New modified β-cyclodextrin derivatives as detoxifying agents of chemical warfare agents (I). Synthesis and preliminary screening: Evaluation of the detoxification using a half-quantitative enzymatic assay

Toxicology Letters

Volumn 216, Issue 2-3, 2013, Pages 200-205

  Kalakuntla, Raman Kumar ^a,b,c   Wille, Timo ^d   Le Provost, Romain ^a,b,c   Letort, Sophie ^a,b,c   Reiter, Georg ^d   Müller, Susanne ^d   Thiermann, Horst ^d   Worek, Franz ^d   Gouhier, Géraldine ^a,b,c   Lafont, Olivier ^a   Estour, François ^a,b,c  

^a UNIVERSITÉ DE ROUEN   (France)

^b UNIVERSITÉ ET INSA DE ROUEN   (France)

^c CNRS   (France)

^d BUNDESWEHR INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY   (Germany)

Author keywords

Chemical scavenger; Cyclodextrin; Detoxification; Inclusion and non inclusion complexes; Organophosphorus compound

Indexed keywords

ACETYLCHOLINESTERASE; BETA CYCLODEXTRIN DERIVATIVE; CYCLOSARIN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; OLIGOSACCHARIDE; ORGANOPHOSPHORUS COMPOUND; SOMAN; TABUN;

ARTICLE; CHEMICAL WARFARE; DETOXIFICATION; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYMATIC ASSAY; ENZYME ACTIVITY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ASSAY;

ACETYLCHOLINESTERASE; BETA-CYCLODEXTRINS; CHEMICAL WARFARE AGENTS; CHOLINESTERASE INHIBITORS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; ORGANOPHOSPHORUS COMPOUNDS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STEREOISOMERISM;

EID: 84871811594     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2012.11.020     Document Type: Article

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