Development of a long acting human growth hormone analog suitable for once a week dosing

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 2, 2013, Pages 402-406

  Palanki, Moorthy S S ^a   Bhat, Abhijit ^a   Bolanos, Ben ^a   Brunel, Florence ^a   Del Rosario, Joselyn ^a   Dettling, Danielle ^a   Horn, Mark ^a   Lappe, Rodney ^a   Preston, Ryan ^a   Sievers, Annette ^a   Stankovic, Nebojsa ^a   Woodnut, Gary ^a   Chen, Gang ^a  

^a PFIZER INC   (United States)

Author keywords

Antibody; CovX body; Disulphide linker; Human growth hormone

Indexed keywords

ANTIBODY CONJUGATE; DRUG CARRIER; GROWTH HORMONE; GROWTH HORMONE DERIVATIVE; GROWTH HORMONE RECEPTOR; IMMUNOGLOBULIN F(AB) FRAGMENT; LONG ACTING DRUG; LYSINE; MACROGOL;

ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISULFIDE BOND; DRUG ACTIVITY; DRUG SYNTHESIS; EXPERIMENTAL MODEL; FEMALE; HYPOPHYSECTOMY; IN VIVO STUDY; NONHUMAN; RAT; WEIGHT GAIN;

ANIMALS; ANTIBODIES; CRYSTALLOGRAPHY, X-RAY; DISEASE MODELS, ANIMAL; DRUG ADMINISTRATION SCHEDULE; DRUG DESIGN; FRUCTOSE-BISPHOSPHATE ALDOLASE; HUMAN GROWTH HORMONE; HUMANS; HYPOPHYSECTOMY; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RATS; TIME FACTORS;

RATTUS;

EID: 84871715002     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.11.104     Document Type: Article

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