Poly(I: C) combined with multi-epitope protein vaccine completely protects against virulent foot-and-mouth disease virus challenge in pigs

Antiviral Research

Volumn 97, Issue 2, 2013, Pages 145-153

  Cao, Yimei ^a   Lu, Zengjun ^a   Li, Yanli ^a   Sun, Pu ^a   Li, Dong ^a   Li, Pinghua ^a   Bai, Xingwen ^a   Fu, Yuanfang ^a   Bao, Huifang ^a   Zhou, Chunxue ^a   Xie, Baoxia ^a   Chen, Yingli ^a   Liu, Zaixin ^a  

^a INSTITUTE OF PLANT PROTECTION   (China)

Author keywords

FMDV; Multi epitope protein vaccine; Pig; Poly(I:C)

Indexed keywords

EPITOPE PROTEIN B4; FOOT AND MOUTH DISEASE VACCINE; POLYINOSINIC POLYCYTIDYLIC ACID; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CROSS REACTION; EXPERIMENTAL PIG; FOOT AND MOUTH DISEASE; IMMUNOGENICITY; NONHUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME; VACCINATION;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; EPITOPES; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; INJECTIONS, INTRAMUSCULAR; INTERFERON-ALPHA; INTERFERON-BETA; INTERFERON-GAMMA; POLY I-C; RECOMBINANT FUSION PROTEINS; SWINE; SWINE DISEASES; VACCINES, SYNTHETIC; VIRAL VACCINES;

ANIMALIA; FOOT-AND-MOUTH DISEASE VIRUS; SUIDAE;

EID: 84871869644     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2012.11.009     Document Type: Article

References (38)

