Production of astragaloside and flavones from adventitious root cultures of Astragalus membranaceus var. mongholicus

Plant OMICS

Volumn 5, Issue 5, 2012, Pages 466-470

  Thwe, Aye Aye ^a   Mai, Nguyen Thi Thanh ^a   Li, Xiaohua ^a   Kim, Yeji ^a   Kim, Yeon Bok ^a   Uddin, Md Romij ^a   Kim, Young Seon ^b   Bae, Hanhong ^c   Kim, Haeng Hoon ^d   Lee, Mi Young ^b   Park, Sang Un ^a  

^a Chungnam National University   (South Korea)

^b Korea Institute of Oriental Medicine (KIOM)   (South Korea)

^c Yeungnam University   (South Korea)

^d Sunchon National University   (South Korea)

Author keywords

Adventitious root; Astragaloside; Astragalus membranaceus; Flavones

Indexed keywords

ASTRAGALUS MEMBRANACEUS; ASTRAGALUS MEMBRANACEUS VAR. MONGHOLICUS; ENGELHARDIA ROXBURGHIANA;

EID: 84871817066     PISSN: 18360661     EISSN: 18363644     Source Type: Journal    
DOI: None     Document Type: Article

References (31)

1. Amzallag G, Lerner N, Poljakoff-Mayber HRM (1992) Interaction between mineral nutrients, cytokinin and gibberillic acid during growth of sorghum at high NaCl salinity. J Exp Bot 43: 81-87.
2. Baskaran P, Jayabalan N (2005) Role of basal media, carbon sources and growth regulators in micropropagation of Eclipta alba - a valuable medicinal herb. KMITL Sci J 5(2): 469-482.
3. Chan LK, Dewi PR, Boey PL (2005) Effect of plant growth regulators on regeneration of plantlets from bud cultures of Cymbopogon nardus L.and the detection of essential oils from the in vitro plantlets. J Plant Biol 48:142-145.
4. Chen X, Peng LH, Li N, Li QM, Li P, Fung, KP, Leung PC,Gao JQ (2012) The healing and anti-scar effects of astragaloside IV on the wound repair in vitro and in vivo. J Ethnopharmacol 139:721-727.
5. Choi S, Park SR, Heo TR (2005) Inhibitory effect of astragali radix on matrix degradation in human articular cartilage. J Microbiol. Biotechnol 15: 1258-1266.
6. Dornenburg H, Knorr D (1995) Strategies for the improvement of secondary metabolite production in plant cell cultures. Enzyme Microbial Technol 17:674-684.
7. Fan Y, Wu DZ, Gong YQ, Zhou RY, Hu ZB (2003) Effects of calycosin on the impairment of barrier function induced by hypoxia in human umbilical vein endothelial cells. Eur J Pharmacol 481: 33-40.
8. Gamborg OL, Miller RA, Ojima K (1968) Nutrient requirement of suspension cultures of soybean root cells.Exp Cell Res 50: 151-158.
9. Hahn EJ, Kim YS, Yu KW, Jeong CS, Paek KY (2003) Adventitious root cultures of Panax ginseng, Meyer CA and ginsenoside production through large scale bioreactor systems. J Plant Biotechnol 5: 1-6.
10. Khalafalla MM, Daffalla HM, El-Shemy HA, Abdellatef E (2009) Establishment of in vitro fast-growing normal root culture of Vernonia amygdalina - a potent African medicinal plant. African J Biotechnol 8 (21):5952-5957.
11. Kim JH, Kim MR, Lee ES, Lee CH (2009) Effects of Calycosin Isolated from the Root of Astragalus membranaceus on Melanin Biosynthesis. Biol Pharmaceut Bull 32(2): 264-268.
12. Kim YS, Hahn EJ, Yeung EC, Paek KY (2003) Lateral root development and saponin accumulation as affected by IBA or NAA in adventitious root cultures of Panax ginseng CA Meyer. In Vitro Cell Dev Biol Plant 39: 245-249.
