdale DS, Fabsitz R, Meyer JM, Sholinsky P, Ramakrishnan V, Goldberg J. Familial determinants of moderate and intense physical activity: a twin study. Med Sci Sports Exerc 1997, 29(8):1062-1068. 10.1097/00005768-199708000-00012, 9268964.
-
(1997)
Med Sci Sports Exerc
, vol.29
, Issue.8
, pp. 1062-1068
-
-
Lauderdale, D.S.1
Fabsitz, R.2
Meyer, J.M.3
Sholinsky, P.4
Ramakrishnan, V.5
Goldberg, J.6
-
21
-
-
84860587659
-
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
-
10.2337/db11-0973, 22415877
-
Scott RA, Chu AY, Grarup N, Manning AK, Hivert MF, Shungin D, Tonjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, Rasmussen-Torvik LJ, Stringham HM, Tanaka T, Aadahl M, Arking DE, Bergmann S, Boerwinkle E, Bonnycastle LL, Bornstein SR, Brunner E, Bumpstead SJ, Brage S, Carlson OD, Chen H, Chen YD, et al. No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels. Diabetes 2012, 61(5):1291-1296. 10.2337/db11-0973, 22415877.
-
(2012)
Diabetes
, vol.61
, Issue.5
, pp. 1291-1296
-
-
Scott, R.A.1
Chu, A.Y.2
Grarup, N.3
Manning, A.K.4
Hivert, M.F.5
Shungin, D.6
Tonjes, A.7
Yesupriya, A.8
Barnes, D.9
Bouatia-Naji, N.10
Glazer, N.L.11
Jackson, A.U.12
Kutalik, Z.13
Lagou, V.14
Marek, D.15
Rasmussen-Torvik, L.J.16
Stringham, H.M.17
Tanaka, T.18
Aadahl, M.19
Arking, D.E.20
Bergmann, S.21
Boerwinkle, E.22
Bonnycastle, L.L.23
Bornstein, S.R.24
Brunner, E.25
Bumpstead, S.J.26
Brage, S.27
Carlson, O.D.28
Chen, H.29
Chen, Y.D.30
more..
-
22
-
-
1542314297
-
Revisiting the clinical validity of multiplex genetic testing in complex diseases
-
author reply 588-589, 10.1086/382052, 1182273, 14973786
-
Janssens AC, Pardo MC, Steyerberg EW, van Duijn CM. Revisiting the clinical validity of multiplex genetic testing in complex diseases. Am J Hum Genet 2004, 74(3):585-588. author reply 588-589, 10.1086/382052, 1182273, 14973786.
-
(2004)
Am J Hum Genet
, vol.74
, Issue.3
, pp. 585-588
-
-
Janssens, A.C.1
Pardo, M.C.2
Steyerberg, E.W.3
van Duijn, C.M.4
-
23
-
-
0141991939
-
Lifetime risk for diabetes mellitus in the United States
-
10.1001/jama.290.14.1884, 14532317
-
Narayan KM, Boyle JP, Thompson TJ, Sorensen SW, Williamson DF. Lifetime risk for diabetes mellitus in the United States. JAMA 2003, 290(14):1884-1890. 10.1001/jama.290.14.1884, 14532317.
-
(2003)
JAMA
, vol.290
, Issue.14
, pp. 1884-1890
-
-
Narayan, K.M.1
Boyle, J.P.2
Thompson, T.J.3
Sorensen, S.W.4
Williamson, D.F.5
-
24
-
-
52949091164
-
Prediction of individual genetic risk of complex disease
-
10.1016/j.gde.2008.07.006, 18682292
-
Wray NR, Goddard ME, Visscher PM. Prediction of individual genetic risk of complex disease. Curr Opin Genet Dev 2008, 18(3):257-263. 10.1016/j.gde.2008.07.006, 18682292.
-
(2008)
Curr Opin Genet Dev
, vol.18
, Issue.3
, pp. 257-263
-
-
Wray, N.R.1
Goddard, M.E.2
Visscher, P.M.3
-
25
-
-
54449097329
-
Accuracy of predicting the genetic risk of disease using a genome-wide approach
-
10.1371/journal.pone.0003395, 2561058, 18852893
-
Daetwyler HD, Villanueva B, Woolliams JA. Accuracy of predicting the genetic risk of disease using a genome-wide approach. PLoS One 2008, 3(10):e3395. 10.1371/journal.pone.0003395, 2561058, 18852893.
-
(2008)
PLoS One
, vol.3
, Issue.10
-
-
Daetwyler, H.D.1
Villanueva, B.2
Woolliams, J.A.3
-
26
-
-
29644440539
-
The Heritability of All-or-None Traits: Viability of Poultry
-
1209454, 17247323
-
Robertson A, Lerner IM. The Heritability of All-or-None Traits: Viability of Poultry. Genetics 1949, 34(4):395-411. 1209454, 17247323.