1. Agadjanyan M.G., Ghochikyan A., Petrushina I., Vasilevko V., Movsesyan N., Mkrtichyan M., Saing T., Cribbs D.H. Prototype Alzheimer's disease vaccine using the immunodominant B cell epitope from β-amyloid and promiscuous T cell epitope pan HLA DR-binding peptide. J. Immunol. 2005, 174:1580-1586.
2. Alexandersen S., Zhang Z., Donaldson A.I., Garland A.J.M. The pathogenesis and diagnosis of foot-and-mouth disease. J. Comp. Pathol. 2003, 129:1-36.
3. Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappa B by Toll-like receptor 3. Nature 2001, 413:732-738.
4. Barteling S.J., Vreeswijk J. Developments in foot-and-mouth disease vaccines. Vaccine 1991, 9:75-88.
5. Cao Y.M., Lu Z.J., Li P.H., Sun P., Fu Y.F., Bai X.W., Bao H.F., Chen Y.L., Li D., Liu Z.X. Improved neutralising antibody response against foot-and-mouth-disease virus in mice inoculated with a multi-epitope peptide vaccine using polyinosinic and poly-cytidylic acid as an adjuvant. J. Virol. Methods 2012, 185:124-128.
6. Cao Y.M., Lu Z.J., Sun J.C., Bai X.W., Sun P., Bao H.F., Chen Y.L., Guo J.H., Liu X.T., Liu Z.X. Synthesis of empty capsid-like particles of Asia I foot-and-mouth disease virus in insect cells and their immunogenicity in guinea pigs. Vet. Microbiol. 2009, 137:10-17.
7. Cheng G., Zhao X., Yan W.Y., Wang W.F., Zuo X.P., Huang K., Liu Y., Chen J., Wang J.L., Cong W., Liu M.Q., Gao H.H., Chen J.L., Lu Y.G., Zheng Z.X. Alpha interferon is a powerful adjuvant for a recombinant protein vaccine against foot-and-mouth disease virus in swine, and an effective stimulus of in vivo immune response. Vaccine 2007, 25:5199-5208.
8. Collen T., Dimarchi R., Doel T.R. A T cell epitope in VP1 of foot-and-mouth disease virus is immunodominant for vaccinated cattle. J. Immunol. 1991, 146:749-755.
9. Cubillos C., de la Torre B.G., Jakab A., Clementi G., Borras E., Barcena J., Andreu D., Sobrino F., Blanco E. Enhanced mucosal immunoglobulin A response and solid protection against foot-and-mouth disease virus challenge induced by a novel dendrimeric peptide. J. Virol. 2008, 82:7223-7230.
10. Dias C.C., Moraes M.P., Weiss M., Diaz-San Segundo F., Perez-Martin E., Salazar A.M., de los Santos T., Grubman M.J. Novel antiviral therapeutics to control foot-and-mouth disease. J. Interferon Cytokine Res. 2012, 32:462-473.
11. Doel T.R. FMD vaccines. Virus Res. 2003, 91:81-99.
12. Eble P.L., Weerdmeester K., van Hemert-Kluitenberg F., Dekker A. Intradermal vaccination of pigs against FMD with 1/10 dose results in comparable vaccine efficacy as intramuscular vaccination with a full dose. Vaccine 2009, 27:1272-1278.
13. Golde W.T., Pacheco J.M., Duque H., Doel T., Penfold B., Ferman G.S., Gregg D.R., Rodriguez L.L. Vaccination against foot-and-mouth disease virus confers complete clinical protection in 7 days and partial protection in 4 days: use in emergency outbreak response. Vaccine 2005, 23:5775-5782.
14. Goodbourn S., Didcock L., Randall R.E. Interferons: cell signalling, immune modulation, antiviral responses and virus countermeasures. J. Gen. Virol. 2000, 81:2341-2364.
15. Grubman M.J. Development of novel strategies to control foot-and-mouth disease: marker vaccines and antivirals. Biologicals 2005, 33:227-234.
16. Grubman M.J., Baxt B. Foot-and-mouth disease. Clin. Microbiol. Rev. 2004, 17:465-493.
17. Hietela S.K., Ardans A.A. Molecular weapons against agricultural vulnerability and the war on terror. J. Vet. Med. Educ. 2003, 30:155-156.
18. Li D., Lu Z.J., Xie B.X., Sun P., Chen Y.L., Fu Y.F., Liu Z.X. Alternative way to test the efficacy of swine FMD vaccines: measurement of pigs median infected dose (PID50) and regulation of live virus challenge dose. Virol. J. 2010, 7:215.
19. Li D., Liu Z.X., Sun P., Li Y.L., Lu Z.J., Tian M.N., Chen Y.L., Xie B.X., Bao H.F., Fu Y.F., Cao Y.M., Li P.H., Bai X.W., Sun J.C., Guo J.H., Liu X.T., Xie Q.G. The efficacy of FMD vaccine reduced non-structural proteins with a mAb against 3B protein. Vet. Res. Commun. 2010, 34:445-457.
20. 4+ Th1 immunity with poly IC as adjuvant. J. Exp. Med. 2009, 206:1589-1602.
