Transforming Growth Factor-β, Macrophage Colony-Stimulating Factor and C-Reactive Protein Levels Correlate with CD14highCD16+ Monocyte Induction and Activation in Trauma Patients

PLoS ONE

Volumn 7, Issue 12, 2012, Pages

  West, Sonlee D ^a   Goldberg, Daniel ^a   Ziegler, Anna ^a   Krencicki, Michael ^a   du Clos, Terry W ^a   Mold, Carolyn ^a  

^a UNIVERSITY OF NEW MEXICO HEALTH SCIENCES CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CD14 ANTIGEN; CD16 ANTIGEN; CD163 ANTIGEN; COLONY STIMULATING FACTOR 1; GAMMA INTERFERON; HEME OXYGENASE 1; HLA DR ANTIGEN; INTERLEUKIN 1 RECEPTOR TYPE I; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MONOCYTE CHEMOTACTIC PROTEIN 1; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ANTIGEN EXPRESSION; ARTICLE; BLOOD SAMPLING; CELL ACTIVATION; CELL DIFFERENTIATION; CELL SUBPOPULATION; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE DYSREGULATION; INJURY; INJURY SCALE; INJURY SEVERITY; MALE; MONOCYTE; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PHENOTYPE; WOUND HEALING;

ADOLESCENT; ADULT; AGED; ANTIGENS, CD14; C-REACTIVE PROTEIN; CASE-CONTROL STUDIES; FEMALE; FLOW CYTOMETRY; HEME OXYGENASE-1; HUMANS; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MIDDLE AGED; MONOCYTES; RECEPTORS, IGG; STATISTICS, NONPARAMETRIC; TRANSFORMING GROWTH FACTOR BETA; TREATMENT OUTCOME; WOUNDS AND INJURIES; YOUNG ADULT;

EID: 84871677303     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0052406     Document Type: Article

References (38)

