Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation

Cardiovascular Research

Volumn 97, Issue 1, 2013, Pages 106-114

  Saito, Tokuo ^a   Hasegawa, Yutaka ^a   Ishigaki, Yasushi ^a   Yamada, Tetsuya ^a   Gao, Junhong ^a   Imai, Junta ^a   Uno, Kenji ^a   Kaneko, Keizo ^a   Ogihara, Takehide ^a   Shimosawa, Tatsuo ^b   Asano, Tomoichiro ^c   Fujita, Toshiro ^b   Oka, Yoshitomo ^a   Katagiri, Hideki ^a  

^a TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c HIROSHIMA UNIVERSITY   (Japan)

Author keywords

Abdominal aortic aneurysm; Angiotensin II; Atherosclerosis; Inflammation; NF B

Indexed keywords

ANGIOTENSIN II; CELL ADHESION MOLECULE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MATRIX METALLOPROTEINASE;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD PRESSURE MEASUREMENT; CELL ADHESION; CELL HYPERPLASIA; CONTROLLED STUDY; ENDOTHELIUM CELL; GENE EXPRESSION; HISTOPATHOLOGY; HYPERCHOLESTEROLEMIA; IMMUNOHISTOCHEMISTRY; MALE; MOUSE; NEOINTIMA; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; ZYMOGRAPHY;

ANGIOTENSIN II; ANIMALS; AORTA, ABDOMINAL; AORTIC ANEURYSM, ABDOMINAL; APOLIPOPROTEINS E; BIOLOGICAL MARKERS; DISEASE MODELS, ANIMAL; ENDOTHELIUM, VASCULAR; FEMORAL ARTERY; HUMANS; HYPERPLASIA; I-KAPPA B PROTEINS; INFLAMMATION MEDIATORS; MALE; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; NF-KAPPA B; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; VASCULAR SYSTEM INJURIES;

EID: 84871763644     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvs298     Document Type: Article

References (33)

