Effects of the radiocontrast agent iodixanol on endothelial cell morphology and function

Vascular Pharmacology

Volumn 58, Issue 1-2, 2013, Pages 39-47

  Ronda, Nicoletta ^a   Potì, Francesco ^a   Palmisano, Alessandra ^a   Gatti, Rita ^a   Orlandini, Guido ^a   Maggiore, Umberto ^a   Cabassi, Aderville ^a   Regolisti, Giuseppe ^a   Fiaccadori, Enrico ^a  

^a UNIVERSITY OF PARMA   (Italy)

Author keywords

Endothelial cells; Inflammation; Iodixanol; N acetylcysteine; Oxidative stress; Rosuvastatin

Indexed keywords

ACETYLCYSTEINE; CHAPERONIN 60; INTERLEUKIN 6; INTERLEUKIN 8; IODIXANOL; MONOCYTE CHEMOTACTIC PROTEIN 1; ROSUVASTATIN; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ARTICLE; CELL MEMBRANE; CELL STRUCTURE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DRUG EFFECT; ENDOTHELIUM CELL; HIGH RISK PATIENT; HUMAN; HUMAN CELL; IN VITRO STUDY; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN SECRETION; RADIOLOGICAL PROCEDURES;

ACETYLCYSTEINE; CELL MEMBRANE; CELLS, CULTURED; CHAPERONIN 60; CONTRAST MEDIA; ENDOTHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; FLUOROBENZENES; HUMANS; IMMUNOENZYME TECHNIQUES; MICROSCOPY, CONFOCAL; OXIDATIVE STRESS; PYRIMIDINES; SULFONAMIDES; TRIIODOBENZOIC ACIDS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84871713361     PISSN: 15371891     EISSN: 18793649     Source Type: Journal    
DOI: 10.1016/j.vph.2012.08.005     Document Type: Article

References (58)

