Clonal Human Fetal Ventral Mesencephalic Dopaminergic Neuron Precursors for Cell Therapy Research

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  Ramos Moreno, Tania ^a   Lendínez, Javier G ^a,c   Pino Barrio, María José ^a,d   del Arco, Araceli ^b   Martínez Serrano, Alberto ^a  

^a UNIVERSIDAD AUTÓNOMA DE MADRID   (Spain)

^b UNIVERSITY OF CASTILLA LA MANCHA   (Spain)

^c UNIVERSITY OF EDINBURGH   (United Kingdom)

^d CIEMAT   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

NEURON SPECIFIC ENOLASE; ONCOPROTEIN; TYROSINE 3 MONOOXYGENASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL CYCLE; CLONE; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DOWN REGULATION; FEMALE; FETUS; GENE DOSAGE; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MESENCEPHALON; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL TRANSPLANTATION; NONHUMAN; PARKINSON DISEASE; PROTEIN EXPRESSION; RAT; V MYC GENE; VENTRAL MESENCEPHALON;

ANIMALS; CELL CYCLE CHECKPOINTS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; DOPAMINERGIC NEURONS; DOWN-REGULATION; FEMALE; GENE DOSAGE; GENE EXPRESSION; HUMANS; INTERMEDIATE FILAMENT PROTEINS; KI-67 ANTIGEN; MESENCEPHALON; NERVE TISSUE PROTEINS; NEURAL STEM CELLS; ONCOGENE PROTEIN P55(V-MYC); PARKINSON DISEASE, SECONDARY; RATS; RATS, SPRAGUE-DAWLEY; STEM CELL RESEARCH;

PARKINSONIA; RATTUS;

EID: 84871792575     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052714     Document Type: Article

References (37)