13. Kitto SL,Young MJ (1981) In vitro propagation of Carrizo citrange. Hort Science 16: 305-306.
14. Kusakari K, Yokoyama M, Inomata S (2000) Enhanced Production of saikosaponin in cultured roots of Bupleurum falcatum L. using two-step control of sugar concentration Plant Cell Rep. 19: 1115-1120.
15. Lee YM, Choi SI, Lee JW, Jung SM, Park SM, Heo TR (2005) Isolation of hyaluronidase inhibitory component from the roots of Astraglus membranaceus Bunge Astragali radix. Food Sci Biotechnol 14: 263-267.
16. Luo Y, Qin Z, Hong Z, Zhang XM, Ding D, Fu JH, Zhang WD, Chen J (2004) Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neurosci Lett 363: 218-223.
17. Ma XQ, Duan JA, Zhu DY, Dong TTX, Tsim KWK (2000) Species identification of Radix Astragali (Huang-qi) by DNA sequence of its 5S-rRNA spacer domain. Phytochem 54: 363-368.
18. Murashige T, Skoog F (1962) A revised medium for rapid growth and bioassays with tobacco tissue cultures. Physiol Plant 15: 473-497.
19. Murthy HN, Hahn EJ, Paek KY (2008) Adventitious roots and secondary metabolism. Chinese J Biotechnol 24: 711-716.
20. Nakamura T, Hashimoto A, Nishi H, Kokusenya Y (1999) Investigation on the marker substances of crude drugs in formulations. I. Marker substances for the identification of Astragali Radix in kampo and drinkable preparations. J Pharmaceut Soc Jap 119:391-400.
21. Qu YZ, Li M, Zhao YL, Zhao ZW, Wei XY, Liu JP, Gao L, Gao GD (2009) Astragaloside IV attenuates cerebral ischemia-reperfusion-induced increase in permeability of the blood-brain barrier in rats. Eur J Pharmacol 606: 137-141.
22. Schenk RU, Hildebrandt AC (1972) Medium and techniques for induction and growth of monocotyledons and dicotyledonous plant cell cultures. Can J Bot 50: 199-204.
23. Taylor JLS, van Staden J (1998) Plant-derived smoke solutions stimulate the growth of Lycopersicon esculentum roots in vitro. Plant Growth Reg 26: 77-83.
24. Toda S, Shirataki Y (1998) Inhibitory effects of isoflavones in roots of Astragalus membranaceus Bunge (Astragali Radix) on lipid peroxidation by reactive oxygen species. Phytother Res 12:59-61.
25. Wagner H, Bauer R, Xiao PG, Chen JM, Michler G (1997) Chinese Drug Monographs and Analysis: Radix Astragali (Huangqi); Verlag Wald Germany pp 1-17.
26. Wu CH, Dewir YH, Hanh EJ, Paek KY (2006) Optimization of culturing conditions for the production of biomass and phenolics from adventitious roots of Echinacea angustifolia. J Plant Biol 49(3): 193-199.
27. Wu DZ, Fan Y, Hen ZF, Song CQ, Hu ZB (2000) Effect of flavonoids isolated from Astragalus membranaceus on the changes of endothelial permeability induced by low osmolarity. Pharmacol Clin Chin Mater Med 16:16-18.
28. Yu KW, Hahn EJ, Paek KY (2005) Production of adventitious roots using bioreacters. Korean J Plant Tissue Cult 27: 309-315.
29. Zhang WD, Chen H, Zhang C, Li HL, Liu RH, Chen HZ (2006) Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta Med 72: 4-8.
30. Zheng XY (2005) Pharmacopoeia of the Peoples Republic of China, Vol. 1, Chinese edn. Beijing: Chemical Industry Press 212-213.
31. Zhou JY, Fan Y, Kong JL, Wu DZ, Hu ZB (2000) Effects of components isolated from Astragalus membranaceus Bunge on cardiac function injured by myocardial ischemia reperfusion in rats. Chin J Chin Mater Med 25:300-302.