Low levels of serum n-3 polyunsaturated fatty acids are associated with worse heart failure-free survival in patients after acute myocardial infarction

Circulation Journal

Volumn 77, Issue 1, 2013, Pages 153-162

  Hara, Masahiko ^a   Sakata, Yasuhiko ^a,b   Nakatani, Daisaku ^a   Suna, Shinichiro ^a   Usami, Masaya ^a   Matsumoto, Sen ^a   Hamasaki, Toshimitsu ^a   Doi, Yasuji ^c   Nishino, Masami ^d   Sato, Hiroshi ^e   Kitamura, Tetsuhisa ^f   Nanto, Shinsuke ^a   Hori, Masatsugu ^g   Komuro, Issei ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b TOHOKU UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c Osaka Saiseikai Senri Hospital   (Japan)

^d OSAKA ROSAI HOSPITAL   (Japan)

^e KWANSEI GAKUIN UNIVERSITY   (Japan)

^f OSAKA UNIVERSITY HOSPITAL   (Japan)

^g OSAKA GENERAL MEDICAL CENTER   (Japan)

Author keywords

Acute myocardial infarction; Docosahexaenoic acid; Eicosapentaenoic acid; Heart failure; N 3 polyunsaturated fatty acids

Indexed keywords

ANGIOTENSIN 2 RECEPTOR ANTAGONIST; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CHOLESTEROL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOCOSAHEXAENOIC ACID; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; ICOSAPENTAENOIC ACID; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OMEGA 3 FATTY ACID; TRIACYLGLYCEROL;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; DISEASE ASSOCIATION; DYSLIPIDEMIA; FEMALE; GLOMERULUS FILTRATION RATE; HEART DEATH; HEART FAILURE; HOSPITALIZATION; HUMAN; KAPLAN MEIER METHOD; MAJOR CLINICAL STUDY; MALE; PROPENSITY SCORE; REGRESSION ANALYSIS;

AGED; DISEASE-FREE SURVIVAL; DOCOSAHEXAENOIC ACIDS; EICOSAPENTAENOIC ACID; FEMALE; HEART FAILURE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL INFARCTION; SEX FACTORS; SURVIVAL RATE;

EID: 84871687188     PISSN: 13469843     EISSN: 13474820     Source Type: Journal    
DOI: 10.1253/circj.CJ-12-0875     Document Type: Article

References (22)

