Antioxidant and antihepatotoxic efficacy of methanolic extract of Elephantopus scaber Linn in Wistar rats

Asian Pacific Journal of Tropical Disease

Volumn 2, Issue SUPPL2, 2012, Pages

  Sheeba, Kannakuzhiyil Oommen ^a   Wills, Pallara Janardhanan ^a   Latha, Bhaskara Kurup ^a   Rajalekshmy, Rajagopal ^a   Latha, Mukalel Sankunni ^a  

^a MAHATMA GANDHI UNIVERSITY   (India)

Author keywords

Antihepatotoxic activity; Antioxidant activity; Elephantopus scaber

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ANTIOXIDANT; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CATALASE; CURCUMIN; ELEPHANTOPUS SCABER EXTRACT; FERROUS ASCORBATE; GAMMA GLUTAMYLTRANSFERASE; GLUTATHIONE; HYDROXYL GROUP; METHANOL; PLANT EXTRACT; SUPEROXIDE; SUPEROXIDE DISMUTASE; THIOBARBITURIC ACID REACTIVE SUBSTANCE; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; ELEPHANTOPUS SCABER; GAMMA GLUTAMYL TRANSFERASE BLOOD LEVEL; HISTOPATHOLOGY; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; LIVER INJURY; LIVER PROTECTION; LIVER TOXICITY; MALE; NONHUMAN; PLANT ROOT; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT;

EID: 84871754012     PISSN: 22221808     EISSN: None     Source Type: Journal    
DOI: 10.1016/S2222-1808(12)60289-8     Document Type: Article

References (18)

1. Knockaert L, Berson A, Ribault C, Prost PE, Fautrel A, Pajaud J, et al. Carbon tetrachloride-mediated lipid peroxidation induces early mitochondrial alterations in mouse liver. Lab Invest 2012, 92(3):396-410.
2. Kumar BS, Chung BC, Kwon OS, Jung BH Discovery of common urinary biomarkers for hepatotoxicity induced by carbon tetrachloride, acetaminophenand methotrexate by mass spectrometry-based metabolomics. J Appl Toxicol 2012, 32(7):505-520.
3. Girish C, Koner BC, et al. Hepatoprotective activity of six polyherbal formulations in paracetamol induced liver toxicity in mice. Indian J Med Res 2009, 129:569-578.
4. Simon RP, Patel HV, Kiran K Hepatoprotective activity of some plants extract against paracetamol induced hepatotoxicity in rats. J Herbal Med Toxicol 2010, 4(2):101-106.
5. Merlin NJ, Parthasarathy V Antioxidant and hepatoprotective activity of chloroform and ethanol extracts of Gmelina asiatica aerial parts. J Medicinal Plants Research 2011, 5(4):533-538.
6. Hammer Johns Tapping an Amazonian plethora: four medicinal plants of Marajo island, Para (Brazil). J Ethnopharmacol 1993, 40:53-75.
7. Lin CC, et al. The evaluation of hepatoprotective effects of Taiwan Folk medicine Teng-khia-U. J Ethnopharmacol 1985, 45:113-123.
8. Tsai CC, Linn CC Antiinflammatory effects of Taiwan folk medicine. Teng-Khia-U on carageenan and adjuvant-induced paw edema in rats. J Ethnopharmacol 1999, 64:85-89.
9. 4-induced liver injury. Indian J Physiol Pharmacol 2001, 45(4):481-486.
10. 4 induced hepatotoxicity in rats. Indian J Exp Biol 2008, 46:52.
11. Gini CK, Muraleedhara Kurup G Antioxidant and hepatoprotective activity of phanizomenon flos-aquae Linn against paracetamol intoxication in rats. Indian J Exp Biol 2010, 48:11-23.
12. Roome T, Dar A, Ali S, Naqvi S Choudhary MI. A study on antioxidant, free radical scavenging, anti-inflammatory and hepatoprotective actions of Aegiceras corniculatum (stem) extracts. J Ethnopharmacol 2008, 118(3):514-521.
13. Asha VV, Sheeba MS, Suresh V, Wills PJ Hepatoprotection of Phyllanthus maderaspatensis against experimentally induced liver injury in rats. Fitoterapia 2007, 78(2):134-141.
14. Shah VN, Shah MB, Bhatt PA In vivo and In vitro Antioxidant and Hepatoprotective effects of Classical ayurvedic formulation Punarnavashtak kwath against Ethanol induced hepatotoxicity. Pharmacognosy J 2010, 2(16):38-47.
15. Lefkowitch JH Pathologic diagnosis of liver disease. Hepatology-A Textbook of Liver Disease 1996, 844-871. W.B. Saunders Company, Philadelphia. D. Zakim, T.D. Boyer (Eds.).
16. Koleckár V, Brojerová E, Opletal L, Jun D, Kuca K Antioxidants, freeradicals, mechanism of action and application in the therapy of the sulfur mustard caused injury. Ceska Slov Farm 2007, 56(2):73-76.
17. Anson P, Pierce Eric de Waal, McManus Linda M., et al. Oxidation and structural perturbation of redox-sensitive enzymes in injured skeletal muscle, ree. Radical Biol Med 2007, 43(12):1584-1593.
18. DeSilva, et al. A New Sesquiterpene Lactone From E. scaber. Phytochemistry 1982, 25(5):1173-1982.