Zymosan induces NADPH oxidase activation in human neutrophils by inducing the phosphorylation of p47phox and the activation of Rac2: Involvement of protein tyrosine kinases, PI3Kinase, PKC, ERK1/2 and p38MAPkinase

Biochemical Pharmacology

Volumn 85, Issue 1, 2013, Pages 92-100

  Makni Maalej, Karama ^a,b   Chiandotto, Mélanie ^a,b   Hurtado Nedelec, Margarita ^a,b,c   Bedouhene, Samia ^a,b   Gougerot Pocidalo, Marie Anne ^a,b,c   Dang, Pham My Chan ^a,b   El Benna, Jamel ^a,b  

^a CENTRE DE RECHERCHE BIOMÉDICALE BICHAT BEAUJON CRB3   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c BICHAT HOSPITAL   (France)

Author keywords

NADPH oxidase; Neutrophils; p47phox; Rac2; ROS; Signaling

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GENISTEIN; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHORBOL 13 ACETATE 12 MYRISTATE; PHOSPHATIDYLINOSITOL 3 KINASE; RAC2 PROTEIN; RECOMBINANT GRANULOCYTE COLONY STIMULATING FACTOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UO 126; WORTMANNIN; ZYMOSAN;

ARTICLE; CONTROLLED STUDY; DRUG TARGETING; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; NEUTROPHIL; OPSONIZATION; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ENZYME ACTIVATION; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; NADPH OXIDASE; NEUTROPHILS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE C; PROTEIN-TYROSINE KINASES; RAC GTP-BINDING PROTEINS; REACTIVE OXYGEN SPECIES; ZYMOSAN;

EID: 84871716032     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2012.10.010     Document Type: Article

References (33)

