Tear proteome and protein network analyses reveal a novel pentamarker panel for tear film characterization in dry eye and meibomian gland dysfunction

Journal of Proteomics

Volumn 78, Issue , 2013, Pages 94-112

  Soria, J ^a   Duran J A ^b,c   Etxebarria, J ^d   Merayo, J ^e   Gonzalez N ^a   Reigada, R ^a   Garcia I ^a   Acera, A ^a   Suarez T ^a  

^a Bioftalmik Applied Research   (Spain)

^b Instituto Clinico Quirurgico De Oftalmologia Icqo   (Spain)

^c UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^d HOSPITAL DE CRUCES   (Spain)

^e Fernandez Vega Eye Institute   (Spain)

Author keywords

Biomarkers; Dry eye; Meibomian gland dysfunction; Network analysis; Proteomics; Tears

Indexed keywords

ACTIN CYTOPLASMIC 1; ANNEXIN A11; CALCYCLIN; CALGRANULIN A; CALGRANULIN B; CALVASCULIN; CYSTATIN S; CYSTATIN SN; GALECTIN 7; GLUTATHIONE TRANSFERASE P1; LACTOFERRIN; LIPOCALIN 1; LIPOCORTIN 1; MAMMAGLOBIN B; PHOSPHOLIPASE A2 ACTIVATING PROTEIN; PROLACTIN INDUCIBLE PROTEIN; PROTEIN; UNCLASSIFIED DRUG; ZINC ALPHA 2 GLYCOPROTEIN;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; COMPARATIVE STUDY; CONTROLLED STUDY; DRY EYE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; MEIBOMIAN GLAND; NUCLEOTIDE SEQUENCE; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN INTERACTION; PROTEOMICS; SEBACEOUS GLAND DISEASE; SENSITIVITY AND SPECIFICITY; TEAR FILM; TWO DIMENSIONAL GEL ELECTROPHORESIS;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; DRY EYE SYNDROMES; EYE PROTEINS; FEMALE; HUMANS; MALE; MEIBOMIAN GLANDS; MIDDLE AGED; PROSPECTIVE STUDIES; PROTEOME; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TEARS;

MEIBOMIA;

EID: 84871732703     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.11.017     Document Type: Article

References (43)

