Synthesis and structure-activity relationships of harmine derivatives as potential antitumor agents

European Journal of Medicinal Chemistry

Volumn 60, Issue , 2013, Pages 135-143

  Cao, Rihui ^a   Fan, Wenxi ^b   Guo, Liang ^b   Ma, Qin ^b   Zhang, Guoxian ^a   Li, Jianru ^a   Chen, Xuemei ^b   Ren, Zhenghua ^a   Qiu, Liqin ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b Xinjiang Huashidan Pharmaceutical Co Ltd   (China)

Author keywords

Carboline; Antitumor; Cytotoxic; Harmine; Structure activity relationships

Indexed keywords

7 (1,1,1 TRIFLUORO 2 HYDROXYLPROPOXY) 9 N BUTYL 1 METHYL BETA CARBOLINE; 7 (3 METHYLBUT 2 ENYLOXY) 9 (3 PHENYLPROPYL) 1 METHYL BETA CARBOLINE; 7 (3 PHENYLPROPOXY) 2 BENZYL 9 ETHYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 (3 PHENYLPROPOXY) 9 ETHYL 1 METHYL BETA CARBOLINE; 7 (3 PHENYLPROPOXY) 9 ISOBUTYL 1 METHYL BETA CARBOLINE; 7 (3 PHENYLPROPOXY) 9 N BUTYL 1 METHYL BETA CARBOLINE; 7 (3 PHENYLPROPOXYL) 9 (3 PHENYLPROPYL) 1 METHYL BETA CARBOLINE; 7 (PENTAN 3 YLOXY) 9 (3 PHENYLPROPYL) 1 METHYL BETA CARBOLINE; 7 (PERFLUOROBENZYLOXY) 9 N BUTYL 1 METHYL BETA CARBOLINE; 7 BENZYLOXY 2 BENZYL 9 ETHYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 BENZYLOXY 2 BENZYL 9 N BUTYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 BENZYLOXY 9 ETHYL 1 METHYL BETA CARBOLINE; 7 BENZYLOXY 9 N BUTYL 1 METHYL BETA CARBOLINE; 7 BUTOXY 2 BENZYL 9 ETHYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 DECYLOXY 9 ETHYL 1 METHYL BETA CARBOLINE; 7 ISOBUTOXY 2 BENZYL 9 ETHYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 ISOBUTOXY 2 BENZYL 9 N BUTYL 1 METHYL BETA CARBOLINIUM BROMIDE; 7 ISOBUTOXY 9 (3 PHENYLPROPYL) 1 METHYL BETA CARBOLINE; 7 ISOBUTOXY 9 ETHYL 1 METHYL BETA CARBOLINE; 7 ISOBUTOXY 9 ISOBUTYL 1 METHYL BETA CARBOLINE; 7 ISOBUTOXY 9 N BUTYL 1 METHYL BETA CARBOLINE; 7 ISOPROPOXY 9 ETHYL 1 METHYL BETA CARBOLINE; 7 N BUTOXY 9 (3 PHENYLPROPYL) 1 METHYL BETA CARBOLINE; 7 N BUTOXY 9 ETHYL 1 METHYL BETA CARBOLINE; 7 N OCTYLOXY 2 BENZYL 9 N BUTYL 1 METHYL BETA CARBOLINIUM BROMATE; 7 OCTYLOXY 9 N BUTYL 1 METHYL BETA CARBOLINE; 9 N BUTYL 1 METHYL 7 (PENTAN 3 YLOXY) BETA CARBOLINE; ANTINEOPLASTIC AGENT; HARMINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CHEMICAL STRUCTURE; CONTROLLED STUDY; DEMETHYLATION; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; MOUSE; NEUROTOXICITY; NONHUMAN; PHARMACOPHORE; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HARMINE; HUMANS; MICE; MOLECULAR STRUCTURE; NEOPLASMS, EXPERIMENTAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84871716160     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.11.045     Document Type: Article

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