Ceramic drug delivery: A perspective

Journal of Biomaterials Applications

Volumn 17, Issue 4, 2003, Pages 253-264

  Paul, Willi ^a   Sharma, Chandra P ^a  

^a SREE CHITRA TIRUNAL INSTITUTE FOR MEDICAL SCIENCES AND TECHNOLOGY   (India)

Author keywords

Bone substitute; Calcium phosphates; Ceramic; Drug delivery

Indexed keywords

BONE; CALCIUM COMPOUNDS; CERAMIC MATERIALS; HYDROXYAPATITE; JOINT PROSTHESES; PROTEINS;

BONE SUBSTITUTES; CALCIUM PHOSPHATES; CERAMIC DRUG DELIVERY; MULTIPHASIC BIO-GLASSES SYNTHETIC CALCIUM PHOSPHATES CEMENTS; TRICALCIUMPHOSPHATES;

CONTROLLED DRUG DELIVERY;

BIOMATERIAL; BONE CEMENT; BONE MORPHOGENETIC PROTEIN;

BONE PROSTHESIS; CERAMICS; CHEMISTRY; DRUG DELIVERY SYSTEM; HUMAN; REVIEW; TISSUE ENGINEERING;

BIOCOMPATIBLE MATERIALS; BONE CEMENTS; BONE MORPHOGENETIC PROTEINS; BONE SUBSTITUTES; CERAMICS; DRUG DELIVERY SYSTEMS; HUMANS; TISSUE ENGINEERING;

EID: 0038322307     PISSN: 08853282     EISSN: None     Source Type: Journal    
DOI: 10.1177/0885328203017004001     Document Type: Article

References (55)

