JunB Mediates Basal- and TGFβ1-Induced Smooth Muscle Cell Contractility

PLoS ONE

Volumn 8, Issue 1, 2013, Pages

  Ramachandran, Aruna ^a,b   Gangopadhyay, Samudra S ^a,b   Krishnan, Ramaswamy ^b,c   Ranpura, Sandeep A ^a,b,d   Rajendran, Kavitha ^c   Ram Mohan, Sumati ^c   Mulone, Michelle ^a   Gong, Edward M ^a,b,e   Adam, Rosalyn M ^a  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^d SYNGENE INTERNATIONAL LTD   (India)

^e NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ALPHA SMOOTH MUSCLE ACTIN; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; CALPONIN; COFILIN; F ACTIN; G ACTIN; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; MYOSIN LIGHT CHAIN; RECOMBINANT TRANSFORMING GROWTH FACTOR BETA1; RHO KINASE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR JUNB; TRANSGELIN; TRICIRIBINE;

ACTIN FILAMENT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLADDER DISTENSION; CELL DIFFERENTIATION; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; RAT; RNA INTERFERENCE; SMOOTH MUSCLE CONTRACTILITY; SMOOTH MUSCLE CONTRACTION; SMOOTH MUSCLE FIBER;

ACTIN CYTOSKELETON; ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; CALCIUM-BINDING PROTEINS; GENE EXPRESSION REGULATION; HUMANS; MICROFILAMENT PROTEINS; MUSCLE CONTRACTION; MUSCLE PROTEINS; MYOCYTES, SMOOTH MUSCLE; MYOSIN LIGHT CHAINS; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; POLYMERIZATION; PRIMARY CELL CULTURE; RATS; RHO-ASSOCIATED KINASES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA1; URINARY BLADDER;

EID: 84871868115     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0053430     Document Type: Article

References (37)

