Arsenic trioxide (ATO) influences the gene expression of metallothioneins in human glioblastoma cells

Biological Trace Element Research

Volumn 149, Issue 3, 2012, Pages 331-339

  Falnoga, Ingrid ^a   Pevec, Andreja Zelenik ^a   Šlejkovec, Zdenka ^a   Žnidarič, Magda Tušek ^b   Zajc, Irena ^b   Jurković Mlakar, Simona ^c   Marc, Janja ^c  

^a JO EF STEFAN INSTITUTE   (Slovenia)

^b NATIONAL INSTITUTE OF BIOLOGY   (Slovenia)

^c UNIVERSITY OF LJUBLJANA   (Slovenia)

Author keywords

Arsenic trioxide; Astrocytoma; Gene expression; Glioblastoma; Metallothionein mRNA; MT 3 isoform; Resistance

Indexed keywords

ARSENIC; ARSENIC TRIOXIDE; ISOPROTEIN; MESSENGER RNA; METALLOTHIONEIN 1A; METALLOTHIONEIN 1E; METALLOTHIONEIN 1F; METALLOTHIONEIN 1X; METALLOTHIONEIN I; METALLOTHIONEIN II; METALLOTHIONEIN III; RNA 18S; UNCLASSIFIED DRUG;

ARTICLE; ASTROCYTOMA CELL; CANCER RESISTANCE; CELL DEATH; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EXPOSURE; DRUG PROTEIN BINDING; GENE EXPRESSION; GENE IDENTIFICATION; GLIOBLASTOMA; HUMAN; HUMAN CELL; METAL BINDING; NUCLEOTIDE SEQUENCE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESTRICTION MAPPING; TUMOR CELL; TUMOR CELL LINE;

ARSENICALS; CELL LINE, TUMOR; GENE EXPRESSION; GLIOBLASTOMA; HUMANS; METALLOTHIONEIN; OXIDES;

EID: 84871716776     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-012-9431-8     Document Type: Article

References (46)