1. Politis M, Lindvall O, (2012) Clinical application of stem cell therapy in Parkinson's disease. BMC Med 10: 1.
2. Lindvall O, Bjorklund A, (2011) Cell therapeutics in Parkinson's disease. Neurotherapeutics 8: 539-548.
3. Gogel S, Gubernator M, Minger SL, (2011) Progress and prospects: stem cells and neurological diseases. Gene Ther 18: 1-6.
4. Gaillard A, Jaber M, (2011) Rewiring the brain with cell transplantation in Parkinson's disease. Trends Neurosci 34: 124-133.
5. Wakeman DR, Dodiya HB, Kordower JH, (2011) Cell transplantation and gene therapy in Parkinson's disease. Mt Sinai J Med 78: 126-158.
6. Lindvall O, Kokaia Z, (2010) Stem cells in human neurodegenerative disorders-time for clinical translation? J Clin Invest 120: 29-40.
7. Arenas E, (2010) Towards stem cell replacement therapies for Parkinson's disease. Biochem Biophys Res Commun 396: 152-156.
8. Seiz EG, Ramos-Gomez M, Courtois ET, Tonnesen J, Kokaia M, et al. (2012) Human midbrain precursors activate the expected developmental genetic program and differentiate long-term to functional A9 dopamine neurons in vitro. Enhancement by Bcl-X(L). Exp Cell Res 318: 2446-2459.
9. Lepski G, Maciaczyk J, Jannes CE, Maciaczyk D, Bischofberger J, et al. (2011) Delayed functional maturation of human neuronal progenitor cells in vitro. Mol Cell Neurosci 47: 36-44.
10. Brundin P, Strecker RE, Widner H, Clarke DJ, Nilsson OG, et al. (1988) Human fetal dopamine neurons grafted in a rat model of Parkinson's disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release. Exp Brain Res 70: 192-208.
11. Winkler C, Kirik D, Bjorklund A, (2005) Cell transplantation in Parkinson's disease: how can we make it work? Trends Neurosci 28: 86-92.
12. Kallur T, Darsalia V, Lindvall O, Kokaia Z, (2006) Human fetal cortical and striatal neural stem cells generate region-specific neurons in vitro and differentiate extensively to neurons after intrastriatal transplantation in neonatal rats. J Neurosci Res 84: 1630-1644.
13. Goldring CE, Duffy PA, Benvenisty N, Andrews PW, Ben-David U, et al. (2011) Assessing the safety of stem cell therapeutics. Cell Stem Cell 8: 618-628.
14. Lindvall O, Barker RA, Brustle O, Isacson O, Svendsen CN, (2012) Clinical translation of stem cells in neurodegenerative disorders. Cell Stem Cell 10: 151-155.
15. Lindvall O, (2012) Why is it taking so long to develop clinically competitive stem cell therapies for CNS disorders? Cell Stem Cell 10: 660-662.
16. Martinez-Serrano A LI, (2010) Recent progress and challenges for the use of stem cell derivatives in neuron replacement therapy for Parkinson's disease. Future Neurol 5: 161-165.
17. Villa A, Liste I, Courtois ET, Seiz EG, Ramos M, et al. (2009) Generation and properties of a new human ventral mesencephalic neural stem cell line. Exp Cell Res 315: 1860-1874.
18. Martinez-Serrano A, Castillo CG, Courtois ET, Garcia-Garcia E, Liste I, (2011) Modulation of the generation of dopaminergic neurons from human neural stem cells by Bcl-X(L): mechanisms of action. Vitam Horm 87: 175-205.
19. Ramos-Moreno T, Castillo CG, Martinez-Serrano A, (2012) Long term behavioral effects of functional dopaminergic neurons generated from human neural stem cells in the rat 6-OH-DA Parkinson's disease model. Effects of the forced expression of BCL-X(L). Behav Brain Res 232: 225-232.
20. Courtois ET, Castillo CG, Seiz EG, Ramos M, Bueno C, et al. (2010) In vitro and in vivo enhanced generation of human A9 dopamine neurons from neural stem cells by Bcl-XL. J Biol Chem 285: 9881-9897.
21. Yan J, Studer L, McKay RD, (2001) Ascorbic acid increases the yield of dopaminergic neurons derived from basic fibroblast growth factor expanded mesencephalic precursors. J Neurochem 76: 307-311.
22. Ostenfeld T, Joly E, Tai YT, Peters A, Caldwell M, et al. (2002) Regional specification of rodent and human neurospheres. Brain Res Dev Brain Res 134: 43-55.
23. Chung S, Shin BS, Hwang M, Lardaro T, Kang UJ, et al. (2006) Neural precursors derived from embryonic stem cells, but not those from fetal ventral mesencephalon, maintain the potential to differentiate into dopaminergic neurons after expansion in vitro. Stem Cells 24: 1583-1593.
24. Baizabal JM, Cano-Martinez A, Valencia C, Santa-Olalla J, Young KM, et al. (2012) Glial commitment of mesencephalic neural precursor cells expanded as neurospheres precludes their engagement in niche-dependent dopaminergic neurogenesis. Stem Cells Dev 21: 1047-1058.
25. Kim HJ, McMillan E, Han F, Svendsen CN, (2009) Regionally specified human neural progenitor cells derived from the mesencephalon and forebrain undergo increased neurogenesis following overexpression of ASCL1. Stem Cells 27: 390-398.
26. Hebsgaard JB, Nelander J, Sabelstrom H, Jonsson ME, Stott S, et al. (2009) Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics. Glia 57: 1648-1658.
27. Ribeiro D, Laguna Goya R, Ravindran G, Vuono R, Parish CL, et al. (2012) Efficient expansion and dopaminergic differentiation of human fetal ventral midbrain neural stem cells by midbrain morphogens. Neurobiol Dis 49C: 118-127.
28. Fricker RA, Carpenter MK, Winkler C, Greco C, Gates MA, et al. (1999) Site-specific migration and neuronal differentiation of human neural progenitor cells after transplantation in the adult rat brain. J Neurosci 19: 5990-6005.
29. Rubio FJ, Bueno C, Villa A, Navarro B, Martinez-Serrano A, (2000) Genetically perpetuated human neural stem cells engraft and differentiate into the adult mammalian brain. Mol Cell Neurosci 16: 1-13.
30. Svendsen CN, Clarke DJ, Rosser AE, Dunnett SB, (1996) Survival and differentiation of rat and human epidermal growth factor-responsive precursor cells following grafting into the lesioned adult central nervous system. Exp Neurol 137: 376-388.
31. Sanchez-Pernaute R, Studer L, Bankiewicz KS, Major EO, McKay RD, (2001) In vitro generation and transplantation of precursor-derived human dopamine neurons. J Neurosci Res 65: 284-288.
32. Miljan EA, Hines SJ, Pande P, Corteling RL, Hicks C, et al. (2009) Implantation of c-mycER TAM immortalized human mesencephalic-derived clonal cell lines ameliorates behavior dysfunction in a rat model of Parkinson's disease. Stem Cells Dev 18: 307-319.
33. Villa A, Snyder EY, Vescovi A, Martinez-Serrano A, (2000) Establishment and properties of a growth factor-dependent, perpetual neural stem cell line from the human CNS. Exp Neurol 161: 67-84.
34. Blakemore C, Clark JM, Nevalainen T, Oberdorfer M, Sussman A, (2012) Implementing the 3Rs in Neuroscience Research: A Reasoned Approach. Neuron 75: 948-950.
35. Villa A, Navarro-Galve B, Bueno C, Franco S, Blasco MA, et al. (2004) Long-term molecular and cellular stability of human neural stem cell lines. Exp Cell Res 294: 559-570.
36. Cacci E, Villa A, Parmar M, Cavallaro M, Mandahl N, et al. (2007) Generation of human cortical neurons from a new immortal fetal neural stem cell line. Exp Cell Res 313: 588-601.
37. Liste I, Garcia-Garcia E, Bueno C, Martinez-Serrano A, (2007) Bcl-XL modulates the differentiation of immortalized human neural stem cells. Cell Death Differ 14: 1880-1892.