Application of simple biomechanical and biochemical tests to heart valve leaflets: Implications for heart valve characterization and tissue engineering

Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine

Volumn 226, Issue 11, 2012, Pages 868-876

  Huang, Hsiao Ying S ^a   Balhouse, Brittany N ^b   Huang, Siyao ^a  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

collagen; Heart valves; mechanical property; microstructure; real time maps

Indexed keywords

AORTIC VALVES; BIOCHEMICAL PROPERTIES; BIOCHEMICAL TESTS; BIOMECHANICAL TESTS; COLLAGEN CONCENTRATION; DISPLACEMENT VECTORS; EXTRACTION TIME; HEART VALVES; MECHANICAL BEHAVIOR; MECHANICAL CHARACTERIZATIONS; PRINCIPAL STRAIN DIRECTION; STRAIN MAPPING; TIME POINTS; TISSUE-ENGINEERED HEART; REAL TIME;

ANISOTROPY; BLOOD VESSELS; COLLAGEN; HEART; HISTOLOGY; MECHANICAL ENGINEERING; MECHANICAL PROPERTIES; MICROSTRUCTURE; TISSUE; TISSUE ENGINEERING; VALVES (MECHANICAL); BIOMECHANICS; EXTRACTION;

BIOMECHANICS; VALVES (MECHANICAL);

COLLAGEN;

ANIMAL; ARTICLE; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HEART VALVE; HISTOLOGY; IN VITRO STUDY; INSTRUMENTATION; METHODOLOGY; PHYSIOLOGY; STIMULATION; SWINE; TISSUE ENGINEERING;

ANIMALS; COLLAGEN; EQUIPMENT DESIGN; EQUIPMENT FAILURE ANALYSIS; HEART VALVES; PHYSICAL STIMULATION; SWINE; TISSUE ENGINEERING;

EID: 84871798691     PISSN: 09544119     EISSN: 20413033     Source Type: Journal    
DOI: 10.1177/0954411912455004     Document Type: Article

References (38)