1. Andreucci M., Lucisano G., Faga T., Bertucci B., Tamburrini O., Pisani A., Sabbatini M., Salzano S., Vitale M., Fuiano G., Michael A. Differential activation of signaling pathways involved in cell death, survival and inflammation by radiocontrast media in human renal proximal tubular cells. Toxicol. Sci. 2011, 19(2):408-416.
2. Basile D.P. The endothelial cell in ischemic acute kidney injury: implications for acute and chronic function. Kidney Int. 2007, 72(2):151-156.
3. Basile D.P., Friederich J.L., Spahic J., Knipe N., Mang H., Leonard E.C., Changizi-Ashtiyani S., Bacallao R.L., Molitoris B.A., Sutton T.A. Impaired endothelial proliferation and mesenchymal transition contribute to vascular rarefaction following acute kidney injury. Am. J. Physiol. Renal Physiol. 2011, 300:F721-F733.
4. Biswas D., Sen G., Sarkar A., Biswas T. Atorvastatin acts synergistically with N-acetyl cysteine to provide therapeutic advantage against Fas-activated erythrocyte apoptosis during chronic arsenic exposure in rats. Toxicol. Appl. Pharmacol. 2011, 250(1):39-53.
5. Briguori C., Quintavalle C., De Micco F., Condorelli G. Nephrotoxicity of contrast media and protective effects of acetylcysteine. Arch. Toxicol. 2011, 85(3):165-173.
6. Doria A., Sherer Y., Meroni P.L., Shoenfeld Y. Inflammation and accelerated atherosclerosis: basic mechanisms. Rheum. Dis. Clin. North Am. 2005, 31(2):355-362.
7. Erbs S., Beck E.B., Linke A., Adams V., Gielen S., Kränkel N., Möbius-Winkler S., Höllriegel R., Thiele H., Hambrecht R., Schuler G. High-dose rosuvastatin in chronic heart failure promotes vasculogenesis, corrects endothelial function, and improves cardiac remodeling - results from a randomized, double-blind, and placebo-controlled study. Int. J. Cardiol. 2011, 146(1):56-63.
8. Franke R.P., Fuhrmann R., Hiebl B., Jung F. Influence of various radiographic contrast media on the buckling of endothelial cells. Microvasc. Res. 2008, 76(2):110-113.
9. Franke R.P., Fuhrmann R., Hiebl B., Jung F. Influence of radiographic contrast media (iodixanol und iomeprol) on the morphology of human arterial and venous endothelial cells on extracellular matrix in vitro. Clin. Hemorheol. Microcirc. 2011, 48(1):41-56.
10. Ghaisas M.M., Dandawate P.R., Zawar S.A., Ahire Y.S., Gandhi S.P. Antioxidant, antinociceptive and anti-inflammatory activities of atorvastatin and rosuvastatin in various experimental models. Inflammopharmacology 2010, 18(4):169-177.
11. Grundtman C., Kreutmayer S.B., Almanzar G., Wick M.C., Wick G. Heat shock protein 60 and immune inflammatory responses in atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 2011, 31(5):960-968.
12. Harmon R.C., Duffy S.P., Terneus M.V., Ball J.G., Valentovic M.A. Characterization of a novel model for investigation of radiocontrast nephrotoxicity. Nephrol. Dial. Transplant. 2009, 24(3):763-768.
13. Heyman S.N., Rosen S., Khamaisi M., Idée J.M., Rosenberger C. Reactive oxygen species and the pathogenesis of radiocontrast-induced nephropathy. Invest. Radiol. 2010, 45(4):188-195.
14. Hörbelt M., Lee S.Y., Mang H.E., Knipe N.L., Sado Y., Kribben A., Sutton T.A. Acute and chronic microvascular alterations in a mouse model of ischemic acute kidney injury. Am. J. Physiol. Renal Physiol. 2007, 293(3):F688-F695.
15. Ikawa S., Weinberg R.A. An interaction between p21ras and heat shock protein hsp60, a chaperonin. Proc. Natl. Acad. Sci. U. S. A. 1992, 89:2012-2016.
16. ACT Investigators Acetylcysteine for prevention of renal outcomes in patients undergoing coronary and peripheral vascular angiography. Main results from the randomized acetylcysteine for contrast-induced nephropathy trial (ACT). Circulation 2011, 124(11):1250-1259.
17. Jabara R., Gadesam R.R., Pendyala L.K., Knopf W.D., Chronos N., Chen J.P., Viel K., King S.B., Manoukian S.V. Impact of the definition utilized on the rate of contrast-induced nephropathy in percutaneous coronary intervention. Am. J. Cardiol. 2009, 103(12):1657-1662.
18. James M.T., Ghali W.A., Knudtson M.L., Ravani P., Tonelli M., Faris P., Pannu N., Manns B.J., Klarenbach S.W., Hemmelgarn B.R. Alberta Provincial Project for Outcome Assessment in Coronary Heart Disease (APPROACH) Investigators. Association between acute kidney injury and cardiovascular and renal outcomes after coronary angiography. Circulation 2011, 123:409-416.
