Evolution of potent and stable placental-growth-factor-1-targeting covx-bodies from phage display peptide discovery

Journal of Medicinal Chemistry

Volumn 54, Issue 5, 2011, Pages 1256-1265

  Bower, Kristen E ^a   Lam, Son N ^a   Oates, Bryan D ^a   Del Rosario, Joselyn R ^a   Corner, Emily ^a   Osothprarop, Trina F ^a   Kinhikar, Arvind G ^a   Hoye, Julie A ^a   Preston, R Ryan ^a   Murphy, Robert E ^a   Campbell, Lioudmila A ^a   Huang, Hanhua ^a   Jimenez, Judith ^a   Cao, Xia ^a   Chen, Gang ^a   Ainekulu, Zemeda W ^a   Datt, Aakash B ^a   Levin, Nancy J ^a   Doppalapudi, Venkata R ^a   Pirie Shepherd, Steven R ^a   Bradshaw, Curt ^a   Woodnutt, Gary ^a   Lappe, Rodney W ^a   more..

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COVX BODY; GROWTH FACTOR; PEPTIDE DERIVATIVE; PLACENTAL GROWTH FACTOR 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONJUGATION; CONTROLLED STUDY; DRUG HALF LIFE; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; IC 50; IN VITRO STUDY; IN VIVO STUDY; MACACA; MALE; MOUSE; NONHUMAN; PHAGE DISPLAY;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIBODIES; BINDING, COMPETITIVE; CROSS REACTIONS; DRUG STABILITY; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; MACACA FASCICULARIS; MALE; MICE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PEPTIDES; PREGNANCY PROTEINS; PROTEIN BINDING; STRUCTURE-ACTIVITY RELATIONSHIP; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1;

EID: 79952256219     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm101226k     Document Type: Article

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