1. Doyle D (2009) Notoriety to respectability: a short history of arsenic prior to present day use in haematology. BJH 145:309-317
2. Cell therapeutics Inc (2002), Trisenox, 2002. Cell Therapeutics Inc, London
3. Dilda PJ, Hogg PJ (2007) Arsenical-based cancer drugs. Cancer Treat Rev 33:542-564
4. Stupp R, Hegi ME, Masson WP et al (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10:459-466
5. Bredel M, Zentner J (2002) Brain-tumour drug resistance: the bare essentials. Lancet Oncol 3:397-406
6. Li Y, Maret W (2008) Human metallothionein metallomics. J Anal At Spectrom 23:1055-1062
7. Hidalgo J, Chung R, Penkowa M (2009) Structure and function of vertebrate metallothioneins. Met Ions Life Sci 5:279-317
8. Maret W (2011) Redox biochemistry of mammalian metallothioneins. J Biol Inorg Chem 16:1079-1086
9. Hidalgo J, Aschner M, Zatta P et al (2001) Roles of the metallothionein family of proteins in the central nervous system. Brain Res Bull 55:133-145
10. Vašak M, Meloni G (2009) Metallothionein-3, zinc, and copper in the central nervous system. Mol Ions Life Sci 5:319-351
11. Tiffany-Castiglioni E, Qian Y (2001) Astroglia as metal depots: molecular mechanisms for metal accumulation, storage and release. Neuro Toxicol 22:577-592
12. West AK, Leung JY, Chung RS (2011) Neuroprotection and regeneration by extracellular metallothionein via lipoproteinreceptor- related proteins. J Biol Inorg Chem 16:1115-1122
13. Falnoga I, Šlejkovec Z, Pucer A et al (2007) Arsenic metabolism in multiple myeloma and astrocytoma cells. Biol Trace Elem Res 116:5-28
14. Tušek Žnidarič M, Pucer A, Fatur T (2007) Metal binding of metallothioneins in human astrocytomas (U87 MG, IPDDC-2A). Biometals 20:781-792
15. Moleirinho A, Carneiro J, Matthiesen R et al (2011) Gains, losses and changes of function after gene duplication: study of the metallothionein family. PLoS One 6:e18487
16. Haq F, Mahoney M, Kiropatnick J (2003) Signalling events for metallothionein induction. Mutat Res 533:211-226
17. Sogawa CA, Asanuma M, Sogawa N et al (2001) Localization, regulation, and function of metallothionein-III/growth inhibitory factor in the brain. Acta Med Okayama 55:1-9
18. Balamurogan K, Schaffner W (2009) Regulation of metallothionein gene expression. Met Ions Life Sci 5:31-49
19. He X, Ma Q (2009) Induction of metallothionein I by Arsenic via metal-activated transcription factor 1: critical role of C-terminal cysteine residues in arsenic sensing. J Biol Chem 284:12609-12621
20. Palmiter RD, Findley SD, Withmore TE et al (1992) MT-III, a brain-specific member of the metallothionein gene family. Proc Natl Acad Sci USA 89:6333-6337
21. Aschner M, Syversen T, Souza DO, Rocha JBT (2006) Metallothioneins: mercury species-specific induction and their potential role in attenuating neurotoxicity. Exp Biol Med 231:1468-1473
22. Minami T, Miyata E, Sakamoto Y et al (2010) Induction of metallothionein in mouse cerebellum and cerebrum with low-dose thimerosal injection. Cell Biol Toxicol 26:143-152
23. Van Elteren JT, Stibilj V, Šlejkovec Z (2002) Speciation of inorganic arsenic in some bottled Slovene mineral waters using HPLCHGAFS and selective coprecipitation combined with FI-HGAFS. Water Res 36:2967-2974
24. 3 oxidation by vitamin C-cell culture studies. Biometals 25:103-113
25. Mosmann T (1983) Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63
26. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89:3354-3360
27. Šlejkovec Z, Falnoga I, Goessler W et al (2008) Analytical artefacts in the speciation of arsenic in clinical samples. Anal Chim Acta 607:83-91
28. Pfaffl MW (2001) A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 29:e45
29. NolanT HRE, Bustin SA (2006) Quantification of mRNA using real-time RT-PRC. Nat Protoc 1:1559-1582
30. Ferguson BS, Nam H, Hopkins RG, Morrison RF (2010) Impact of reference gene selection for target gene normalization on experimental outcome using real-time qPCR in adipocites. PLoS One 5 (e1528):1-10
31. Calabrese EJ (2008) Adaptive response to low doses of neurotoxins. Critical Rev Toxicol 38:463-471
32. Cui X, Okayasu R (2008) Arsenic accumulation, elimination, and interaction with copper, zinc and manganese in liver and kidney of rats. Food Chem Toxicol 46:3646-3650
33. Liu J, Cheng ML, Yang Q et al (2007) Blood metallothionein transcript as a biomarker for metal sensitivity: low blood metallothionein transcripts in arsenicosis patients from Guizhou, China. EHP 115:1101-1106
34. Amoureoux M-C, Wurch T, Pauwels PJ (1995) Modulation of metallothionein-III mRNA content and growth rate of rat C- 6glial cells by transcriortion with human 5-HT1D receptor genes. Biochem Biophys Res Commun 214:639-645
35. Jalonen TO (1996) Mechanisms of glia-mediated cadmium and zinc neurotoxicity. Chapter 11. In: Aschner M, Kimberly HK (eds) The role of glia in neurotoxicity. CRC Press, London. pp 221-224
36. Lee C, Lee YM, Rice RH (2005) Human epidermal cell protein responses to arsenite treatment in culture. Chemico-Biol Interact 155:43-54
37. Hozumi I, Suzuki JS, Kanazawa H et al (2008) Metallothionein-3 is expressed in the brain and various peripheral organs of the rat. Neurisci Lett 438:54-58
38. Chung RS, Hidalgo J, West AK (2008) New insights into molecular pathways of metallothionein mediated neuroprotection and regeneration. J Neurochem 104:14-20
39. Dantas-Barbosa C, Berghold G, Dieffenbach G, Blockus H, Puger S, Sainte-Rose C, Georger B, Vassal G, Grill J (2010) From MT3 modulation to HDACi treatment in brain tumors. J Neuro-Oncol 12:ii89
40. Peyre M, Commo F, Dantas-Barbosa C et al (2010) Portrait of ependymoma recurrence in children: biomarkers of tumor progression identified by dual-color microarray-based gene expression analysis. PLoS One 5:e12932
41. Miura N, Koizumi S (2007) Heavy metal responses of the human metallothionein isoform genes. Yakugaku Zasshi 127:665-673
42. Ngu TT, Dryden MDM, Stillman MJ (2010) Arsenic transfer between metallothionein proteins at physiological pH. Biochem Biophys Res Commun 401:69-74
43. Lee S-J, Koh J-Y (2010) Roles of zinc and metallothionein-3 in oxidative stress-induced lysosomal dysfunction, cell death, and autophagy in neurons and astrocytes. Mol Brain 3:30
44. Kanzawa T, Zhang L, Xiao L et al (2005) Arsenic trioxide induces autophagic cell death in malignant glioma cells by upregulation of mitochondrial cell death protein BNIP. Oncogene 24:980-991
45. Pucer A, Castino R, Mirković B et al (2010) Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells. Biol Chem 391:519-531
46. Kögel D, Fulda S, Mitellbronn M (2010) Therapeutic exploitation of apoptosis and autophagy for glioblastoma. Anticancer Agents Med Chem 10:438-449