21. Lu Z.J., Cao Y.M., Guo J.H., Qi S.Y., Li D., Zhang Q., Ma J.W., Chang H.Y., Liu Z.X., Liu X.T., Xie Q.G. Development and validation of a 3ABC indirect ELISA for differentiation of foot-and-mouth disease virus infected from vaccinated animals. Vet. Microbiol. 2007, 125:157-169.
22. Mackay D.K.J., Forsyth M.A., Davies P.R., Berlinzani A., Belsham G.J., Flint M., Ryan M.D. Differentiating infection from vaccination in foot-and-mouth disease using a panel of recombinant, non-structural proteins in ELISA. Vaccine 1998, 16:446-459.
23. McCullough K.C., De Simone F., Brocchi E., Capucci L., Crowther J.R., Kihm U. Protective immune response against foot-and-mouth disease. J. Virol. 1992, 66:1835-1840.
24. Moonen P., Jacobs L., Crienen A., Dekker A. Detection of carriers of foot-and-mouth disease virus among vaccinated cattle. Vet. Microbiol. 2004, 103:151-160.
25. Moraes M.P., de los Santos T., Koster M., Turecek T., Wang H., Andreyev V.G., Grubman M.J. Enhanced antiviral activity against foot-and-mouth disease virus by a combination of type I and II porcine interferons. J. Virol. 2007, 81:7124-7135.
26. Mulcahy G., Gale C., Robertson P., Lysian S., DiMarchi R.D., Doel T.R. Isotype responses of infected, virus-vaccinated and peptidevaccinated cattle to foot-and-mouth disease virus. Vaccine 1990, 8:249-256.
27. Shao J.J., Wong C.K., Lin T., Lee S.K., Cong G.Z., Sin F.W.Y., Du J.Z., Gao S.D., Liu X.T., Cai X.P., Xie Y., Chang H.Y., Liu J.X. Promising multiple-epitope recombinant vaccine against foot-and-mouth disease virus type O in swine. Clin. Vaccine Immunol. 2011, 18:143-149.
28. Shen F., Chen P.D., Walfield A.M. Differentiation of convalescent animals from those vaccinated against foot-and-mouth disease by a peptide ELISA. Vaccine 1999, 17:3039-3049.
29. Sorensen K.J., Madsen K.G., Madsen E.S., Salt J.S., Nqindi J., Machay D.K.J. Differentiation of infection from vaccination in foot-and-mouth disease by the detection of antibodies to the non-structural proteins 3D, 3AB, 3ABC in ELISA using antigens expressed in baculovirus. Arch. Virol. 1998, 143:1461-1467.
30. Stark G.R., Kerr I.M., Williams B.R., Silverman R.H., Schreiber R.D. How cells respond to interferons. Annu. Rev. Biochem. 1998, 67:227-264.
31. Steward M.W., Stanley C.M., DiMarchi R., Mulcahy G., Doel T.R. High-affinity antibody induced by immunisation with a synthetic peptide is associated with protection of cattle against foot-and-mouth disease. Immunology 1991, 72:99-103.
32. Sun T., Lu P., Wang X. Localization of infection-related epitopes on the non-structural protein 3ABC of foot-and-mouth disease virus and the application of tandem epitopes. J. Virol. Methods 2004, 119:79-86.
33. Taboga O., Tami C., Carrillo E., Nunez J.I., Rodriguez A., Saiz J.C., Blanco E., Valero M.L., Roig X., Camarero J.A., Andreu D., Mateu M.G., Giralt E., Domingo E., Sobrino F., Palma E.L. A large-scale evaluation of peptide vaccines against foot-and-mouth disease: lack of solid protection in cattle and isolation of escape mutants. J. Virol. 1997, 71:2606-2614.
34. 4+ T cell responses to Plasmodium falciparum circum sporozoite protein (CSP) and αDEC-CSP in non human primates. Vaccine 2010, 2008:7256-7266.
35. Trumpfheller C., Longhi M.P., Caskey M., Idoyaga J., Bozzacco L., Keler T., Schlesinger S.J., Steinman R.M. Dendritic cell-targeted protein vaccines: a novel approach to induce T-cell immunity. J. Intern. Med. 2012, 271:183-192.
36. Wang C.Y., Chang T.Y., Walfield A.M., Ye J., Shen M., Chen S.P., Li M.C., Lin Y.L., Jong M.H., Yang P.C., Chyr N., Kramer E., Brown F. Effective synthetic peptide vaccine for foot-and-mouth disease in swine. Vaccine 2002, 20:2603-2610.
37. Zhang Z.D., Hutching G., Kitching P., Alexandersen S. The effects of gamma interferon on replication of foot-and-mouth disease virus in persistently infected bovine cells. Arch. Virol. 2002, 147:2157-2167.
38. Zheng H.X., He J.J., Guo J.H., Jin Y., Yang F., Lv L., Liu X.T. Genetic characterization of a new pandemic Southeast Asia topotype strain of serotype O foot-and-mouth disease virus isolated in China during 2010. Virus Genes 2012, 44:80-88.