Immunohistochemical expression and distribution of orexin, orphanin and leptin in the major salivary glands of some mammals

Folia Histochemica et Cytobiologica

Volumn 50, Issue 4, 2012, Pages 504-512

  Leone, Angelo ^a   Spatola, Giovanni Francesco ^a   Cucco, Daniela ^a   Tessitore, Vincenzo ^a   Bonaventura, Giuseppe ^a   Uzzo, Maria Laura ^a  

^a UNIVERSITY OF PALERMO   (Italy)

Author keywords

Cow; IHC; Leptin; Major salivary glands; Nociception; Orexin; Orphanin FQ; Rat; Sheep

Indexed keywords

LEPTIN; NOCICEPTIN; OREXIN A;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COW; ENERGY METABOLISM; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PARENCHYMA; PAROTID GLAND; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEIN SYNTHESIS; RAT; SALIVARY GLAND FUNCTION; SHEEP; SUBLINGUAL GLAND; SUBMANDIBULAR GLAND;

MAMMALIA; OVIS ARIES; RATTUS;

EID: 84871726175     PISSN: 02398508     EISSN: 18975631     Source Type: Journal    
DOI: 10.5603/FHC.2012.0071     Document Type: Article

References (51)

1. Luo W, Latchney LR, Culp DJ. G protein coupling to M1 and M3 receptors in sublingual glands. Am J Physiol Cell Physiol. 2001;280:884-896.
2. Bredt DS, Snyder SH, Nitric oxyde, a novel neuronal messenger. Neuron. 1992;8:3.
3. Lohinai Z, Szekely AD, Soos L, Feher E. Distribution of nitric oxide synthase containing elements in the feline submandibular gland. Neurosci Lett. 1995;192:9-12.
4. Soinila S, Vanhatalo S, Lumme A, Back N, Soinila J. Nitric oxide synthase in the autonomic and sensory ganglia innervating the submandibular salivary gland. Microsc Res Techn 1996;35:32-43.
5. Lomniczi A, Suburo AM, Elverdin JC et al. Role of nitric oxide in salivary secretion. Neuroimmunomodulation. 1998;5:226-233.
6. Takai N, Uchihashi K, Higuchi K, Yoshida Y, Yamaguchi M. Localization of neuronal-costitutive nitric oxide synthase and secretory regulation by nitric oxide in the rat submandibular and sublingual glands. Arch Oral Biol. 1999;44:745-750.
7. Looms D, Tritsaris K, Pedersen AM, Nauntofte B, Dissing S. Nitric oxide signalling in salivary glands. J. Oral Pathol Med. 2002;31:569-584.
8. Egea JC, Hirtz C, Gross R et al. Preproinsulin I and II mRNA expression in adult rat submandibular glands. Eur J Oral Sci. 2000;108:292-296.
9. Perez-Castillo A, Blazquez E. Synthesis and release of glucagon by human glands. Diabetologia. 1980;19:123-129.
10. De Matteis R, Puxeddu R, Riva A, Cinti S. Intralobular ducts of human major salivary glands contain leptin and its receptor. J Anat. 2002;201:363-370.
11. Aydin S, Halifeoglu I, Ozercan IH et al. A comparison of leptin and gherlin levels in plasma and saliva of young healthy subjects. Peptides. 2005;26:647-652.
12. Di Marzo V, Matias I. Endocannabinoid control of food intake and energy balance. Nat Neurosci. 2005;8:85-89.
13. Cota D, Woods SC. The role of the endocannabinoid system in the regulation of energy homeostasis. Curr Opin Endocrin Diab. 2005;12,338-351.
14. De Lecea L, Kilduff TS, Peyron C et al. The hypocretins: hipotalamus-specific peptides with neuroexcitatory activity. Proc Natl Acad Sci USA; 1998;95:322-327.
15. Peyron C, Tighe DK, Van den Pol AN et al. Neurons containing hypocretin (orexin) project to multiple neuronal systems. J Neurosci, 1998;18:9996-10015.
16. Neal CR Jr, Mansour A, Reinscheid R, Nothacker HP, Civelli O, Watson SJ Jr. Localization of orphanin FQ (nociceptin) peptide and messenger RNA in the central nervous system of the rat. J Comp Neurol. 19;1999;406:503-547.
17. Meunier JC, Mollereau C, Toll L et al. Isolation and structure of the endogenous agonist of opioid receptor-like ORL1 receptor. Nature. 1995;377:532-535.
18. Sakurai T, Amemiya A, Ishii M et al. Orexin and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998;92:573-585.
19. Annette L, Kirchgessner AL. Orexins in the Brain-Gut Axis. Endocrine Rev. 2002;23:1-15.
20. Adeghate E, Hameed RS. Immunolocalization of orexin-1 receptor in the pancreas of normal and diabetic rats. Biogenic Amines. 2005;19:347-355.
21. Dall'Aglio C, Pascucci L, Mercati F, Giontella A, Pedini V, Ceccarelli P. Immunohistochemical identification and localization of orexin A and orexin type2 receptor in the cow gastrointestinal tract. Res Vet Sci. 2009;86:189-193.
22. Adeghate E, Fernandez-Cabezudo M, Hameed R et al. Orexin1 Receptor colocalizes with pancreatic hormones in islet cells and modulates the outcome of streptozotocin-induced diabetes mellitus. PloS One. 2010;5:8587.
23. Cinti S, Frederic RC, Zingaretti MC, De Matteis R, Flier JS, Lowell BB. Immunohistochemical localization of leptin and uncoupling protein in white and brown adipose tissue. Endocrinology. 1997;138,797-804.
