Control of DNA polymerase λ stability by phosphorylation and ubiquitination during the cell cycle

EMBO Reports

Volumn 9, Issue 10, 2008, Pages 1027-1033

  Wimmer, Ursula ^a   Ferrari, Elena ^a   Hunziker, Peter ^b   Hübscher, Ulrich ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b FUNCTIONAL GENOMICS CENTER ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN A; DNA DIRECTED DNA POLYMERASE; DNA DIRECTED DNA POLYMERASE LAMBDA; THREONINE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CYCLE G2 PHASE; CELL CYCLE PROGRESSION; CELL CYCLE REGULATION; CELL CYCLE S PHASE; CONTROLLED STUDY; EMBRYO; ENZYME REGULATION; ENZYME STABILITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; UBIQUITINATION;

ANIMALS; CELL CYCLE; CELL LINE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; DNA POLYMERASE BETA; ENZYME STABILITY; G2 PHASE; HUMANS; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; S PHASE; UBIQUITIN; UBIQUITINATION;

EID: 53249097348     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/embor.2008.148     Document Type: Article

References (26)

1. Bertocci B, De Smet A, Flatter E, Dahan A, Bories JC, Landreau C, Weill JC, Reynaud CA (2002) Cutting edge: DNA polymerases μ and λ are dispensable for Ig gene hypermutation. J Immunol 168: 3702-3706
2. Bertocci B, De Smet A, Weill JC, Reynaud CA (2006) Nonoverlapping functions of DNA polymerases μ, λ, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo. Immunity 25: 31-41
3. Braithwaite EK et al (2005a) DNA polymerase λ protects mouse fibroblasts against oxidative DNA damage and is recruited to sites of DNA damage/repair. J Biol Chem 280: 31641-31647
4. Braithwaite EK, Prasad R, Shock DD, Hou EW, Beard WA, Wilson SH (2005b) DNA polymerase λ mediates a back-up base excision repair activity in extracts of mouse embryonic fibroblasts. J Biol Chem 280: 18469-18475
5. Elsasser S, Finley D (2005) Delivery of ubiquitinated substrates to protein-unfolding machines. Nat Cell Biol 7: 742-749
6. El-Shemerly M, Janscak P, Hess D, Jiricny J, Ferrari S (2005) Degradation of human exonuclease 1b upon DNA synthesis inhibition. Cancer Res 65: 3604-3609
7. Fan W, Wu X (2004) DNA polymerase λ can elongate on DNA substrates mimicking non-homologous end joining and interact with XRCC4-ligase IV complex. Biochem Biophys Res Commun 323: 1328-1333
8. Frouin I, Toueille M, Ferrari E, Shevelev I, Hübscher U (2005) Phosphorylation of human DNA polymerase λ by the cyclin-dependent kinase Cdk2/cyclin A complex is modulated by its association with proliferating cell nuclear antigen. Nucleic Acids Res 33: 5354-5361
9. Garcia-Diaz M, Bebenek K, Kunkel TA, Blanco L (2001) Identification of an intrinsic 5′-deoxyribose-5-phosphate lyase activity in human DNA polymerase λ: A possible role in base excision repair. J Biol Chem 276: 34659-34663
10. Garcia-Diaz M, Bebenek K, Krahn JM, Blanco L, Kunkel TA, Pedersen LC (2004) A structural solution for the DNA polymerase λ-dependent repair of DNA gaps with minimal homology. Mol Cell 13: 561-572
11. Garcia-Diaz M, Bebenek K, Krahn JM, Kunkel TA, Pedersen LC (2005) A closed conformation for the Pol λ catalytic cycle. Nat Struct Mol Biol 12: 97-98
12. Goldberg AL (2003) Protein degradation and protection against misfolded or damaged proteins. Nature 426: 895-899
13. Kobayashi Y et al (2002) Hydrocephalus, situs inversus, chronic sinusitis, and male infertility in DNA polymerase λ-deficient mice: possible implication for the pathogenesis of immotile cilia syndrome. Mol Cell Biol 22: 2769-2776
14. Lee JW, Blanco L, Zhou T, Garcia-Diaz M, Bebenek K, Kunkel TA, Wang Z, Povirk LF (2004) Implication of DNA polymerase λ in alignment-based gap filling for nonhomologous DNA end joining in human nuclear extracts. J Biol Chem 279: 805-811
15. Maga G, Villani G, Ramadan K, Shevelev I, Tanguy Le Gac N, Blanco L, Blanca G, Spadari S, Hübscher U (2002) Human DNA polymerase λ functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis. J Biol Chem 277: 48434-48440
16. Maga G, Villani G, Crespan E, Wimmer U, Ferrari E, Bertocci B, Hübscher U (2007) 8-Oxo-guanine bypass by human DNA polymerases in the presence of auxiliary proteins. Nature 447: 606-608
17. Malumbres M, Barbacid M (2005) Mammalian cyclin-dependent kinases. Trends Biochem Sci 30: 630-641
18. Nick McElhinny SA, Havener JM, Garcia-Diaz M, Juarez R, Bebenek K, Kee BL, Blanco L, Kunkel TA, Ramsden DA (2005) A gradient of template dependence defines distinct biological roles for family X polymerases in nonhomologous end joining. Mol Cell 19: 357-366
19. Parsons JL, Tait PS, Finch D, Dianova II, Allinson SL, Dianov GL (2008) CHIP-mediated degradation and DNA damage-dependent stabilization regulate base excision repair proteins. Mol Cell 29: 477-487
20. Picher AJ, Blanco L (2007) Human DNA polymerase λ is a proficient extender of primer ends paired to 7,8-dihydro-8-oxoguanine. DNA Repair 6: 1749-1756
21. Pickart CM (2004) Back to the future with ubiquitin. Cell 116 181-190
22. Ramadan K, Shevelev I, Hübscher U (2004) The DNA-polymerase-X family: controllers of DNA quality? Nat Rev Mol Cell Biol 5: 1038-1043
23. Rasband WS (1997-2007) ImageJ. Bethesda, Maryland, USA: National Institutes of Health http://rsb.info.nih.gov/ij/
24. Sobol RW (2008) CHIPping away at base excision repair. Mol Cell 29: 413-415
25. Solan JL, Fry MD, TenBroek EM, Lampe PD (2003) Connexin43 phosphorylation at S368 is acute during S and G2/M and in response to protein kinase C activation. J Cell Sci 116: 2203-2211
26. Yu CT, Hsu JM, Lee YC, Tsou AP, Chou CK, Huang CY (2005) Phosphorylation and stabilization of HURP by Aurora-A: Implication of HURP as a transforming target of Aurora-A. Mol Cell Biol 25: 5789-5800