1. The definition and classification of dry eye disease: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf 2007, 5:75-92.
2. Nelson J.D., Shimazaki J., Benitez-del-Castillo J.M., Craig J.P., McCulley J.P., Den S., et al. The international workshop on meibomian gland dysfunction: report of the definition and classification subcommittee. Invest Ophthalmol Vis Sci 2011, 52:1930-1937.
3. Lemp M.A., Nichols K.K. Blepharitis in the United States 2009: a survey-based perspective on prevalence and treatment. Ocul Surf 2009, 7:S1-S14.
4. Craig J.P., Tomlinson A. Importance of the lipid layer in human tear film stability and evaporation. Optom Vis Sci 1997, 74:8-13.
5. Jackson W.B. Blepharitis: current strategies for diagnosis and management. Can J Ophthalmol 2008, 43:170-179.
6. Nichols K.K., Nichols J.J., Mitchell G.L. The lack of association between signs and symptoms in patients with dry eye disease. Cornea 2004, 23:762-770.
7. Grus F.H., Sabuncuo P., Augustin A.J. Analysis of tear protein patterns of dry-eye patients using fluorescent staining dyes and two-dimensional quantification algorithms. Electrophoresis 2001, 22:1845-1850.
8. Koo B.-S., Lee D.-Y., Ha H.-S., Kim J.-C., Kim C.-W. Comparative analysis of the tear protein expression in blepharitis patients using two-dimensional electrophoresis. J Proteome Res 2005, 4:719-724.
9. Acera A., Suárez T., Rodríguez-Agirretxe I., Vecino E., Durán J.A. Changes in tear protein profile in patients with conjunctivochalasis. Cornea 2011, 30:42-49.
10. Versura P., Nanni P., Bavelloni A., Blalock W.L., Piazzi M., Roda A., et al. Tear proteomics in evaporative dry eye disease. Eye 2010, 24:1396-1402.
11. de Souza G.A., Godoy L.M.F., Mann M. Identification of 491 proteins in the tear fluid proteome reveals a large number of proteases and protease inhibitors. Genome Biol 2006, 7:R72.
12. Green-Church K.B., Nichols K.K., Kleinholz N.M., Zhang L., Nichols J.J. Investigation of the human tear film proteome using multiple proteomic approaches. Mol Vis 2008, 14:456-470.
13. Nichols J.J., Green-Church K.B. Mass spectrometry-based proteomic analyses in contact lens-related dry eye. Cornea 2009, 28:1109-1117.
14. Cappadona S., Nanni P., Benevento M., Levander F., Versura P., Roda A., et al. Improved label-free LC-MS analysis by wavelet-based noise rejection. J Biomed Biotechnol 2010, 2010:131505.
15. Zhou L., Beuerman R.W., Chan C.M., Zhao S.Z., Li X.R., Yang H., et al. Identification of tear fluid biomarkers in dry eye syndrome using iTRAQ quantitative proteomics. J Proteome Res 2009, 8:4889-4905.
16. Grus F.H., Podust V.N., Bruns K., Lackner K., Fu S., Dalmasso E.A., et al. SELDI-TOF-MS ProteinChip array profiling of tears from patients with dry eye. Invest Ophthalmol Vis Sci 2005, 46:863-876.
17. Zhou L., Zhao S.Z., Koh S.K., Chen L., Vaz C., Tanavde V., et al. In-depth analysis of the human tear proteome. J Proteomics 2012, 75:3877-3885.
18. López-Cisternas J., Castillo-Díaz J., Traipe-Castro L., López-Solís R.O. Use of polyurethane minisponges to collect human tear fluid. Cornea 2006, 25:312-318.
19. Tusher V.G., Tibshirani R., Chu G. Significance analysis of microarrays applied to the ionizing radiation response. PNAS 2001, 98:5116-5121.
20. Shevchenko A., Tomas H., Havlis J., Olsen J.V., Mann M. In-gel digestion for mass spectrometric characterization of proteins and proteomes. Nat Protoc 2006, 1:2856-2860.
21. Obayashi T., Kinoshita K. COXPRESdb: a database to compare gene coexpression in seven model animals. Nucleic Acids Res 2011, 39:D1016-D1022.
22. Riau A.K., Wong T.T., Beuerman R.W., Tong L. Calcium-binding S100 protein expression in pterygium. Mol Vis 2009, 15:335-342.
23. Heizmann C.W., Fritz G., Schäfer B.W. S100 proteins: structure, functions and pathology. Front Biosci 2002, 7:d1356-d1368.
24. McKiernan E., McDermott E.W., Evoy D., Crown J., Duffy M.J. The role of S100 genes in breast cancer progression. Tumour Biol 2010, 32(3).
25. Lim L.H.K., Pervaiz S. Annexin 1: the new face of an old molecule. FASEB J 2007, 21:968-975.
26. da Silva P.S., Girol A.P., Oliani S.M. Mast cells modulate the inflammatory process in endotoxin-induced uveitis. Mol Vis 2011, 17:1310-1319.
27. Tsai P.S., Evans J.E., Green K.M., Sullivan R.M., Schaumberg D.A., Richards S.M., et al. Proteomic analysis of human meibomian gland secretions. Br J Opthalmol 2006, 90:372-377.
28. Liu S., Richards S.M., Lo K., Hatton M., Fay A., Sullivan D.A. Changes in gene expression in human meibomian gland dysfunction. Invest Ophthalmol Vis Sci 2011, 52:2727-2740.
29. Dartt D.A. Tear lipocalin: structure and function. Ocul Surf 2011, 9:126-138.
30. Bron A.J., Tiffany J.M., Gouveia S.M., Yokoi N., Voon L.W. Functional aspects of the tear film lipid layer. Exp Eye Res 2004, 78:347-360.
31. Tseng S.C. Staging of conjunctival squamous metaplasia by impression cytology. Ophthalmology 1985, 92:728-733.
32. Dezso Z., Oltvai Z.N., Barabási A.-L. Bioinformatics analysis of experimentally determined protein complexes in the yeast Saccharomyces cerevisiae. Genome Res 2003, 13:2450-2454.
33. Towne J.E., Krane C.M., Bachurski C.J., Menon A.G. Tumor necrosis factor-alpha inhibits aquaporin 5 expression in mouse lung epithelial cells. J Biol Chem 2001, 276:18657-18664.
34. Chen Z., Wang X., Gao L., Bai L., Zhu R., Bai C. Regulation of MUC5AC mucin secretion by depletion of AQP5 in SPC-A1 cells. Biochem Biophys Res Commun 2006, 342:775-781.
35. Zhang F., Sha J., Wood T.G., Galindo C.L., Garner H.R., Burkart M.F., et al. Alteration in the activation state of new inflammation-associated targets by phospholipase A2-activating protein (PLAA). Cell Signal 2008, 20:844-861.
36. Ranganathan A.C., Nelson K.K., Rodriguez A.M., Kim K.H., Tower G.B., Rutter J.L., et al. Manganese superoxide dismutase signals matrix metalloproteinase expression via H2O2-dependent ERK1/2 activation. J Biol Chem 2001, 276:14264-14270.
37. Sun H.-N., Kim S.-U., Huang S.M., Kim J.-M., Park Y.-H., Kim S.-H., et al. Microglial peroxiredoxin V acts as an inducible anti-inflammatory antioxidant through cooperation with redox signaling cascades. J Neurochem 2010, 114:39-50.
38. Voisin S.N., Krakovska O., Matta A., Desouza L.V., Romaschin A.D., Colgan T.J., et al. Identification of novel molecular targets for endometrial cancer using a drill-down LC-MS/MS approach with iTRAQ. PLoS One 2011, 6:e16352.
39. Lo H.-W., Antoun G.R., Ali-Osman F. The human glutathione S-transferase P1 protein is phosphorylated and its metabolic function enhanced by the Ser/Thr protein kinases, cAMP-dependent protein kinase and protein kinase C, in glioblastoma cells. Cancer Res 2004, 64:9131-9138.
40. Lefranc F., Decaestecker C., Brotchi J., Heizmann C.W., Dewitte O., Kiss R., et al. Co-expression/co-location of S100 proteins (S100B, S100A1 and S100A2) and protein kinase C (PKC-beta, -eta and -zeta) in a rat model of cerebral basilar artery vasospasm. Neuropathol Appl Neurobiol 2005, 31:649-660.
41. Zoukhri D., Macari E., Choi S.H., Kublin C.L. c-Jun NH2-terminal kinase mediates interleukin-1beta-induced inhibition of lacrimal gland secretion. J Neurochem 2006, 96:126-135.
42. Chen Z., Tong L., Li Z., Yoon K.-C., Qi H., Farley W., et al. Hyperosmolarity-induced cornification of human corneal epithelial cells is regulated by JNK MAPK. Invest Ophthalmol Vis Sci 2008, 49:539-549.
43. Tong L., Zhou L., Beuerman R.W., Zhao S.Z., Li X.R. Association of tear proteins with Meibomian gland disease and dry eye symptoms. Br J Opthalmol 2011, 95:848-852.