Characterizing an Agar/Gelatin phantom for image guided dosing and feedback control of high-intensity focused ultrasound

Ultrasound in Medicine and Biology

Volumn 39, Issue 2, 2013, Pages 300-311

  Dunmire, Barbrina ^a   Kucewicz, John C ^a   Mitchell, Stuart B ^a   Crum, Lawrence A ^a   Sekins, K Michael ^b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b Ultrasound Business Unit   (United States)

Author keywords

High intensity focused ultrasound (HIFU); Hydrogel; Temperature dependence; Tissue mimicking phantom; Ultrasound

Indexed keywords

ELASTIC MODULI; ELECTRIC POWER FACTOR; HYDROGELS; MANUFACTURE; SHEAR STRAIN; TEMPERATURE DISTRIBUTION; TISSUE; ULTRASONIC TESTING; ULTRASONIC VELOCITY MEASUREMENT; ULTRASONICS;

HIGH INTENSITY FOCUSED ULTRASOUND; IMAGE-GUIDED; MATERIAL PROPERTY; PARABOLIC DEPENDENCE; POWER FACTORS; ROOM TEMPERATURE; SOUND SPEED; TEMPERATURE DEPENDENCE; TISSUE MIMICKING PHANTOM; ULTRASOUND GUIDED;

THERMAL CONDUCTIVITY;

AGAR; GELATIN; WATER;

ARTICLE; ATTENUATION; CONTROLLED STUDY; DIFFUSION; HEATING; HIGH INTENSITY FOCUSED ULTRASOUND; HIGH TEMPERATURE; INCUBATION TEMPERATURE; LOW TEMPERATURE; MATERIAL STATE; PHANTOM; PHYSICAL PHENOMENA; PRIORITY JOURNAL; ROOM TEMPERATURE; SHEAR MODULUS; SOUND; THERMAL CONDUCTIVITY;

EID: 84871790216     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2012.09.016     Document Type: Article

References (41)

