Estrogenic effect of ginsenoside Rg1 on APP processing in post-menopausal platelets

Platelets

Volumn 24, Issue 1, 2013, Pages 51-62

  Shi, Chun ^a   Na, Ning ^b   Zhu, Xiaoming ^c   Xu, Jie ^d  

^a GUANGZHOU MEDICAL UNIVERSITY   (China)

^b SUN YAT SEN UNIVERSITY   (China)

^c CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^d SUN YAT SEN UNIVERSITY   (China)

Author keywords

Amyloid precursor protein; Estrogen receptor; Ginsenoside Rg1; Platelets

Indexed keywords

ALPHA SECRETASE; AMYLOID PRECURSOR PROTEIN; ESTROGEN; ESTROGEN RECEPTOR; GINSENOSIDE RG 1; MITOGEN ACTIVATED PROTEIN KINASE;

ADULT; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN EXPERIMENT; NORMAL HUMAN; POSTMENOPAUSE; PRIORITY JOURNAL; PROTEIN METABOLISM; SIGNAL TRANSDUCTION; THROMBOCYTE;

ADULT; ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; BLOOD PLATELETS; ESTROGEN RECEPTOR ALPHA; ESTROGENS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FEMALE; GINSENOSIDES; HUMANS; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASES; POSTMENOPAUSE; SIGNAL TRANSDUCTION;

PANAX GINSENG;

EID: 84871725834     PISSN: 09537104     EISSN: 13691635     Source Type: Journal    
DOI: 10.3109/09537104.2012.654839     Document Type: Article

References (41)