1. Martin C, Boisson C, Haccoun M, Thomachot L, Mege JL, (1997) Patterns of cytokine evolution (tumor necrosis factor-alpha and interleukin-6) after septic shock, hemorrhagic shock and severe trauma. Crit Care Med 25: 1813-1819.
2. Keel M, Trentz O, (2005) Pathophysiology of polytrauma. Injury 36: 691-709.
3. Mokart D, Capo C, Blache JL, Delpero JR, Houvenaeghel G, et al. (2002) Early post-operative compensatory anti-inflammatory response syndrome is associated with septic complications after major surgical trauma in patients with cancer. Br J Surg 89: 1450-1456.
4. Xiao W, Mindrinos MN, Seok J, Cuschieri J, Cuenca AG, et al. (2011) A genomic storm in crtically injured humans. J Exp Med 208: 2581-2590.
5. Oberholzer A, Oberholzer C, Moldawer LL, (2001) Sepsis syndromes: understanding the role of innate and acquired immunity. SHOCK 16: 83-96.
6. Kumpf O, Schumann RR, (2010) Genetic variation in innate immunity pathways and their potential contribution to the SIRS/CARS debate: evidence from human studies and animal models. J Innate Immun 2: 381-394.
7. Cohen J, (2002) The immunopathogenesis of sepsis. Nature 420: 885-891.
8. Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, et al. (2010) Nomenclature of monocytes and dendritic cells in blood. Blood 116: e74-80.
9. Geissmann F, Manz MG, Jung S, Sieweke MH, Merad M, Ley K, (2010) Development of monocytes, macrophages and dendritic cells. Science 327: 656-661.
10. Lekkou A, Karakantza M, Mouzaki A, Kalfarentzos F, Gogos CA, (2004) Cytokine production and monocyte HLA-DR expression as predictors of outcome for patients with community-acquired severe infections. Clin Diag Lab Immunol. 11: 161-167.
11. Skrzeczynska-Moncznik J, Bzowska M, Loseke S, Grage-Griebenow E, Zembala M, et al. (2008) Peripheral blood CD14highCD16+ monocytes are main producers of IL-10. Scan J Immunol 67: 152-159.
12. Belge KU, Dayyani F, Horelt A, Siedlar M, Frankenberger M, et al. (2002) The pro-inflammatory CD14+CD16+DR++ monocytes are a moajor source of TNF. J Immunol 168: 3536-3542.
13. Ziegler-Heitbrock L, (2007) The CD14+CD16+ blood monocytes: their role in infection and inflammation. J Leukoc Biol 81: 584-592.
14. Skrzeczynska J, Kobylarz K, Hartwich Z, Zembala M, Pryjma J, (2002) CD14+CD16+ monocytes in the course of sepsis in neonates and small children: monitoring and functional studies. Scand J Immunol 55: 629-638.
15. Colo Brunialti MK, Santos MC, Rigato O, Machado FR, Silva E, et al. (2012) Increased percentages of T helper cells producing IL-17 and monocytes expressing markers of alternative activation in patients with sepsis. PLoS One 7: e37393.
16. Buechler C, Ritter M, Orso E, Langmann T, Klucken J, et al. (2000) Regulation of scavenger receptor CD163 expression in human monocytes and macrophages by pro- and anti-inflammatory stimuli. J Leukoc Biol 67: 91-103.
17. Philippidis P, Mason JC, Evans BJ, Nadra I, Taylor KM, et al. (2004) Hemoglobin scavenger receptor CD163 mediates Interleukin-10 release and heme oxygenase-1 synthesis. Circ Res 94: 119-126.
18. Roach JP, Moore EE, Partrick DA, Damle SS, Silliman CC, et al. (2009) Heme-oxygenase-1 induction in macrophages by a hemoglobin-based oxygen carrier reduces endotoxin-stimulated cytokine secretion. SHOCK 31: 251-257.
19. Van Gorp H, Delputte PL, Nauwynck HJ, (2010) Scavenger receptor CD163, a Jack-of-all-trades and potential target for cell-directed therapy. Mol Immunol 47: 1650-1660.
20. West SD, Mold C, (2012) Monocyte deactivation correlates with Injury Severity Score, but not with heme oxygenase-1 levels in trauma patients. J Surg Res 172: 5-10.
21. Laping NJ, Grygielko E, Mathur A, Butter S, Bomberger J, et al. (2002) Inhibition of transforming growth factor (TGF)-β1-induced extracellular matrix with a novel inhibitor of the TGF-β type 1 receptor kinase activity: SB-431542. Mol Pharmacol 62: 58-64.
22. Ohno H, Kubo K, Murooka H, Kobayashi Y, Nishitoba T, et al. (2006) A c-fms tyrosine kinase inhibitor, Ki20227, suppresses osteoclast differentiation and osteolytic bone destruction in a bone metastasis model. Mol Cancer Ther 5: 2634-2643.
23. Munn DH, Bree AG, Beall AC, Kaviani MD, Sabio H, et al. (1996) Recombinant human macrophage colony-stimulating factor in nonhuman primates: selective expansion of a CD16+ monocyte subset with phenotypic similarity to natural killer cells. Blood 88: 1215-1224.
24. Ambarus CA, Krausz S, van Eijk M, Hamann J, Radstake TRDJ, et al. (2012) Systematic validation of specific phenotypic markers for in vitro polarized human macrophages. J Immunol Methods 375: 196-206.
25. Kampalath B, Cleveland RP, Chang CC, Kass L, (2003) Monocytes with altered phenotypes in posttrauma patients. Arch Pathol Lab Med 127: 1580-1585.
26. Feng AL, Zhu JK, Sun JT, Yang MX, Neckenig MR, et al. (2011) CD16+ monocytes in breast cancer patients: expanded by monocyte chemoattractant protein-1 and may be useful for early diagnosis. Clin Exp Immunol 164: 57-65.
27. Moniuszko M, Bodzenta-Lukaszyk A, Kowal K, Lenczewska D, Dabrowska M, (2009) Enhanced frequencies of CD14++CD16+, but not CD14+CD16+, peripheral blood monocytes in severe asthmatic patients. Clin Immunol 130: 338-346.
28. Zhang JY, Zou ZS, Huang A, Zhang Z, Fu JL, et al. (2011) Hyper-activated pro-inflammatory CD16+ monocytes correlate with severity of liver injury and fibrosis in patients with chronic hepatitis B. PLoS One. 6: e17484.
29. Mosser DM, Edwards JP, (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969.
30. Martinez FO, Sica A, Mantovani A, Locati M, (2008) Macrophage activation and polarization. Front Biosci 13: 453-461.
31. Welch GR, Wong HL, Wahl SM, (1990) Selective induction of Fc gamma RIII on human monocytes by transforming growth factor-beta. J Immunol. 144: 3444-3448.
32. De AK, Laudanski K, Miller-Graziano CLM, (2003) Failure of monocytes of trauma patients to convert to immature dendritic cells is related to preferential macrophage-colong stimulating factor-driven macrophage differentiation. J Immunol. 170: 6355-6362.
33. Chen Y, Kam CSK, Liu FQ, Liu Y, Lui VCH, et al. (2008) LPS-induced up-regulation of TGF-β receptor 1 is associated with TNF-α expression in human monocyte-derived macrophages. J Leuk Biol 83: 1165-1173.
34. Devaraj S, Yun JM, Duncan-Staley C, Jialal I, (2009) C-reactive protein induces M-CSF release and macrophage proliferation. J Leukoc Biol 85: 262-267.
35. Lobo SM, Lobo FR, Bota DP, Lopes-Ferreira F, Soliman HM, et al. (2003) C-reactive protein levels correlate with mortality and organ failure in critically ill patients. Chest 123: 2043-2049.
36. Lu J, Marnell LL, Marjon KD, Mold C, Du Clos TW, et al. (2008) Structural recognition and functional activation of FcγR by innate pentraxins. Nature 456: 989.
37. Mold C, Rodriguez W, Rodic-Polic B, Du Clos TW, (2002) C-reactive protein mediates protection from lipopolysaccharide through interactions with Fc gamma R. J Immunol. 169: 7019-7025.
38. Sutterwala FS, Noel GJ, Salgame P, Mosser DM, (1998) Reversal of proinflammatory responses by ligating the macrophage Fcγ receptor type I. J Exp Med. 188: 217-222.