1. Akintunde M.A. Modeling of thermal properties of food components. Pacific J Sci Tech (PJST) 2008, 9:629-639.
2. Aymmard P., Martin D.R., Plucknett K., Foster T.J., Clark A.H., Norton I.T. Influence of thermal history on the structural and mechanical properties of agarose gels. Biopolymers 2001, 59:131-144.
3. Berlin E., Kliman G.P., Pallansch M.J. Effect of sorbed water on the heat capacity of crystalline proteins. Thermochim Acta 1972, 4:11-16.
4. Bouchard L.S., Bronskill M.J. Magnetic resonance imaging of thermal coagulation effects in a phantom for calibrating thermal therapy devices. Med Phys 2000, 27:1141-1145.
5. Brewin M.P., Pike L.C., Rowland D.E., Birch M.J. The acoustic properties, centered on 20 MHz, of an IEC agar-based tissue mimicking material and its temperature, frequency, and age dependence. Ultrasound Med Biol 2008, 34:1292-1306.
6. Browne J., Ramnarine K., Watson A., Hoskins P. Assessment of the acoustic properties of common tissue-mimicking test phantoms. Ultrasound Med Biol 2003, 29:1053-1060.
7. Casciaro S., Conversano F., Musio S., Casciaro E., Demitri C., Sannino A. Full experimental modeling of a liver tissue mimicking phantom for medical ultrasound studies employing different hydrogels. J Mater Sci Mater Med 2009, 20:983-989.
8. Choi I., Shield R.T. Second-order effects in problems for a class of elastic materials. J Applied Math Phys (ZAMP) 1981, 32:361-380.
9. Culjat M.O., Goldenberg D., Tweari P., Singh R.S. A review of tissue substitutes for ultrasound imaging. Ultrasound Med Biol 2010, 36:861-873.
10. Damianou C.A., Sanghvi N.T., Fry F.J., Maass-Moreno R. Dependence of ultrasonic attenuation and absorption in dog soft tissues on temperature and thermal dose. J Acoust Soc Am 1997, 102:628-634.
11. Dong F., Madsen E.L., MacDonald M.C., Zagzebski A. Nonlinearity parameter for tissue mimicking materials. Ultrasound Med Biol 1999, 25:831-838.
12. Elansari A.M., Hobani A.I. Effect of temperature and moisture content on thermal conductivity of four types of meat. Int J Food Prop 2009, 12:308-315.
13. Etzler F.M., Conners J.J. Temperature dependence of the heat capacity of water in small pores. Langmuir 1990, 6:1250-1253.
14. Fan L., Hsu S.J., Zeng X.J., Lee C.-Y., Sutedja R., Kook J., Sekins M. A method for automated detection of high intensity focused ultrasound (HIFU) beams in 3D space. Proc IEEE Ultrason Symp 2010, 471-474.
15. Fan L., Sekins M.K. Real-time tissue thermometry using an acoustic neural network method during HIFU treatment. AIP Conference Proc 2010, 1215:391-395.
16. Farny C.H., Clement G.T. Ultrasound phase contrast thermal imaging with reflex transmission imaging methods in tissue phantoms. Ultrasound Med Biol 2009, 35:1995-2006.
17. Food and foodstuff - specific heats (n.d.). Available at: (accessed Sept 2012). http://www.engineeringtoolbox.com.
18. Fujino J, Honda T. Measurement of specific heat capacity of gelatin for human phantom using differential scanning calorimetry. Presented at the 18th Symposium on Thermophysical Properties, June 2012, Boulder, Co. Abstract available at (accessed Sept 2012). http://thermosymposium.nist.gov/pdf/Abstract_1242.pdf.
19. Guo Z., Moreau M., Rickey D.W., Picot P.A., Fenster A. Quantitative investigation of in vitro flow using three-dimensional colour Doppler ultrasound. Ultrasound Med Biol 1995, 21:807-816.
20. Hall T.J., Bilgen M., Insana M.F., Krouskop T.A. Phantom materials for elastography. IEEE Trans Ultrason Ferroelectr Freq Control 1997, 44:1355-1365.
21. Holmes KR. Thermal Properties. Unpublished manuscript. Available at (n.d.) (accessed Sept 2012). http://users.ece.utexas.edu/~valvano/research/Thermal.pdf.
22. Huang L., Liu L.-S. Simultaneous determination of thermal conductivity and thermal diffusivity of food and agricultural materials using a transient plane-source method. J Food Eng 2009, 95:179-185.
23. IEC document 60601-2-37 ed. 2. Medical electrical equipment - Part 2-37: Particular requirements for the basic safety and essential performance of ultrasonic medical diagnostic and monitoring equipment (2007).
24. King R.L., Herman B.A., Maruvada S., Wear K.A., Harris G.R. Development of a HIFU phantom. Sixth International Symposium on Therapeutic Ultrasound 2007, 351-356. American Institute of Physics, Melville, NY. C.-C. Coussios, G. ter Haar (Eds.).
25. King R.L., Lui Y., Maruvada S., Herman B.A., Wear K.A., Harris G.R. Development and characterization of a tissue-mimicking material for high-intensity focused ultrasound. IEEE UFFC 2011, 58:1397-1405.
26. Konofagou E., Thierman J., Hynynen K. The use of ultrasound-stimulated acoustic emission in the monitoring of modules changes with temperature. Ultrasonics 2003, 41:337-345.
27. Kurozawa L.E., El-Aouar A.A., Simões M.R., Axoubel P.M., Murr F.E.X. Determination of thermal conductivity and thermal diffusivity of papaya (Carica papaya L.) as a function of temperature. Braz J Food Technol 2008, 11:78-85.
28. Lafon C., Zderic V., Noble M.L., Yuen J.C., Kaczkowski P.J., Sapozhnikov O.A., Chavrier F., Crum L.A., Vaezy S. Gel phantom for use in high-intensity focused ultrasound dosimetry. Ultrasound Med Biol 2005, 31:1383-1389.
29. Madsen E.L. Ultrasonically soft tissue mimicking material. Medical physics of CT and ultrasound: Tissue imaging and characterization 1980, 531-550. American Institute of Physics, Melville, NY. G.D. Fullerton, J.A. Zagzebski (Eds.).
30. Madsen E.L., Frank G.R., Krouskop T.A., Varghese T., Kallel F., Ophir J. Tissue-Mimicking oil-in-gelatin dispersions for use in heterogeneous elastography phantoms. Ultrason Imaging 2003, 25:17-38.
31. Madsen E.L., Hobson M.A., Shi H., Varghese T., Frank G.R. Tissue-mimicking agar/gelatin materials for use in heterogeneous elastrography phantoms. Phys Med Biol 2005, 50:5597-5618.
32. Madsen E.L., Hobson M.A., Hairong Shi, Varghese T., Frank G.R. Stability of heterogeneous elastography phantoms made from oil dispersions in aqueous gels. Ultrasound Med Biol 2006, 32:261-270.
33. Oliveira J.M., Lessio B.C., Morgante C.M., Santos M.M., Augustor P.E.D. Specific heat (Cp) of tropical fruites: Cajá, cashew apple, cocoa, kiwi, pitanga, soursop fruit and yellow mellon. Int Food Res J 2012, 19:811-814.
34. Park K.S., Guntur S.R., Lee K.I., Dong-Guk P., Choi M.J. Reusable ultrasonic tissue mimicking hydrogels containing nonionic surface-active agents for visualizing thermal lesions. IEEE Trans Biomed Eng 2010, 57:194-202.
35. Pishchalnikov Y.A., Sapozhnikov O.A., Sinilo T.V. Increase in the efficiency of shear wave generation in gelatin due to the nonlinear absorption of a focused ultrasonic beam. Acoust Phys 2002, 48:214-219.
36. Renaud T., Briery P., Andrieu J., Laurent M. Thermal properties of model foods in the frozen state. J Food Eng 1992, 15:83-97.
37. Sehgal C.M., Porter B.R., Greenleaf J.F. Ultrasonic nonlinear parameters and sound speed of alcohol-water mixtures. J Acoust Soc Am 1986, 79:566-569.
38. Sekins K.M. Acoustic neural network thermometry in monitoring of thermal therapies. J Acoust Soc Am 2011, 129:2437. [program abstract].
39. Sekins K.M. High intensity focused ultrasound characterization of deep bleeder acoustic coagulation cuffs. J Acoust Soc Am 2011, 129:2404-2405. [program abstract].
40. Sekins KM, Zeng X, Barnes S, Hopple J, Kook J, Moreau-Gobard R, Hsu S, Ahiekpor-Dravi A, Lee CY, Ramachandara S, Maleke C, Eaton J, Wong K, Keneman S. Acoustic hemostasis device for automated treatment of bleeding in limbs. In: R Muratore, E Konofagou, (eds). Proceedings of the 11th International Symposium on Therapeutic Ultrasound. New York NY: American Institute of Physics; 2011.
41. Zhang M., Castaneda B., Wu Z., Nigwekar P., Joseph J.V., Rubens D.J., Parker K.J. Congruence of imaging estimators and mechanical measurements of viscoelastic properties of soft tissues. Ultrasound Med Biol 2007, 33:1617-1631.