1. De Caterina R. n-3 fatty acids in cardiovascular disease. N Engl J Med 2011; 364: 2439-2450.
2. Balk EM, Lichtenstein AH, Chung M, Kupelnick B, Chew P, Lau J. Effects of omega-3 fatty acids on serum markers of cardiovascular disease risk: A systematic review. Atherosclerosis 2006; 189: 19-30.
3. Kromhout D, Giltay EJ, Geleijnse JM; Alpha Omega Trial Group. n-3 fatty acids and cardiovascular events after myocardial infarction. N Engl J Med 2010; 363: 2015-2026.
4. Rauch B, Schiele R, Schneider S, Diller F, Victor N, Gohlke H, et al; OMEGA Study Group. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation 2010; 122: 2152-2159.
5. Wang C, Harris WS, Chung M, Lichtenstein AH, Balk EM, Kupelnick B, et al. n-3 Fatty acids from fish or fish-oil supplements, but not alpha-linolenic acid, benefit cardiovascular disease outcomes in primary- and secondary-prevention studies: A systematic review. Am J Clin Nutr 2006; 84: 5-17.
6. Iso H, Kobayashi M, Ishihara J, Sasaki S, Okada K, Kita Y, et al; JPHC Study Group. Intake of fish and n3 fatty acids and risk of coronary heart disease among Japanese: The Japan Public Health Center- Based (JPHC) Study Cohort I. Circulation 2006; 113: 195-202.
7. Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Saito Y, Ishikawa Y, et al; Japan EPA Lipid Intervention Study (JELIS) Investigators. Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): A randomised open-label, blinded endpoint analysis. Lancet 2007; 369: 1090-1098.
8. Marchioli R, Barzi F, Bomba E, Chieffo C, Di Gregorio D, Di Mascio R, et al; GISSI-Prevenzione Investigators. Early protection against sudden death by n-3 polyunsaturated fatty acids after myocardial infarction: Time-course analysis of the results of the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)- Prevenzione. Circulation 2002; 105: 1897-1903.
9. Gissi-HF Investigators, Tavazzi L, Maggioni AP, Marchioli R, Barlera S, Franzosi MG, Latini R, et al. Effect of n-3 polyunsaturated fatty acids in patients with chronic heart failure (the GISSI-HF trial): A randomised, double-blind, placebo-controlled trial. Lancet 2008; 372: 1223-1230.
10. Nodari S, Triggiani M, Campia U, Manerba A, Milesi G, Cesana BM, et al. Effects of n-3 polyunsaturated fatty acids on left ventricular function and functional capacity in patients with dilated cardiomyopathy. J Am Coll Cardiol 2011; 57: 870-879.
11. Mozaffarian D, Lemaitre RN, King IB, Song X, Spiegelman D, Sacks FM, et al. Circulating long-chain ω-3 fatty acids and incidence of congestive heart failure in older adults: The cardiovascular health study: A cohort study. Ann Intern Med 2011; 155: 160-170.
12. Nakatani D, Sakata Y, Mizuno H, Shimizu M, Suna S, Usami M, et al; Osaka Acute Coronary Insufficiency Study (OACIS) Group. Impact of diabetes mellitus on rehospitalization for heart failure among survivors of acute myocardial infarction in the percutaneous coronary intervention era. Circ J 2009; 73: 662-666.
13. Shiozaki M, Iso H, Ohira T, Nakatani D, Shimizu M, Sakata Y, et al. Longitudinal risk of cardiovascular events in relation to depression symptoms after discharge among survivors of myocardial infarction: Osaka Acute Coronary Insufficiency Study. Circ J 2011; 75: 2878-2884.
14. Rosenbaum PR, Rubin DB. Reducing bias in observational studies using subclassification on the propensity score. J Am Stat Assoc 1984; 79: 516-524.
15. Peoples GE, McLennan PL, Howe PR, Groeller H. Fish oil reduces heart rate and oxygen consumption during exercise. J Cardiovasc Pharmacol 2008; 52: 540-547.
16. Ghio S, Scelsi L, Latini R, Masson S, Eleuteri E, Palvarini M, et al; GISSI-HF investigators. Effects of n-3 polyunsaturated fatty acids and of rosuvastatin on left ventricular function in chronic heart failure: A substudy of GISSI-HF trial. Eur J Heart Fail 2010; 12: 1345-1353.
17. Geleijnse JM, Giltay EJ, Grobbee DE, Donders AR, Kok FJ. Blood pressure response to fish oil supplementation: Metaregression analysis of randomized trials. J Hypertens 2002; 20: 1493-1499.
18. Mozaffarian D, Geelen A, Brouwer IA, Geleijnse JM, Zock PL, Katan MB. Effect of fish oil on heart rate in humans: A meta-analysis of randomized controlled trials. Circulation 2005; 112: 1945-1952.
19. Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: Evaluating the risks and the benefits. JAMA 2006; 296: 1885-1899.
20. Saito Y, Yokoyama M, Origasa H, Matsuzaki M, Matsuzawa Y, Ishikawa Y, et al; JELIS Investigators, Japan. Effects of EPA on coronary artery disease in hypercholesterolemic patients with multiple risk factors: Sub-analysis of primary prevention cases from the Japan EPA Lipid Intervention Study (JELIS). Atherosclerosis 2008; 200: 135-140.
21. Domei T, Yokoi H, Kuramitsu S, Soga Y, Arita T, Ando K, et al. Ratio of serum n-3 to n-6 polyunsaturated fatty acids and the incidence of major adverse cardiac events in patients undergoing percutaneous coronary intervention. Circ J 2012; 76: 423-429.
22. Kris-Etherton PM, Harris WS, Appel LJ; AHA Nutrition Committee. American Heart Association. Omega-3 fatty acids and cardiovascular disease: New recommendations from the American Heart Association. Arterioscler Thromb Vasc Biol 2003; 23: 151-152.