-
(1949)
Genetics
, vol.34
, Issue.4
, pp. 395-411
-
-
Robertson, A.1
Lerner, I.M.2
-
27
-
-
0030823158
-
Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium
-
10.1001/jama.1997.03550160069041, 9343467
-
Farrer LA, Cupples LA, Haines JL, Hyman B, Kukull WA, Mayeux R, Myers RH, Pericak-Vance MA, Risch N, van Duijn CM. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 1997, 278(16):1349-1356. 10.1001/jama.1997.03550160069041, 9343467.
-
(1997)
JAMA
, vol.278
, Issue.16
, pp. 1349-1356
-
-
Farrer, L.A.1
Cupples, L.A.2
Haines, J.L.3
Hyman, B.4
Kukull, W.A.5
Mayeux, R.6
Myers, R.H.7
Pericak-Vance, M.A.8
Risch, N.9
van Duijn, C.M.10
-
28
-
-
33947405732
-
Estimating risk of breast cancer in carriers of BRCA1 and BRCA2 mutations: a meta-analytic approach
-
10.1002/sim.2811, 17243094
-
Fu R, Harris EL, Helfand M, Nelson HD. Estimating risk of breast cancer in carriers of BRCA1 and BRCA2 mutations: a meta-analytic approach. Stat Med 2007, 26(8):1775-1787. 10.1002/sim.2811, 17243094.
-
(2007)
Stat Med
, vol.26
, Issue.8
, pp. 1775-1787
-
-
Fu, R.1
Harris, E.L.2
Helfand, M.3
Nelson, H.D.4
-
29
-
-
50049104725
-
Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study
-
10.1016/S1474-4422(08)70117-0, 2832754, 18539534
-
Healy DG, Falchi M, O'Sullivan SS, Bonifati V, Durr A, Bressman S, Brice A, Aasly J, Zabetian CP, Goldwurm S, Ferreira JJ, Tolosa E, Kay DM, Klein C, Williams DR, Marras C, Lang AE, Wszolek ZK, Berciano J, Schapira AH, Lynch T, Bhatia KP, Gasser T, Lees AJ, Wood NW, Consortium IL. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study. Lancet Neurol 2008, 7(7):583-590. 10.1016/S1474-4422(08)70117-0, 2832754, 18539534.
-
(2008)
Lancet Neurol
, vol.7
, Issue.7
, pp. 583-590
-
-
Healy, D.G.1
Falchi, M.2
O'Sullivan, S.S.3
Bonifati, V.4
Durr, A.5
Bressman, S.6
Brice, A.7
Aasly, J.8
Zabetian, C.P.9
Goldwurm, S.10
Ferreira, J.J.11
Tolosa, E.12
Kay, D.M.13
Klein, C.14
Williams, D.R.15
Marras, C.16
Lang, A.E.17
Wszolek, Z.K.18
Berciano, J.19
Schapira, A.H.20
Lynch, T.21
Bhatia, K.P.22
Gasser, T.23
Lees, A.J.24
Wood, N.W.25
Consortium, I.L.26
more..
-
31
-
-
0020083498
-
The meaning and use of the area under a receiver operating characteristic (ROC) curve
-
Hanley JA, McNeil BJ. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology 1982, 143(1):29-36.
-
(1982)
Radiology
, vol.143
, Issue.1
, pp. 29-36
-
-
Hanley, J.A.1
McNeil, B.J.2
-
32
-
-
0020826623
-
A numerically stable dual method for solving strictly convex quadratic programs
-
Goldfarb D, Idnani A. A numerically stable dual method for solving strictly convex quadratic programs. Math Program 1983, 27(1):33.
-
(1983)
Math Program
, vol.27
, Issue.1
, pp. 33
-
-
Goldfarb, D.1
Idnani, A.2
-
33
-
-
0032740874
-
Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study
-
10.1001/jama.282.15.1433, 10535433
-
Hu FB, Sigal RJ, Rich-Edwards JW, Colditz GA, Solomon CG, Willett WC, Speizer FE, Manson JE. Walking compared with vigorous physical activity and risk of type 2 diabetes in women: a prospective study. JAMA 1999, 282(15):1433-1439. 10.1001/jama.282.15.1433, 10535433.
-
(1999)
JAMA
, vol.282
, Issue.15
, pp. 1433-1439
-
-
Hu, F.B.1
Sigal, R.J.2
Rich-Edwards, J.W.3
Colditz, G.A.4
Solomon, C.G.5
Willett, W.C.6
Speizer, F.E.7
Manson, J.E.8
-
34
-
-
0034644185
-
Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland
-
10.1056/NEJM200007133430201, 10891514
-
Lichtenstein P, Holm NV, Verkasalo PK, Iliadou A, Kaprio J, Koskenvuo M, Pukkala E, Skytthe A, Hemminki K. Environmental and heritable factors in the causation of cancer-analyses of cohorts of twins from Sweden, Denmark, and Finland. New Engl J Med 2000, 343(2):78-85. 10.1056/NEJM200007133430201, 10891514.
-
(2000)
New Engl J Med
, vol.343
, Issue.2
, pp. 78-85
-
-
Lichtenstein, P.1
Holm, N.V.2
Verkasalo, P.K.3
Iliadou, A.4
Kaprio, J.5
Koskenvuo, M.6
Pukkala, E.7
Skytthe, A.8
Hemminki, K.9
|