1. Langer, R. (1990). New Methods of Drug Delivery, Science, 249: 1527-1533.
2. Langer, R. (1980). Polymeric Delivery Systems for Controlled Drug Release, Chem. Eng. Commun., 6: 15-48.
3. Bajpai, P.K. and Graves Jr., G.A. (1980). Porous Ceramic Carriers for Controlled Release of Proteins, Polypeptides, Hormones and other Substances Within Human and Mammalian Species, US Patent 4,218,255.
4. Bajpai, P.K. and Benghuzzi, H.A., (1988). Ceramic Systems for Long-term Delivery of Chemicals and Biologicals, J. Biomed. Mater. Res., 22: 1245-1266.
5. Hnatyszyn, J.H.; Kossovsky, N., Gelman, A. and Sponsler, E. (1994). Drug Delivery Systems for the Future, PDA J. Pharm. Sci. Technol., 48: 247-254.
6. Mattie, D.R. and Bajpai, P.K. (1988). Analysis of the Biocompatibility of ALCAP Ceramics in Rat Femurs, J. Biomed. Mater. Res., 22: 1101.
7. Benghuzzi, H.A., Bajpai, P.K. and England, B.G. (1990). Suppression of Spermatogenesis by Means of Continuous Delivery of Danazol in Combination with Dihydrotestosterone from ALCAP Drug Delivery Devices, Biomed. Sci. Instrum., 26: 141-149.
8. Benghuzzi, H.A., Barbaro, R. M. and Bajpai, P. K. (1990). In vitro Release of Azidothymidine (AZT) by Ceramic Drug Delivery Systems, Biomed. Sci. Instrum., 26: 151-156.
9. Benghuzzi, H.A., England, B.G. and Bajpai, P.K. (1992). Controlled Release of Hydrophillic Compounds by Resorbable and Biodegradable Ceramic Drug Delivery Devices, Biomed. Sci. Instrum., 28: 179-182.
10. Benghuzzi, H.A., England, B.G. and Bajpai, P.K. (1992). Characterisation of Ceramic Drug Delivery Devices: The Effect of Various Temperature of Incubation on the Delivery of Biologicals, Biomed. Sci. Instrum., 28: 129-134.
11. Bajpai, P.K. (1988). ZCAP Ceramics, US Patent 4,778,741.
12. Pories, W.J. and Strain, W.H. (1970). In: Prasad, A.S. (ed.), Zinc and Wound Healing in Zinc Metabolism, pp. 378, Springfield, IL, Thomas.
13. Arar, H.H. and Bajpai, P.K. (1992). Insulin Delivery by Zinc Calcium Phosphate Ceramics, Biomed. Sci. Instrum., 28: 173-178.
14. Uchida, A., Shinto, Y., Araki, N. and Ono, K. (1992). Slow Release of Anticancer Drugs from Porous Calcium Hydroxyapatite Ceramic, J. Orthop. Res., 10: 440-445.
15. Itokazu, M., Sugiyama, T., Ohno, T., Wada, E. and Katagiri, Y. (1998). Development of Porous Apatite Ceramic for Local Delivery of Chemotherapeutic Agents, J. Biomed. Mater. Res., 39: 536-538.
16. Shinto, Y., Uchida, A., Korkusuz, F., Araki, N. and Ono, K. (1992). Calcium Hydroxyapatite Ceramic Used as a Delivery System for Antibiotics, J. Bone Joint Surg. Br., 74: 600-604.
17. Nagy, E.A. and Bajpai, P.K. (1994). Development of a Ceramic Matrix System for Continuous Delivery of Azidothymidine, Biomed. Sci. Instrum., 30: 181-186.
18. Cannon, M.K. and Bajpai, P.K. (1995). Continuous Delivery of Azidothymidine by Hydroxyapatite or Tricalcium Phosphate Ceramics, Biomed. Sci. Instrum., 31: 159-164.
19. Mileti, I.F. and Bajpai, P.K. (1995). Development of a Hydroxyapatite Ceramic Matrix for Continuous Delivery of Caumadin, Biomed. Sci. Instrum., 31: 177-182.
20. Apple, M.J.; Benghuzzi, H.A., Parsell, D. and England, B. (1996). Inter-relationship Between Buffer Systems and Particle Sizes of TCPL Drug Delivery Systems, Biomed. Sci. Instrum., 32: 47-53.
21. Benghuzzi, H.A., England, B.G. and Bajpai, P.K. (1991). In Vivo Delivery of Estradiol from Ceramic Drug Delivery Devices, Biomed. Sci. Instrum., 27: 181-187.
22. Benghuzzi, H.A., England, B.G. and Bajpai, P.K. (1991). Tricalcium Phosphate Amino Acid Capsules as a Drug Delivery System for Steroid Hormones, Biomed. Sci. Instrum., 27: 197-203.