1. Zderic SA, Chacko S, (2012) Alterations in the contractile phenotype of the bladder: lessons for understanding physiological and pathological remodelling of smooth muscle. J Cell Mol Med 16: 203-217.
2. Ramachandran A, Ranpura SA, Gong EM, Mulone M, Cannon GM Jr, et al. (2010) An Akt- and Fra-1-dependent pathway mediates platelet-derived growth factor-induced expression of thrombomodulin, a novel regulator of smooth muscle cell migration. Am J Pathol 177: 119-131.
3. Ramachandran A, Gong EM, Pelton K, Ranpura SA, Mulone M, et al. (2011) FosB regulates stretch-induced expression of extracellular matrix proteins in smooth muscle. Am J Pathol 179: 2977-2989.
4. Guo X, Chen SY, (2012) Transforming growth factor-beta and smooth muscle differentiation. World J Biol Chem 3: 41-52.
5. Grainger DJ, Metcalfe JC, Grace AA, Mosedale DE, (1998) Transforming growth factor-beta dynamically regulates vascular smooth muscle differentiation in vivo. J Cell Sci 111 (Pt 19): 2977-2988.
6. Langlois D, Hneino M, Bouazza L, Parlakian A, Sasaki T, et al. (2010) Conditional inactivation of TGF-beta type II receptor in smooth muscle cells and epicardium causes lethal aortic and cardiac defects. Transgenic Res 19: 1069-1082.
7. Akiho H, Deng Y, Blennerhassett P, Kanbayashi H, Collins SM, (2005) Mechanisms underlying the maintenance of muscle hypercontractility in a model of postinfective gut dysfunction. Gastroenterology 129: 131-141.
8. Parekh A, Long RA, Iannone EC, Chancellor MB, Sacks MS, (2009) Assessing the effects of transforming growth factor-beta1 on bladder smooth muscle cell phenotype. I. Modulation of in vitro contractility. J Urol 182: 1210-1215.
9. Biernacka A, Dobaczewski M, Frangogiannis NG, (2011) TGF-beta signaling in fibrosis. Growth Factors 29: 196-202.
10. Mack CP, Somlyo AV, Hautmann M, Somlyo AP, Owens GK, (2001) Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization. J Biol Chem 276: 341-347.
11. Hocevar BA, Howe PH, (2000) Regulation of AP-1 activity by TGF-beta. Methods Mol Biol 142: 97-108.
12. Chen S, Kulik M, Lechleider RJ, (2003) Smad proteins regulate transcriptional induction of the SM22alpha gene by TGF-beta. Nucleic Acids Res 31: 1302-1310.
13. Hu Y, Peng J, Feng D, Chu L, Li X, et al. (2006) Role of extracellular signal-regulated kinase, p38 kinase, and activator protein-1 in transforming growth factor-beta1-induced alpha smooth muscle actin expression in human fetal lung fibroblasts in vitro. Lung 184: 33-42.
14. Avouac J, Palumbo K, Tomcik M, Zerr P, Dees C, et al. (2012) Inhibition of activator protein 1 signaling abrogates transforming growth factor beta-mediated activation of fibroblasts and prevents experimental fibrosis. Arthritis Rheum 64: 1642-1652.
15. Fitzgibbon J, Morrison JJ, Smith TJ, O'Brien M, (2009) Modulation of human uterine smooth muscle cell collagen contractility by thrombin, Y-27632, TNF alpha and indomethacin. Reprod Biol Endocrinol 7: 2.
16. Trepat X, Wasserman MR, Angelini TE, Millet E, Weitz DA, et al. (2009) Physical forces during collective cell migration. Nature Phys 5: 426-430.
17. Adam RM, Eaton SH, Estrada C, Nimgaonkar A, Shih SC, et al. (2004) Mechanical stretch is a highly selective regulator of gene expression in human bladder smooth muscle cells. Physiol Genomics 20: 36-44.
18. Borer JG, Park JM, Atala A, Nguyen HT, Adam RM, et al. (1999) Heparin-binding EGF-like growth factor expression increases selectively in bladder smooth muscle in response to lower urinary tract obstruction. Lab Invest 79: 1335-1345.
19. Stehr M, Estrada CR, Khoury J, Danciu TE, Sullivan MP, et al. (2004) Caveolae are negative regulators of transforming growth factor-beta1 signaling in ureteral smooth muscle cells. J Urol 172: 2451-2455.
20. Lien SC, Usami S, Chien S, Chiu JJ, (2006) Phosphatidylinositol 3-kinase/Akt pathway is involved in transforming growth factor-beta1-induced phenotypic modulation of 10T1/2 cells to smooth muscle cells. Cell Signal 18: 1270-1278.
21. Kropp BP, Zhang Y, Tomasek JJ, Cowan R, Furness PD 3rd, et al (1999) Characterization of cultured bladder smooth muscle cells: assessment of in vitro contractility. J Urol 162: 1779-1784.
22. Kim JH, Jain D, Tliba O, Yang B, Jester WF Jr, et al. (2005) TGF-beta potentiates airway smooth muscle responsiveness to bradykinin. Am J Physiol Lung Cell Mol Physiol 289: L511-520.
23. Aceves SS, Chen D, Newbury RO, Dohil R, Bastian JF, et al. (2010) Mast cells infiltrate the esophageal smooth muscle in patients with eosinophilic esophagitis, express TGF-beta1, and increase esophageal smooth muscle contraction. J Allergy Clin Immunol 126: 1198-1204 e1194.
24. Mauviel A, Chung KY, Agarwal A, Tamai K, Uitto J, (1996) Cell-specific induction of distinct oncogenes of the Jun family is responsible for differential regulation of collagenase gene expression by transforming growth factor-beta in fibroblasts and keratinocytes. J Biol Chem 271: 10917-10923.
25. Pertovaara L, Sistonen L, Bos TJ, Vogt PK, Keski-Oja J, et al. (1989) Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation. Mol Cell Biol 9: 1255-1262.
26. Laiho M, Ronnstrand L, Heino J, Decaprio JA, Ludlow JW, et al. (1991) Control of junB and extracellular matrix protein expression by transforming growth factor-beta 1 is independent of simian virus 40 T antigen-sensitive growth-sensitive growth-inhibitory events. Mol Cell Biol 11: 972-978.
27. Shaulian E, Karin M, (2001) AP-1 in cell proliferation and survival. Oncogene 20: 2390-2400.
28. Gervasi M, Bianchi-Smiraglia A, Cummings M, Zheng Q, Wang D, et al. (2012) JunB contributes to Id2 repression and the epithelial-mesenchymal transition in response to transforming growth factor-beta. J Cell Biol 196: 589-603.
29. Licht AH, Nubel T, Feldner A, Jurisch-Yaksi N, Marcello M, et al. (2010) Junb regulates arterial contraction capacity, cellular contractility, and motility via its target Myl9 in mice. J Clin Invest 120: 2307-2318.
30. Gunst SJ, Zhang W, (2008) Actin cytoskeletal dynamics in smooth muscle: a new paradigm for the regulation of smooth muscle contraction. Am J Physiol Cell Physiol 295: C576-587.
31. Bernstein BW, Bamburg JR, (2010) ADF/cofilin: a functional node in cell biology. Trends Cell Biol 20: 187-195.
32. Connelly JT, Gautrot JE, Trappmann B, Tan DW, Donati G, et al. (2010) Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol 12: 711-718.
33. Camoretti-Mercado B, Dulin NO, Solway J, (2003) Serum response factor function and dysfunction in smooth muscle. Respir Physiol Neurobiol 137: 223-235.
34. Miralles F, Posern G, Zaromytidou AI, Treisman R, (2003) Actin dynamics control SRF activity by regulation of its coactivator MAL. Cell 113: 329-342.
35. Vartiainen MK, Guettler S, Larijani B, Treisman R, (2007) Nuclear actin regulates dynamic subcellular localization and activity of the SRF cofactor MAL. Science 316: 1749-1752.
36. Sotiropoulos A, Gineitis D, Copeland J, Treisman R, (1999) Signal-regulated activation of serum response factor is mediated by changes in actin dynamics. Cell 98: 159-169.
37. Baskin LS, Sutherland RS, Thomson AA, Hayward SW, Cunha GR, (1996) Growth factors and receptors in bladder development and obstruction. Lab Invest 75: 157-166.