19. Ji L., Liu T., Chen Y., Wang Z. Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity. J. Cell. Biochem. 2009, 108(2):424-432.
20. Johnson W.H., Lloyd T.R., Victorica B.E., Zales V.R., Epstein M.L., Leff R.D., Ardinger R.H., Slovis T.L., Johnson J.A., Marsters P.A. Iodixanol pharmacokinetics in children. Pediatr. Cardiol. 2001, 22:223-227.
21. Jones M., Gupta R.S., Englesberg E. Enhancement in amount of P1 (hsp60) in mutants of Chinese hamster ovary (CHO-K1) cells exhibiting increases in the A system of amino acid transport. Proc. Natl. Acad. Sci. U. S. A. 1994, 91:858-862.
22. Kinsey G.R., Li L., Okusa M.D. Inflammation in acute kidney injury. Nephron Exp. Nephrol. 2008, 109(4):e102-e107.
23. Knoflach M., Kiechl S., Kind M., Said M., Sief R., Gisinger M., van der Zee R., Gaston H., Jarosh E., Willeit J., Wick G. Cardiovascular risk factors and atherosclerosis in young males: ARMY study (Atherosclerosis Risk-Factors in Male Youngsters). Circulation 2003, 108(9):1064-1069.
24. Lee H.C., Sheu S.H., Yen H.W., Lai W.T., Chang J.G. JNK/ATF2 pathway is involved in iodinated contrast media-induced apoptosis. Am. J. Nephrol. 2010, 31(2):125-133.
25. Lee H.C., Chang J.G., Yen H.W., Liu I.H., Lai W.T., Sheu S.H. Ionic contrast media induced more apoptosis in diabetic kidney than non-ionic contrast media. J. Nephrol. 2011, 24(3):376-380.
26. Lee H.C., Sheu S.H., Liu I.H., Lee C.C., Hsieh C.C., Yen H.W., Lai W.T., Chang J.G. Impact of short-duration administration of N-acetylcysteine, probucol and ascorbic acid on contrast-induced cytotoxicity. J. Nephrol. 2012, 25(1):56-62.
27. Limbruno U., Petronio A.S., Amoroso G., Baglini R., Paterni G., Merelli A., Mariotti R., De Caterina R., Mariani M. The impact of coronary artery disease on the coronary vasomotor response to non-ionic contrast media. Circulation 2000, 101:491-497.
28. Liuni A., Luca M.C., Gori T., Parker J.D. Rosuvastatin prevents conduit artery endothelial dysfunction induced by ischemia and reperfusion by a cyclooxygenase-2-dependent mechanism. J. Am. Coll. Cardiol. 2010, 55(10):1002-1006.
29. Masha A., Brocato L., Dinatale S., Mascia C., Biasi F., Martina V. N-acetylcysteine is able to reduce the oxidation status and the endothelial activation after a high-glucose content meal in patients with type 2 diabetes mellitus. J. Endocrinol. Invest. 2009, 32(4):352-356.
30. McCullough P.A. Contrast-induced acute kidney injury. J. Am. Coll. Cardiol. 2008, 51:1419-1428.
31. Nash K., Hafeez A., Hou S. Hospital-acquired renal insufficiency. Am. J. Kidney Dis. 2002, 39(5):930-936.
32. O'Donnell D.H., Maloney M.A., Bouchier-Hayes D.J., Lee M.J. Contrast-induced nephrotoxicity: possible synergistic effect of stress hyperglycemia. Am. J. Radiol. 2010, 195:W45-W49.
33. Orlandini G., Gatti R., Gazzola G.C., Borghetti A., Ronda N. Receptor-ligand internalization. Techniques in Confocal Microscopy 2010, 175-188. Academic Press, San Diego. P.M. Conn (Ed.).
34. Parasassi T., Brunelli R., Costa G., De Spirito M., Krasnowska E., Lundeberg T., Pittaluga E., Ursini F. Thiol redox transitions in cell signaling: a lesson from N-acetylcysteine. Sci. World J. 2010, 10:1192-1202.
35. Patti G., Ricottini E., Nusca A., Colonna G., Pasceri V., D'Ambrosio A., Montinaro A., Di Sciascio G. Short-term, high-dose atorvastatin pretreatment to prevent contrast-induced nephropathy in patients with acute coronary syndromes undergoing percutaneous coronary intervention (from the ARMYDA-CIN [Atorvastatin for Reduction of Myocardial Damage during Angioplasty-Contrast-Induced Nephropathy] Trial). Am. J. Cardiol. 2011, 108(1):1-7.
36. Payne R.W. A Guide to ANOVA and Design in Genstat Realease 13 2010, VSN International, Hemel Hempstead, UK.
37. Payne R.W. GenStat Release 13 Reference Manual, Part 3 Procedure Library PL21 2010, VSN International, Hemel Hempstead, UK.
38. Persson P.B., Tepel M. Contrast medium-induced nephropathy: the pathophysiology. Kidney Int. 2006, 100:S8-S10.
39. Quintavalle C., Brebca M., De Micco F., Fiore D., Romano S., Romano M.F., Apone F., Bianco A., Zabatta M.A., Troncone G., Briguiri C., Condorelli G. In vivo and in vitro assessment of pathways involved in contrast media-induced renal cell apoptosis. Cell Death Dis 2011, 2:e155. 10.1038/cddis.2011.38.
