Silencing of human DNA polymerase λ causes replication stress and is synthetically lethal with an impaired S phase checkpoint

Nucleic Acids Research

Volumn 41, Issue 1, 2013, Pages 229-241

  Zucca, Elisa ^a   Bertoletti, Federica ^a   Wimmer, Ursula ^b   Ferrari, Elena ^b   Mazzini, Giuliano ^a   Khoronenkova, Svetlana ^c   Grosse, Nicole ^b   Van Loon, Barbara ^b   Dianov, Grigory ^c   Hübscher, Ulrich ^b   Maga, Giovanni ^a  

^a CNR   (Italy)

^b UNIVERSITY OF ZURICH   (Switzerland)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ATR PROTEIN; CHECKPOINT KINASE 1; DNA DIRECTED DNA POLYMERASE ALPHA;

ARTICLE; CANCER CELL CULTURE; CELL CYCLE PROGRESSION; CELL DEATH; CELL DIFFERENTIATION; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; DNA DAMAGE; DNA REPLICATION; ENZYME ACTIVATION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; OXIDATIVE STRESS; PRIORITY JOURNAL; REPLICATION FORK STRESS; S PHASE CELL CYCLE CHECKPOINT;

CELL LINE, TUMOR; CELL SURVIVAL; DNA DAMAGE; DNA POLYMERASE BETA; DNA REPLICATION; HELA CELLS; HUMANS; HYDROXYUREA; OXIDATIVE STRESS; PROTEIN KINASES; RECOMBINATIONAL DNA REPAIR; RNA INTERFERENCE; S PHASE CELL CYCLE CHECKPOINTS; STRESS, PHYSIOLOGICAL;

EID: 84871735473     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gks1016     Document Type: Article

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