1. Aird WC. Phenotypic heterogeneity of the endothelium. I. Structure, function, and mechanisms. Circ Res 2007;100:158-173. (Pubitemid 46208717)
2. Aird WC. Phenotypic heterogeneity of the endothelium. II. Representative vascular beds. Circ Res 2007;100:174-190. (Pubitemid 46208718)
3. Kim JA, Montagnani M, Koh KK, Quon MJ. Reciprocal relationships between insulin resistance and endothelial dysfunction: molecular and pathophysiological mechanisms. Circulation 2006;113:1888-1904. (Pubitemid 43739401)
4. Kockx MM, De Meyer GR, Jacob WA, Bult H, Herman AG. Triphasic sequence of neointimal formation in the cuffed carotid artery of the rabbit. Arterioscler Thromb 1992;12:1447-1457.
5. Golledge J, Muller J, Daugherty A, Norman P. Abdominal aortic aneurysm: pathogen-esis and implications for management. Arterioscler Thromb Vasc Biol 2006; 26:2605-2613.
6. Shimizu K, Mitchell RN, Libby P. Inflammation and cellular immune responses in abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2006;26:987-994. (Pubitemid 43732102)
7. Rocha VZ, Libby P. Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol 2009; 6:399-409.
8. Gao J, Ishigaki Y, Yamada T, Kondo K, Yamaguchi S, Imai J et al. Involvement of endo-plasmic stress protein C/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses. Circulation 2011;124:830-839.
9. Daugherty A, Manning MW, Cassis LA. Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 2000; 105:1605-1612. (Pubitemid 30390311)
10. Longo GM, Xiong W, Greiner TC, Zhao Y, Fiotti N, Baxter BT. Matrix metallopro-teinases 2 and 9 work in concert to produce aortic aneurysms. J Clin Invest 2002; 110:625-632. (Pubitemid 34988786)
11. Hayden MS, Ghosh S. Shared principles in NF-kappaB signaling. Cell 2008; 132:344-362.
12. Hasegawa Y, Ogihara T, Yamada T, Ishigaki Y, Imai J, Uno K et al. Bone marrow (BM) transplantation promotes beta-cell regeneration after acute injury through BM cell mobilization. Endocrinology 2007;148:2006-2015. (Pubitemid 46997048)
13. Henke N, Schmidt-Ullrich R, Dechend R, Park JK, Qadri F, Wellner M et al. Vascular endothelial cell-specific NF-kappaB suppression attenuates hypertension-induced renal damage. Circ Res 2007;101:268-276. (Pubitemid 47344076)
14. Gareus R, Kotsaki E, Xanthoulea S, van der Made I, Gijbels MJ, Kardakaris R et al. Endothelial cell-specific NF-kappaB inhibition protects mice from atherosclerosis. Cell Metab 2008;8:372-383.
15. Ye X, Ding J, Zhou X, Chen G, Liu SF. Divergent roles of endothelial NF-kappaB in multiple organ injury and bacterial clearance in mouse models of sepsis. J Exp Med 2008;205:1303-1315. (Pubitemid 351831488)
16. Ding J, Song D, Ye X, Liu SF. A pivotal role of endothelial-specific NF-{kappa}B signaling in the pathogenesis of septic shock and septic vascular dysfunction. J Immunol 2009;183:4031-4038.
17. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 1992;258:468-471.
18. Ishigaki Y, Katagiri H, Gao J, Yamada T, Imai J, Uno K et al. Impact of plasma oxidized low-density lipoprotein removal on atherosclerosis. Circulation 2008;118:75-83.
19. Ishigaki Y, Katagiri H, Yamada T, Ogihara T, Imai J, Uno K et al. Dissipating excess energy stored in the liver is a potential treatment strategy for diabetes associated with obesity. Diabetes 2005;54:322-332.
20. Gao J, Katagiri H, Ishigaki Y, Yamada T, Ogihara T, Imai J et al. Involvement of apoli-poprotein E in excess fat accumulation and insulin resistance. Diabetes 2007; 56:24-33.
21. Libby P. Inflammation in atherosclerosis. Nature 2002;420:868-874. (Pubitemid 36019640)
22. Egashira K, Zhao Q, Kataoka C, Ohtani K, Usui M, Charo IF et al. Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periar-terial injury in mice and monkeys. Circ Res 2002;90:1167-1172. (Pubitemid 34786901)
23. Hellenthal FA, Buurman WA, Wodzig WK, Schurink GW. Biomarkers of AAA progression. Part 1: extracellular matrix degeneration. Nat Rev Cardiol 2009;6:464-474.
24. De Palma M, Venneri MA, Roca C, Naldini L. Targeting exogenous genes to tumor angiogenesis by transplantation of genetically modified hematopoietic stem cells. Nat Med 2003;9:789-795. (Pubitemid 36749231)
25. Maiellaro K, Taylor WR. The role of the adventitia in vascular inflammation. Cardiovasc Res 2007;75:640-648. (Pubitemid 47238746)
26. Henderson EL, Geng YJ, Sukhova GK, Whittemore AD, Knox J, Libby P. Death of smooth muscle cells and expression of mediators of apoptosis by T lymphocytes in human abdominal aortic aneurysms. Circulation 1999;99:96-104. (Pubitemid 29035963)
27. McCormick ML, Gavrila D, Weintraub NL. Role of oxidative stress in the pathogen-esis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2007;27:461-469.
28. Hannawa KK, Cho BS, Sinha I, Roelofs KJ, Myers DD, Wakefield TJ et al. Attenuation of experimental aortic aneurysm formation in P-selectin knockout mice. Ann NY Acad Sci 2006;1085:353-359. (Pubitemid 47091986)
29. Ishibashi M, Egashira K, Zhao Q, Hiasa K, Ohtani K, Ihara Y et al. Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholester-olemic mice. Arterioscler Thromb Vasc Biol 2004;24:e174-e178.
30. Tham DM, Martin-McNulty B, Wang YX, Wilson DW, Vergona R, Sullivan ME et al. Angiotensin II is associated with activation of NF-kappaB-mediated genes and down-regulation of PPARs. Physiol Genomics 2002;11:21-30.
31. Higuchi S, Ohtsu H, Suzuki H, Shirai H, Frank GD, Eguchi S. Angiotensin II signal trans-duction through the AT1 receptor: novel insights into mechanisms and pathophysi-ology. Clin Sci 2007;112:417-428. (Pubitemid 46587457)
32. van der Vliet JA, Boll AP. Abdominal aortic aneurysm. Lancet 1997;349:863-866. (Pubitemid 27129225)
33. Cassis LA, Gupte M, Thayer S, Zhang X, Charnigo R, Howatt DA et al. ANG II infusion promotes abdominal aortic aneurysms independent of increased blood pressure in hypercholesterolemic mice. Am J Physiol Heart Circ Physiol 2009;296:1660-1665.