1. C. Nathan Neutrophils and immunity: challenges and opportunities Nat Rev Immunol 6 2006 173 182
2. V. Witko-Sarsat, P. Rieu, B. Descamps-Latscha, P. Lesavre, and L. Halbwachs-Mecarelli Neutrophils: molecules, functions and pathophysiological aspects Lab Invest 80 2000 617 653
3. T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat Immunol 11 2010 373 384
4. H. Kumar, T. Kawai, and S. Akira Toll-like receptors and innate immunity Biochem Biophys Res Commun 388 2009 621 625
5. W.L. Lee, R.E. Harrison, and S. Grinstein Phagocytosis by neutrophils Microbes Infect 5 2003 1299 1306
6. B.M. Babior NADPH oxidase: an update Blood 93 1999 1464 1476
7. Y. Groemping, and K. Rittinger Activation and assembly of the NADPH oxidase: a structural perspective Biochem J 386 2005 401 416
8. J. El-Benna, P.M.C. Dang, and M.A. Gougerot-Pocidalo Priming of the neutrophil NADPH oxidase activation: role of p47phox phosphorylation and NOX2 mobilization to the plasma membrane Semin Immunopathol 30 2008 279 289
9. W.M. Nauseef How human neutrophils kill and degrade microbes: an integrated view Immunol Rev 219 2007 88 102
10. J. El-Benna, P.M.C. Dang, M.A. Gougerot-Pocidalo, J.C. Marie, and F. Braut-Boucher p47phox, the phagocyte NADPH oxidase/NOX2 organizer: structure, phosphorylation and implication in diseases Exp Mol Med 41 2009 217 225
11. J. El-Benna, P.M.C. Dang, M.A. Gougerot-Pocidalo, and C. Elbim Phagocyte NADPH oxidase: a multicomponent enzyme essential for host defenses Arch Immunol Ther Exp (Warsz) 53 2005 199 206
12. J. Jacobi, S. Sela, H.I. Cohen, J. Chezar, and B. Kristal Priming of polymorphonuclear leukocytes: a culprit in the initiation of endothelial cell injury Am J Physiol Heart Circ Physiol 290 2006 H2051 H2058
13. W.C. Conner, C.M. Gallagher, T.J. Miner, H. Tavaf-Motamen, K.M. Wolcott, and T. Shea-Donohue Neutrophil priming state predicts capillary leak after gut ischemia in rats J Surg Res 84 1999 24 30
14. P.M. Dang, DewasC, Gaudry, M. Fay, Pedruzzi, and M.A. Gougerot-Pocidalo Priming of human neutrophil respiratory burst by granulocyte/macrophage colony-stimulating factor (GM-CSF) involves partial phosphorylation of p47(phox) J Biol Chem 274 1999 20704 20708
15. C. Dewas, P.M.C. Dang, M.A. Gougerot-Pocidalo, and J. El-Benna TNF-alpha induces phosphorylation of p47(phox) in human neutrophils: partial phosphorylation of p47phox is a common event of priming of human neutrophils by TNF-alpha and granulocyte-macrophage colony-stimulating factor J Immunol 171 2003 4392 4398
16. P.M.C. Dang, A. Stensballe, T. Boussetta, H. Raad, C. Dewas, and Y. Kroviarski A specific p47phox -serine phosphorylated by convergent MAPKs mediates neutrophil NADPH oxidase priming at inflammatory sites J Clin Invest 116 2006 2033 2043
17. T. Boussetta, M.A. Gougerot-Pocidalo, G. Hayem, S. Ciappelloni, H. Raad, and R. Arabi Derkawi The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils Blood 116 2010 5795 5802
18. F.R. DeLeo, J. Renee, S. McCormick, M. Nakamura, M. Apicella, and J.P. Weiss Neutrophils exposed to bacterial lipopolysaccharide upregulate NADPH oxidase assembly J Clin Invest 101 1998 455 463
19. R.A. Ward, M. Nakamura, and K.R. McLeish Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules J Biol Chem 275 2000 36713 36719
20. C. Dostert, and J. Tschopp DEteCTINg fungal pathogens Nat Immunol 8 2007 17 18
21. P.R. Taylor, S.V. Tsoni, J.A. Willment, K.M. Dennehy, M. Rosas, and H. Findon Dectin-1 is required for beta-glucan recognition and control of fungal infection Nat Immunol 8 2007 31 38
22. B.N. Gantner, R.M. Simmons, S.J. Canavera, S. Akira, and D.M. Underhill Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2 J Exp Med 197 2003 1107 1117
23. F. Hayashi, T.K. Means, and A.D. Luster Toll-like receptors stimulate human neutrophil function Blood 102 2003 2660 2669
24. D.H. Elsori, V.P. Yakubenko, T. Roome, P.S. Thiagarajan, A. Bhattacharjee, and S.P. Yadav Protein kinase C d is a critical component of Dectin-1 signaling in primary human monocytes J Leukoc Biol 90 2011 599 611
25. V. Benard, B.P. Bohl, and G.M. Bokoch Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases J Biol Chem 274 1999 13198 13204
26. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
27. H. Towbin, T. Staehelin, and J. Gordon Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications Proc Natl Acad Sci USA 76 1979 4350 4354
28. C. Dahlgren, and A. Karlsson Respiratory burst in human neutrophils J Immunol Methods 232 1999 3 14
29. J.A. Willment, S. Gordon, and G.D. Brown Characterization of the human beta-glucan receptor and its alternatively spliced isoforms J Biol Chem 276 2001 43818 43823
30. L.M. Lavigne, J.E. Albina, and J.S. Reichner Beta-glucan is a fungal determinant for adhesion-dependent human neutrophil functions J Immunol 177 2006 8667 8675
31. C.Y. Lee, M. Herant, and V. Heinrich Target-specific mechnics of phagocytosis: protrusive neutrophil response to zymosan differs from the uptake of antibody-tagged pathogens J Cell Sci 124 2011 1106 1114
32. J. Herre, A.S. Marshall, E. Caron, A.D. Edwards, D.L. Williams, and E. Schweighoffer Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages Blood 104 2004 4038 4045
33. A. Fontayne, P.M. Dang, M.A. Gougerot-Pocidalo, and J. El-Benna Phosphorylation of p47phox sites by PKC alpha, beta II, delta, and zeta: effect on binding to p22phox and on NADPH oxidase activation Biochemistry 41 2002 7743 7750