1. Sacks MS, Merryman WD, Schmidt DE. On the biomechanics of heart valve function. J Biomech. 2009 ; 42 (12). 1804-1824
2. Schoen FJ. Mechanisms of function and disease of natural and replacement heart valves. Annu Rev Pathol. 2012 ; 7: 161-183
3. Lewinsohn AD, Anssari-Benham A, Lee DA, et al. Anisotropic strain transfer through the aortic valve and its relevance to the cellular mechanical environment. Proc. IMechE, Part H: J Engineering in Medicine. 2011 ; 225 (8). 821-830
4. Koch TM, Reddy BD, Zilla P, et al. Aortic valve leaflet mechanical properties facilitate diastolic valve function. Comput Methods Biomech Biomed Engin. 2010 ; 13 (2). 225-234
5. Stella JA, Sacks MS. On the biaxial mechanical properties of the layers of the aortic valve leaflet. J Biomech Eng. 2007 ; 129 (5). 757-766 (Pubitemid 350005837)
6. Doehring TC, Kahelin M, Vesely I. Mesostructures of the aortic valve. J Heart Valve Dis. 2005 ; 14 (5). 679-686 (Pubitemid 41601121)
7. Joyce EM, Liao J, Schoen FJ, et al. Functional collagen fiber architecture of the pulmonary heart valve cusp. Ann Thorac Surg. 2009 ; 87 (4). 1240-1249
8. Latif N, Sarathchandra R, Taylor RM, et al. Molecules mediating cell-ECM and cell-cell communication in human heart valves. Cell Biochem Biophys. 2005 ; 43 (2). 275-287 (Pubitemid 41095267)
9. Huang H-Y, Liao J, Sacks MS. In-situ deformation of the aortic valve interstitial cell nucleus under diastolic loading. J Biomech Eng. 2007 ; 129: 880-889 (Pubitemid 351153476)
10. Filip DA, Radu A, Simionescu M. Interstitial-cells of the heart-valves possess characteristics similar to smooth-muscle cells. Circ Res. 1986 ; 59 (3). 310-320 (Pubitemid 17178125)
11. Gross L, Kugel MA. Topographical anatomy and histology of the valves in the human heart. Am J Pathol. 1931 ; 7: 445-474
12. Sacks MS, Schoen FJ, Mayer JE. Bioengineering challenges for heart valve tissue engineering. Annu Rev Biomed Eng. 2009 ; 11: 289-313
13. Langer R, Vacanti JP. Tissue engineering. Science. 1993 ; 260 (5110). 920-926 (Pubitemid 23209960)
14. Schoen FJ, Levy RJ. Calcification of tissue heart valve substitutes: progress toward understanding and prevention. Ann Thorac Surg. 2005 ; 79 (3). 1072-1080 (Pubitemid 40288798)
15. Sacks MS. The biomechanical effects of fatigue on the porcine bioprosthetic heart valve. J Long Term Eff Med Implants. 2001 ; 11 (3-4). 231-247 (Pubitemid 34211357)
16. Dasi LP, Simon HA, Sucosky P, et al. Fluid mechanics of artificial heart valves. Clin Exp Pharmacol Physiol. 2009 ; 36 (2). 225-237
17. Perron J, Moran AM, Gauvreau K, et al. Valved homograft conduit repair of the right heart in early infancy. Ann Thorac Surg. 1999 ; 68 (2). 542-548 (Pubitemid 29521107)
18. Shinoka T, Breuer CK, Tanel RE, et al. Tissue engineering heart valves: valve leaflet replacement study in a lamb model. Ann Thorac Surg. 1995 ; 60: S513 - S516
19. Colazzo F, Sarathchandra P, Smolenski RT, et al. Extracellular matrix production by adipose-derived stem cells: implications for heart valve tissue engineering. Biomaterials. 2011 ; 32 (1). 119-127
20. Berry JL, Steen JA, Williams JK, et al. Bioreactors for development of tissue engineered heart valves. Ann Biomed Eng. 2010 ; 38 (11). 3272-3279
21. Sauren A, Hout MC, Steenhaven AA, et al. The mechanical properties of porcine aortic valve tissues. J Biomech. 1983 ; 16: 327-337 (Pubitemid 13036575)
22. Sacks MS. Incorporation of experimentally-derived fiber orientation into a structural constitutive model for planar collagenous tissues. J Biomech Eng. 2003 ; 125 (2). 280-287 (Pubitemid 36506143)
23. Sacks MS, Sun W. Multiaxial mechanical behavior of biological materials. Annu Rev Biomed Eng. 2003 ; 5: 251-284 (Pubitemid 40125313)
24. Grashow JS, Sacks MS, Liao J, et al. Planar biaxial creep and stress relaxation of the mitral valve anterior leaflet. Ann Biomed Eng. 2006 ; 34 (10). 1509-1518
25. Sacks MS. Biaxial mechanical evaluation of planar biological materials. J Elast. 2000 ; 61: 199-246 (Pubitemid 32723829)
26. Eilaghi A, Flanagan JG, Brodland GW, et al. Strain uniformity in biaxial specimens is highly sensitive to attachment details. J Biomech Eng. 2009 ; 131 (9). 091003
27. Eilaghi A, Flanagan JG, Tertinegg I, et al. Biaxial mechanical testing of human sclera. J Biomech. 2010 ; 43 (9). 1696-1701
28. Gregory DE, Veldhuis JH, Horst C, Brodland GW, Callaghan JP. Novel lap test determines the mechanics of delamination between annular lamellae of the intervertebral disc. Journal of Biomechanics. 2011 ; 44: 97-102
29. Sun W, Sacks MS, Scott MJ. Effects of boundary conditions on the estimation of the planar biaxial mechanical properties of soft tissues. J Biomech Eng. 2005 ; 127 (4). 709-715 (Pubitemid 41116931)
30. Brown AN, Kim BS, Alsberg E, et al. Combining chondrocytes and smooth muscle cells to engineer hybrid soft tissue constructs. Tissue eng. 2000 ; 6 (4). 297-305 (Pubitemid 30655940)
31. Engelmayr GC, Rabkin E, Sutherland FW, et al. The independent role of cyclic flexure in the early in vitro development of an engineered heart valve tissue. Biomaterials. 2005 ; 26 (2). 175-187 (Pubitemid 38789100)
32. Engelmayr GC, Papworth GD, Watkins SC, et al. Guidance of engineered tissue collagen orientation by large-scale scaffold microstructures. J Biomech. 2005 ; 39: 1819-1831 (Pubitemid 43946434)
33. Balguid A, Mol A, Van Vlimmeren MAA, et al. Hypoxia induces near-native mechanical properties in engineered heart valve tissue. Circulation. 2009 ; 119 (2). 290-297
34. Christie GW, Barratt-Boyes BG. Mechanical properties of porcine pulmonary valve leaflets: how do they differ from aortic leaflets?. Ann Thorac Surg. 1995 ; 60 (0003-4975). S195 - S199
35. Sacks MS, Smith DB, Hiester ED. The aortic valve microstructure: effects of transvalvular pressure. J Biomed Mater Res. 1998 ; 41 (1). 131-141 (Pubitemid 28255903)
36. Billiar KL, Sacks MS. Biaxial mechanical properties of the natural and glutaraldehyde treated aortic valve cusp - part I: experimental results. J Biomech Eng. 2000 ; 122 (1). 23-30 (Pubitemid 30204698)
37. Stradins P, Lacis R, Ozolanta I, et al. Comparison of biomechanical and structural properties between human aortic and pulmonary valve. Eur J Cardiothorac Surg. 2004 ; 26 (3). 634-639 (Pubitemid 39092006)
38. Balguid A, Rubbens MP, Mol A, et al. The role of collagen cross-links in biomechanical behavior of human aortic heart valve leaflets - relevance for tissue engineering. Tissue Eng. 2007 ; 13 (7). 1501-1511 (Pubitemid 47105758)