24. Bado A, Lavasseur S, Attoub S et al. The stomach is a source of leptin. Nature. 1998;394:790-793.
25. Cinti S, De Matteis R, Pico C et al. Secretory granules of endocrine and chief cells of human stomach mucosa contain leptin. Int J Obes. 2000;24:789-793.
26. Karteris E, Chen J, Randeva HS. Expression of human prepro-orexin and signaling characteristics of orexin receptors in the male reproductive system. J Clin Endocrinol Metab. 2004;89:1957-1962.
27. Pavone LM, Tafuri S, Avallone L, Staiano N, Vittoria A, Expression of orexin A and its receptor 1 in the vestibular glands of the cow genital tract. Anat Rec. 2009;292:202-206.
28. Randeva HS, Karteris E, Grammatopoulos D, Hillhouse EW. Expression of orexin A and the functional orexin type2 receptors in the human adult adrenals: implications for adrenal function and energy homeostasis. J Clin Endocrinol Metab. 2001;86:4808-4813.
29. Barreiro ML, Pineda R, Gaytan F et al. Pattern of orexin expression and direct biological actions of orexin-A in rat testis. Endocrinology. 2005;146:5164-5175.
30. Walker RA. Quantification of immunohistochemistry-issues concerning methods, utility and semiquantitative assessment I. Histopathology. 2006;49:406-410.
31. Taylor CR, Levenson RM. Quantification of immunohistochemistry-issues concerning methods, utility and semiquantitative assessment II. Histopathology. 2006;49:411-424.
32. Lehr HA, Mankoff DA, Corwin D, Santeusanio G, Gown AM. Application of photoshop-based image analysis to quantification of hormone receptor expression in breast cancer. J Histochem Cytochem. 1997;45:1559-1565.
33. Kirkeby S, Thomsen CE. Quantitative immunohistochemistry of fluorescence labelled probes using low-cost software. J Immunol Meth. 2005;301:102-113.
34. Pham NA, Morrison A, Schwock J et al. Quantitative image analysis of immunohistochemical stains using a CMYK color model. Diagn Pathol. 2007;27:8.
35. Skaland I, Ovestad I, Janssen EA et al. Digital image analysis improves the quality of subjective HER-2 expression scoring in breast cancer. Appl Immunohistochem Mol Morphol. 2008;16:185-190.
36. Skaland I, Řvestad I, Janssen EA et al. Comparing subjective and digital image analysis HER2/neu expression scores with conventional and modified FISH scores in breast cancer. J Clin Pathol. 2008;61:68-71.
37. Riva A, Testa-Riva F, Del Fiacco M, Lantini MS. Fine structure and cytochemistry of the intralobular ducts of the human parotid gland. J Anat. 1976;122:627-640.
38. Testa-Riva F. Ultrastructure of human submandibular gland. J. Submicr. Cytol. 1977;9:251-266.
39. Young JA, Van Lennep EW. Transport of salt in salivary glands. In: Giebisch G, Tosteson DC, Ussing HH eds. Membrane Transport in Biology. Berlin, Springer Verlag; 1979:4B563-674.
40. Lantini MS, Cossu M. Immunohistochemical investigation of the subcellular distribution of some secretory products in human salivary glands. Eur J Morph. 1998;36:230-234.
41. Tandler B, Phillips CJ. Organic secretion by striated ducts. Eur J Morph. 2000;38:233-236.
42. Groschl M, Rauh M, Wagner R et al. Identification of leptin in Human Saliva. J Clin Endocrinol Metab. 2001;86:5232-5239.
43. Bohlender J, Rauh M, Zenk J, Groschl M. Differential distribution and expression of leptin and expression of leptin and the functional leptin receptor in major salivary glands of humans. J Endocrinol. 2003;178:217-223.
44. Higa M, Shimabukuro M, Fukuchi M, Komiya I, Takasu N. Atrophic change of rat salivary gland during adenovirus-induced hiperleptinemia. Biochem. Biophys. Res. Commun. 2002;291:675-679.
45. Wolf G, Hamman A, Han DC. et al. Leptin stimulates proliferation and TGF-B expression in renal glomerular endothelial cells: Potential role in glomerulosclerosis. Kidney Int. 1999;860-872.
46. Tsuchiya T, Shimizu H, Horie T, Mori M. Expression of leptin receptor in lung: leptin as a growth factor. Eur J Pharmacol. 1999;365:273-279.
47. Zwirska-Korczala K, Adamczyk-Sowa M, Sowa P. et al. Role of leptin, ghrelin, angiotensin II and orexins in 3T3 L1 preadipocyte cells proliferation and oxidative metabolism. J Physiol Pharmacol. 2007;58(Suppl. 1):53-64.
48. Easten K H, Harry R A, Purcell W M, McLeod D. Nociceptin-induced modulation of human T cell function. Peptides 2009;30:926-934.
49. Ko MH, Kim YH, Woo RS, Kim KW. Quantitative analysis of nociceptin in blood of patients with acute and chronic pain. Neuroreport. 2002;13:1631-1633.
50. Trombella S, Vergura R, Falzarano S, Guerrini R, Calo G, Spisani S. Nociceptin/orphanin FQ stimulates human monocyte chemotaxis via NOP receptor activation. Peptides. 2005;26:1497-1502.
51. Waits PS, Purcell WM, Fulford AJ MacLeod JD. Nociceptin/ /orphanin FQ modulates human T cell function in vitro. J Neuroimmunol. 2004;149:110-120.