Locally enhanced early bone formation of zoledronic acid incorporated into a bone cement plug in vivo

Journal of Pharmacy and Pharmacology

Volumn 65, Issue 2, 2013, Pages 201-212

  Sörensen, Torben C ^a   Arnoldi, Jörg ^b,d   Procter, Philip ^c,d   Beimel, Claudia ^d   Jönsson, Anders ^d   Lennerås, Maria ^e   Emanuelsson, Lena ^b,f   Palmquist, Anders ^b,f   Thomsen, Peter ^b,f   Robioneck, Bernd ^d   Steckel, Hartwig ^a  

^a UNIVERSITY OF KIEL   (Germany)

^b UNIVERSITY OF GOTHENBURG   (Sweden)

^c BRUNEL UNIVERSITY   (United Kingdom)

^d Stryker Orthopaedics   (United States)

^e TATAA Biocenter AB   (Sweden)

^f Institute of Biomaterials and Cell Therapy   (Sweden)

Author keywords

bisphosphonate; bone cement; bone formation; calcium phosphate; PCR

Indexed keywords

ACID PHOSPHATASE TARTRATE RESISTANT ISOENZYME; BONE CEMENT; CALCIUM PHOSPHATE; CATHEPSIN K; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 1BETA; OSTEOCALCIN; RNA 18S; TUMOR NECROSIS FACTOR ALPHA; ZOLEDRONIC ACID;

ALKALINE PHOSPHATASE GENE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEFECT; BONE PLUG; BONE REGENERATION; CATHEPSIN K GENE; CONTROLLED STUDY; DRUG RELEASE; EQUIPMENT DESIGN; GENE; GENE IDENTIFICATION; GENE OVEREXPRESSION; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE GENE; HISTOPATHOLOGY; IN VIVO STUDY; INTERLEUKIN 1 BETA GENE; MALE; MORPHOMETRICS; NONHUMAN; OSSIFICATION; OSTEOCALCIN GENE; OSTEOLYSIS; QUANTITATIVE ANALYSIS; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RN18S GENE; SCANNING ELECTRON MICROSCOPY; TARTRATE RESISTANT ACID PHOSPHATASE GENE; TUMOUR NECROSIS FACTOR ALPHA GENE;

ANIMALS; BONE CEMENTS; BONE REGENERATION; CALCIUM PHOSPHATES; DIPHOSPHONATES; GENE EXPRESSION; IMIDAZOLES; MALE; MICROSCOPY, ELECTRON, SCANNING; OSTEOGENESIS; PROSTHESES AND IMPLANTS; RATS; RATS, SPRAGUE-DAWLEY; TIBIA;

EID: 84871720808     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/j.2042-7158.2012.01588.x     Document Type: Article

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