1. Henderson VW, Buckwalter JG. Cognitive deficits of men and women with Alzheimer's disease. Neurology 1994;44: 90-96.
2. Shi C, Xu XW, Forster EL, Tang LF, Ge Z, Yew DT, Xu J. Possible role of mitochondrial dysfunction in central neurodegeneration of ovariectomized rats. Cell Biochem Funct 2008;26:172-178.
3. Manthey D, Heck S, Engert S, Behl C. Estrogen induces a rapid secretion of amyloid precursor protein via the mitogenactivated protein kinase pathway. Eur J Biochem 2001;268: 4285-4291.
4. Diaz Brinton R, Chen S, Montoya M, Hsieh D, Minaya J, Kim J, Chu HP. The women's health initiative estrogen replacement therapy is neurotrophic and neuroprotective. Neurobiol Aging 2000;21:475-496.
5. Rossouw JE, Anderson GL, Prentice RL, LaCroix AZ, Kooperberg C, Stefanick ML, Jackson RD, Beresford SA, Howard BV, Johnson KC, et al. (Writing Group for the Women's Health Initiative Investigators). Risks and benefits of estrogen plus progestin in healthy postmenopausal women, principal results From the Women's Health Initiative randomized controlled trial. JAMA 2002;288: 321-333.
6. Beral V. Million Women Study Collaborators. Breast cancer and hormone-replacement therapy in the Million Women Study. Lancet 2003;362:419-427.
7. Chan RY, Chen WF, Dong A, Guo D, Wong MS. Estrogenlike activity of ginsenoside Rg1 derived from Panax notoginseng. J Clin Endocrinol Metab 2002;87:3691-3695.
8. Lu XZ, Wang JH, Wu X, Zhou L, Wang L, Zhang XW, Cao KJ, Huang J. Ginsenoside Rg1 promotes bone marrow stromal cells proliferation via the activation of the estrogen receptor-mediated signaling pathway. Acta Pharmacol Sin 2008;29:1209-1214.
9. Punnonen R, Lukola A. Oestrogen-like effect of ginseng. Br Med J 1980;281:1110.
10. Duda RB, Taback B, Kessel B, Dooley DD, Yang H, Marchiori J, Slomovic BM, Alvarez JG. pS2 expression induced by American ginseng in MCF-7 breast cancer cells. Ann Surg Oncol 1996;3:515-520.
11. Liu J, Burdette JE, Xu H, Gu C, van Breemen RB, Bhat KP, Booth N, Constantinou AI, Pezzuto JM, Fong HH, et al. Evaluation of estrogenic activity of plant extracts for the potential treatment of menopausal symptoms. J Agric Food Chem 2001;49:2472-2479.
12. Amato P, Christophe S, Mellon PL. Estrogenic activity of herbs commonly used as remedies for menopausal symptoms. Menopause 2002;9:145-150.
13. Cui XM, Chen ZJ, Wang CL, Zeng J. Studies on saponin accumulative in regularities Panax notoginseng (Burk) F. H. Chen. Zhongguo Zhong Yao Za Zhi 2001;26:24-25.
14. Lee Y, Jin Y, Lim W, Ji S, Choi S, Jang S, Lee S. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J Steroid Biochem Mol Biol 2003;84: 463-468.
15. Chen SW, Li XH, Ye KH, Jiang ZF, Ren XD. Total saponins of Panax notoginseng protected rabbit iliac artery against balloon endothelial denudation injury. Acta Pharmacol Sin 2004;25:1151-1156.
16. Gao QG, Chen WF, Xie JX, Wong MS. Ginsenoside Rg1 protects against 6-OHDA-induced neurotoxicity in neuroblastoma SK-N-SH cells via IGF-I receptor and estrogen receptor pathways. J Neurochem 2009;109: 1338-1347.
17. Gong YS, Chen J, Zhang QZ, Zhang JT. Effect of 17betaoestradiol and ginsenoside on osteoporosis in ovariectomised rats. J Asian Nat Prod Res 2006;8:649-656.
18. Cheng Y, Shen LH, Zhang JT. Anti-amnestic and anti-aging effects of ginsenoside Rg1 and Rb1 and its mechanism of action. Acta Pharmacol Sin 2005;26:143-149.
19. Goodenough S, Schäfer M, Behl C. Estrogen-induced cell signaling in a cellular model of Alzheimer's disease. J. Steroid Biochem. Mol. Biol. 2003;84:301-305.
20. Fernandez JW, Rezai-Zadeh K, Obregon D, Tan J. EGCG functions through estrogen receptor-mediated activation of ADAM10 in the promotion of non-amyloidogenic processing of APP. FEBS Lett. 2010;584:4259-4267.
21. Yang LC, Zhang QG, Zhou CF, Yang F, Zhang YD, Wang RM, Brann DW. Extranuclear estrogen receptors mediate the neuroprotective effects of estrogen in the rat hippocampus. PLoS One 2010;5:e9851.
22. Evin G, Zhu A, Holsinger RM, Masters CL, Li QX. Proteolytic Processing of the Alzheimer's Disease Amyloid Precursor Protein in Brain and Platelets. J Neurosci Res 2003;74:386-392.
23. Zainaghi IA, Forlenza OV, Gattaz WF. Abnormal APP processing in platelets of patients with Alzheimer's disease: Correlations with membrane fluidity and cognitive decline. Psychopharmacology (Berl) 2007;192:547-553.
24. Jayachandran M, Miller V.M. Ovariectomy upregulates expression of estrogen receptors, NOS, and HSPs in porcine platelets. Am J Physiol Heart Circ Physiol 2002;283:H220-H226.
25. Oh SO, Ibe BO, Johnson C, Kurantsin-Mills J, Raj JU. Platelet-activating factor in plasma of patients with sickle cell disease in steady state. J Lab Clin Med. 1997;130:191-196.
26. Gadd RE, Clayman S. A reassessment of the use of modified tyrode's solution as a physiological medium for suspension of isolated platelets. Experientia 1972;28:719-720.
27. Hedin HL, Nilsson L, Fowler CJ. Effects of staurosporine, U-73122, wortmannin, 4-hydroxynonenal and sodium azide upon the release of secreted beta-amyloid precursor protein from human platelets in response to thrombin stimulation. Mol Cell Biochem. 2001;219:145-152.
28. Sun J, Huang YR, Harrington WR, Sheng S, Katzenellenbogen JA, Katzenellenbogen BS. Antagonists selective for estrogen receptor alpha. Endocrinology. 2002;143:941-947.
29. Shi C, Wu F, Yew DT, Xu J, Zhu Y. Bilobalide prevents apoptosis through activation of the PI3K/Akt pathway in SHSY5Y cells. Apoptosis 2010;15:715-727.
30. Zhang H, Gao Y, Dai Z, Meng T, Tu S, Yan Y. IGF-1 Reduces BACE-1 Expression in PC12 Cells via Activation of PI3-K/Akt and MAPK/ERK1/2 Signaling Pathways. Neurochem Res 2011;36:49-57.
31. Connolly TM, Jacobs JW, Condra C. An inhibitor of collagen-stimulated platelet activation from the salivary glands of the Haementeria officinalis leech. I. Identification, isolation, and characterization. J Biol Chem. 1992;267:6893-6898.
32. Roberts W, Magwenzi S, Aburima A, Naseem KM. Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 2010;116:4297-4306.
33. Canobbio I, Stefanini L, Cipolla L, Ciraolo E, Gruppi C, Balduini C, Hirsch E, Torti M. Genetic evidence for a predominant role of PI3Kbeta catalytic activity in ITAM-and integrin-mediated signaling in platelets. Blood. 2009;114: 2193-2196.
34. Grove-Strawser D, Boulware MI, Mermelstein PG. Membrane estrogen receptors activate the metabotropic glutamate receptors mGluR5 and mGluR3 to bidirectionally regulate CREB phosphorylation in female rat striatal neurons. Neurosci. 2010;170:1045-1055.
35. Lau WS, Chan RY, Guo DA, Wong MS. Ginsenoside Rg1 exerts estrogen-like activities via ligand-independent activation of ER-pathway. J Steroid Biochem Mol Biol 2008;108: 64-71.
36. Wang R, Li YN, Wang GJ, Hao HP, Wu XL, Zhou F. Neuroprotective Effects and brain transport of Ginsenoside Rg1. Chin J Nat Med, 2009;7:315-320.
37. Wilson AC, Clemente L, Liu T, Bowen RL, Meethal SV, Atwood CS. Reproductive hormones regulate the selectivepermeability of the blood-brain barrier. Biochim Biophys Acta 2008;1782:401-417.
38. Xiong J, Guo J, Huang L, Meng B, Ping Q. The use of lipidbased formulations to increase the oral bioavailability of Panax notoginseng saponins following a single oral gavage to rats. Drug Dev Ind Pharm 2008;34:65-72.
39. Li X, Tang MH, Zhang F, Yuan Z, Chen LJ, Wang XH. Quantitative determination of ginsenoside Re and Rg1 in human plasma by ultra performance liquid chromatographytandem mass spectrometry. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009;40:912-917.
40. Hardy J, Selkoe DJ. The amyloid hypothesis of Alzheimer's disease, progress and problems on the road to therapeutics. Science 2002;297:353-356.
41. Rezai-Zadeh K, Shytle D, Sun N, Mori T, Hou H, Jeanniton D, Ehrhart J, Townsend K, Zeng J, Morgan D, et al. Green Tea Epigallocatechin-3-Gallate (EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in alzheimer transgenic mice. J Neurosci 2005;25:8807-8814.