23. Lambotte, J.C.; Thomazeau, H.; Cathelineau, G., Lancien, G., Minet, J. and Langlais, F. (1998). Tricalcium Phosphate, an Antibiotic Carrier: A Study Focused on Experimental Osteomyelitis in Rabbits, Chirurgie, 123(6): 572-579.
24. Zafirau, W., Parker, D., Billote, W. and Bajpai, P.K. (1996). Development of a Ceramic Device for the Continuous Local Delivery of Steroids, Biomed. Sci. Instrum., 32: 63-70.
25. Wu, H., Zheng, O., Du, J., Yan, Y. and Liu, C. (1997). A New Drug Delivery System-Ciprofloxacine/Tricalcium Phosphate Delivery Capsule (CTDC) and Its In Vitro Drug Release Pattern, J. Tongji. Med. Univ., 17(3): 160-164.
26. Yamashita, Y., Uchida, A., Yamakawa, T., Shinto, Y., Araki, and Kato, K. (1998). Treatment of Chronic Osteomyelitis Using Calcium Hydroxyapatite Ceramic Implants Impregnated with Antibiotic, Int. Orthop., 22(4): 247-251.
27. Lasserre, A., Berty, S. and Bajpai, P.K. (1997). In Vitro and In Vivo Dapsone Release from Hydroxyapatite Reservoirs, Biomed. Sci. Instrum., 33: 149-154.
28. Hotz, G. and Herr, G. (1994). Bone Substitute with Osteoinductive Biomaterials - Current and Future Clinical Applications, Int. J. Maxillofac. Surg., 23: 413-417.
29. Guicheux, J., Gauthier, O., Aguado, E.; Pilet, P., Couillaud, S., Jegou, D., Daculsi, G. and Heymann, D. (1998). Human Growth Hormone Locally Released in Bone Sites by Calcium Phosphate Biomaterial Stimulates Ceramic Bone Substitution Without Systemic Effects: A Rabbit Study, J. Bone Miner. Res., 13: 739-748.
30. Benghuzzi, H. and England, B. (2001). Biocompatibility of Steroid-HA Delivery System Using Adult Castrated Rams as Model, Biomed. Sci. Instrum., 37: 275-280.
31. Netz, D.J.; Sepulveda, P., Pandolfelli, V.C., Spadaro, A.C., Alencastre, J.B., Bentley, M.V. and Marchetti, J.M. (2001 February 1) Potential Use of Gelcasting Hydroxypatite Porous Ceramic as an Implantable Drug Delivery System, Int. J. Pharm., 213(1-2), 117-125.
32. Yapp, D.T.T.; Lloyd, D.K.; Zhu, J. and Lehnert, S.M. (1997). Tumour Treatment by Sustained Intratumoral Release of Cis-platin: Effects of Drug Alone and Combined with Radiation, Int. J. Radiat. Oncol. Biol. Phys., 39: 497-504.
33. Itokazu, M., Sugiyama, T.; Ohno, T., Wada, E. and Katagiri, Y. (1998). Development of a Porous Apatite Ceramic for Local Delivery of Chemotherapeutic Agents, J. Biomed. Mater. Res., 39: 536-538.
34. Zafirau, W., Parker, D.; Billotte, W. and Bajpai, P.K. (1996). Development of a Ceramic Device for the Continuous Local Delivery of Steroids, Biomed. Sci. Instrum., 32: 63-70.
35. Shenoy, B.D.; Udupa, N. and Nagarajkumari, A. (1997). Implantable Drug Delivery Systems for Centchroman, Indian J. Pharm. Sci., 59: 246-250.
36. Nunnery, M., Benghuzzi, H., Tucci, M.; Zizzi, T., Cason, Z.; England, B. and Hughes, J. (1999). Histopathological Evaluation of Female Reproductive Tract Exposed to Sustained Delivery of DHEA, and DHEA + E, Biomed. Sci. Instrum., 35: 79-84.
37. Zizzi, T., Nunnery, M., Cason, Z.; Tucci, M. and Benghuzzi, H. (1999). The Effects of Dehydroepiandrosterone and Dehydroepiandrosterone Sulfate on the Reproductive and Vital Organs of Male Rats, Biomed. Sci. Instrum., 35: 279-284.
38. Cason, Z., Tucci, M., England, B. and Benghuzzi, H. (1999). TCPL Delivery Devices: Endometrial Changes Associated with Exogenous Sustained Release of Ovarian Hormones, Biomed. Sci. Instrum., 35: 205-210.