40. Ridker P.M., Danielson E., Fonseca F.A., Genest J., Gotto A.M.Jr, Kastelein J.J., Koenig W., Libby P., Lorenzatti A.J., McFaiden J.G., Nordestgaard B.G., Shepherd J., Willerson J.T., Glynn R.J. JUPITER Study Group. Rosuvastatin to prevent vascular events in men and women with elevated C-reactive protein. N. Engl. J. Med. 2008, 359(21):2195-2207.
41. Ronda N., Gatti R., Orlandini G., Gazzola G.C., Borghetti A. Binding and internalization of human IgG by living cultured endothelial cells. Clin. Exp. Immunol. 1997, 109:211-216.
42. Schett G., Xu Q., Amberger A., Van der Zee R., Recheis H., Willeit J., Wick G. Autoantibodies against heat shock protein 60 mediate endothelial cytotoxicity. J. Clin. Invest. 1995, 96:2569-2577.
43. Sendeski M., Patzak A., Persson P.B. Constriction of the vasa recta, the vessels supplying the area at risk for acute kidney injury, by four different iodinated contrast media, evaluating ionic, non-ionic, monomeric and dimeric agents. Invest. Radiol. 2010, 45(8):453-457.
44. Shoenfeld Y., Gerli R., Doria A., Matsuura E., Cerinic M.M., Ronda N., Jara L.J., Abu-Shakra M., Meroni P.L., Sherer Y. Accelerated atherosclerosis in autoimmune rheumatic diseases. Circulation 2005, 112:3337-3347.
45. Sochman J. N-acetylcysteine somewhere between Scylla and Charybdis. J. Am. Coll. Cardiol. 2010, 56(13):1067.
46. Solomon R.J., Mehran R., Natarajan M.K., Doucet S., Katholi R.E., Staniloae C.S., Sharma S.K., Labinaz M., Gerlormini J.L., Barrett B.J. Contrast-induced nephropathy and long-term adverse events: cause and effect?. Clin. J. Am. Soc. Nephrol. 2009, 4(7):1162-1169.
47. Soltys B.J., Gupta R.S. Cell surface localization of the 60kDa heat shock chaperonin protein (hsp60) in mammalian cells. Cell Biol. Int. 1997, 21(5):315-320.
48. Soltys B.J., Gupta R.S. Mitochondrial-matrix proteins at unexpected locations: are they exported?. Trends Biochem. Sci. 1999, 24(5):174-177.
49. Suh J.W., Choi D.J., Chang H.J., Cho Y.S., Youn T.J., Chae I.H., Kim K.I., Kim C.H., Kim H.S., Oh B.H., Park Y.B. HMG-CoA reductase inhibitor improves endothelial dysfunction in spontaneous hypertensive rats via down-regulation of caveolin-1 and activation of endothelial nitric oxide synthase. Korean Med. Sci. 2010, 25(1):16-23.
50. Svaland M.G., Haider T., Langseth-Manrique K., Andrew E., Hals P.A. Human pharmacokinetics of iodixanol. Invest. Radiol. 1992, 27(2):130-133.
51. Thiele H., Hildebrand L., Schirdewahn C., Eitel I., Adams V., Fuernau G., Erbs S., Linke A., Diedrich K.W., Nowak M., Desch S., Gutberlet M., Schuler G. Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate Percutaneous Coronary Intervention Acute Myocardial Infarction N-ACC) trial. J. Am. Coll. Cardiol. 2010, 55(20):2201-2209.
52. Toso A., Maioli M., Leoncini M., Gallopin M., Tedeschi D., Micheletti C., Manzone C., Amato M., Bellandi F. Usefulness of atorvastatin (80mg) in prevention of contrast-induced nephropathy in patients with chronic renal disease. Am. J. Cardiol. 2010, 105(3):288-292.
53. Tumlin J., Stacul F., Adam A., Becker C.R., Davidson C., Lameire N., McCullough P.A. CIN consensus working panel. Pathophysiology of contrast-induced nephropathy. Am. J. Cardiol. 2006, 98(6A):14K-20K.
54. Uggeri J., Gatti R., Belletti S., Scandroglio R., Corradini R., Rotoli B.M., Orlandini G. Calcein-AM is a detector of intracellular oxidative activity. Histochem. Cell Biol. 2004, 122(5):499-505.
55. Urban M.B., Schreck R., Baeuerle P.A. KF-kappaB contacts DNA by a heterodimer of the p50 and p65 subunit. EMBO J. 1991, 10(7):1817-1825.
56. Wells A.D., Rai S.K., Salvato M.S., Band H., Malkovsky M. Restoration of MHC class I surface expression and endogenous antigen presentation by a molecular chaperone. Scand. J. Immunol. 1997, 45:605-612.
57. Xinwei J., Xianghua F., Jing Z., Xinshun G., Ling X., Weize F., Guozhen H., Yunfa J., Weili W., Shigiang L. Comparison of usefulness of simvastatin 20mg versus 80mg in preventing contrast-induced nephropathy in patients with acute coronary syndrome undergoing percutaneous coronary intervention. Am. J. Cardiol. 2009, 104(4):519-524.
58. Xu Q., Schett G., Seitz C.S., Hu Y., Gupta R.S., Wick G. Surface staining and cytotoxic activity of heat-shock protein 60 antibody in stressed aortic endothelial cells. Circ. Res. 1994, 75:1078-1085.