39. Cason, Z., Benghuzzi, H., Tucci, M., Scott, A. and England, B. (2000). Assessment of Endometrial Function During Sustained Delivery of Estradiol and Estradiol Plus Progesterone in Ovariectomized Rats, Biomed. Sci. Instrum., 36: 221-226.
40. Mohammed, A. and Benghuzzi, H. (2000). Morphological Investigation of the Rat Kidney after Continuous Administration of Testosterone, Dihydrotestosterone, or Dehydroepiandrosterone Using TCPL Delivery Devices, Biomed. Sci. Instrum., 36: 361-366.
41. Cavett, W., Tucci, M., Cason, Z.; Lemos, L., England, B., Tsao, A. and Benghuzzi, H. (1997). Cellular Responses to Various Levels of Sustained Delivery of Testosterone in the Ventral Prostate, Biomed. Sci. Instrum., 33. 155-160.
42. Higdon, K., Scott, A., Tucci, M. Benghuzzi, H., Tsao, A., Puckett, A., Cason, Z. and Hughes, J. (2001). The Use of Estrogen, DHEA, and Diosgenin in a Sustained Delivery Setting as a Novel Treatment Approach for Osteoporosis in the Ovariectomized Adult Rat Model, Biomed. Sci. Instrum., 37: 281-286.
43. Pope, J.A., Benghuzzi, H., England, B., and Cason, Z. (2001). Morphometric Analysis of the Adrenal Compartments Exposed to Sustained Delivery of Androgens, Biomed. Sci. Instrum., 37: 155-160.
44. Stokes, K.I., Benguzzi, H.A. and Cameron, J.A. (2000). Physiological Responses Associated with Sustained Delivery of T, DHT, and AED in Male Rats, Biomed. Sci. Instrum., 36: 209-214.
45. Otsuka, M., Matsuda, Y., Fox, J.L. and Higuchi, W.I. (1995). A Novel Skeletal Drug Delivery System Using Self-setting Calcium Phosphate Cement. 9: Effects of the Mixing Solution Volume on Anticancer Drug Release from Homogeneous Drug-loaded Cement, J. Pharm. Sci., 84: 733-736.
46. Otsuka, M., Matsuda, Y., Yu, D., Wong, J., Fox, J.L. and Higuchi, W.I. (1990). A Novel Skeletal Drug Delivery System for Anti-bacterial Drugs Using Self-setting Hydroxyapatite Cement, Chem. Pharm. Bull., (Tokyo) 38: 3500-3502.
47. Solberg, B.D., Gutow, A.P. and Baumgaertner, M.R. (1999). Efficacy of Gentamycin-impregnated Resorbable Hydroxyapatite Cement in Treating Osteomyelitis in a Rat Model, J. Orthop. Trauma, 13: 102-106.
48. Otsuka, M.; Sawada, M., Matsuda, Y., Nkamura, T. and Kokubo, T. (1997). Antibiotic Delivery System Using Bioactive Bone Cement Consisting of Bis-GMA/TEGDMA Resin and Bioactive Glass Ceramics, Biomaterials, 18: 1559-1564.
49. Otsuka, M., Matsuda, Y., Kokubo, T., Yoshihara, S. Nakamura, T. and Yamamuro, T. (1995). Drug Release from a Novel Self-setting Bioactive Glass Cement Containing Cephalexin and Its Physicochemical Properties, J. Biomed. Mater. Res., 29: 33-38.
50. Paul, W. and Sharma, C.P. (1999). Development of Porous Spherical Hydroxyapatite Granules: Application Towards Protein Delivery, J. Mater. Sci. Mater. Med., 10: 383-388.
51. Paul, W. and Sharma, C.P. (1995). Antibiotic Loaded Hydroxyapatite Osteoconductive Implant Material - In Vitro Release Studies, J. Mater. Sc. Letters, 14: 1792-1794.
52. Paul, W. and Sharma, C.P. (1997). Infection Resistant Hydroxyapatite/Alginate Plastic Composite, J. Mater. Sci. Letters, 16: 2050-2051.
53. Paul, W., Jerry, N. and Sharma, C.P. (2002). Delivery of Insulin from Hydroxyapatite Ceramic Microspheres: Preliminary In Vivo Studies, J. Biomed. Mater. Res., 61: 660-662.
54. Paul, W. and Sharma, C.P. (2001). Porous Hydroxyapatite Nanoparticles for Intestinal Delivery of Insulin, Trends Biomater. Artif. Organs., 14: 37-38.
55. Dash, A.K. and Cudworth, G.C. (1998). Therapeutic Applications of Implantable Drug Delivery Systems, J. Pharmacol. Toxicol. Methods, 40: 1-12.