Distribution and levels of alpha-1-antitrypsin in the lung and plasma in smokers and chronic obstructive pulmonary disease

APMIS

Volumn 121, Issue 1, 2013, Pages 11-21

  Linja Aho, Anna ^a   Mazur, Witold ^a   Toljamo, Tuula ^b   Nieminen, Pentti ^c   Ohlmeier, Steffen ^c   Rönty, Mikko ^a   Kinnula, Vuokko L ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b LAPLAND CENTRAL HOSPITAL   (Finland)

^c UNIVERSITY OF OULU   (Finland)

Author keywords

Alpha 1 antitrypsin; Chronic obstructive pulmonary disease; Proteomics; SerpinA1; Smoking

Indexed keywords

ALPHA 1 ANTITRYPSIN;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL ARTICLE; DISEASE CLASSIFICATION; FEMALE; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; LUNG ALVEOLUS EPITHELIUM; MALE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SMOKING; SMOKING CESSATION; SPUTUM;

AGED; ALPHA 1-ANTITRYPSIN; BLOTTING, WESTERN; COHORT STUDIES; CROSS-SECTIONAL STUDIES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; IMMUNOHISTOCHEMISTRY; LUNG; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SMOKING; SPUTUM; STATISTICS, NONPARAMETRIC;

EID: 84871668363     PISSN: 09034641     EISSN: 16000463     Source Type: Journal    
DOI: 10.1111/j.1600-0463.2012.02936.x     Document Type: Article

References (50)

1. Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM. Global burden of COPD: systematic review and meta-analysis. Eur Respir J 2006;28:523-32.
2. Lopez AD, Mathers CD. Measuring the global burden of disease and epidemiological transitions: 2002-2030. Ann Trop Med Parasitol 2006;100:481-99.
3. Gan WQ, Man SF, Senthilselvan A, Sin DD. Association between chronic obstructive pulmonary disease and systemic inflammation: a systematic review and a meta-analysis. Thorax 2004;59:574-80.
4. Gosselink JV, Hayashi S, Elliott WM, Xing L, Chan B, Yang L, et al. Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;181:1329-35.
5. RytiläP, Rehn T, Ilumets H, Rouhos A, Sovijärvi A, Myllärniemi M, et al. Increased oxidative stress in asymptomatic current chronic smokers and GOLD stage 0 COPD. Respir Res 2006;7:69.
6. Ilumets H, RytiläP, Demedts I, Brusselle GG, Sovijärvi A, Myllärniemi M, et al. Matrix metalloproteinases -8, -9 and -12 in smokers and patients with stage 0 COPD. Int J Chron Obstruct Pulmon Dis 2007;2:369-79.
7. Kinnula VL, Ilumets H, Myllärniemi M, Sovijärvi A, RytiläP. 8-Isoprostane as a marker of oxidative stress in nonsymptomatic cigarette smokers and COPD. Eur Respir J 2007;29:51-5.
8. Kinnula VL. Focus on antioxidant enzymes and antioxidant strategies in smoking related airway diseases. Thorax 2005;60:693-700.
9. Ohlmeier S, Mazur W, Linja-Aho A, Louhelainen N, Rönty M, Toljamo T, et al. Sputum proteomics identifies elevated PIGR levels in smokers and mild-to-moderate COPD. J Proteome Res 2012;11:599-608.
10. Janciauskiene SM, Bals R, Koczulla R, Vogelmeier C, Kohnlein T, Welte T. The discovery of alpha1-antitrypsin and its role in health and disease. Respir Med 2011;105:1129-39.
11. Nishioka T, Uchida K, Meno K, Ishii T, Aoki T, Imada Y, et al. Alpha-1-antitrypsin and complement component C7 are involved in asthma exacerbation. Proteomics Clin Appl 2008;2:46- 54.
12. Engstrom G, Segelstorm N, Ekberg-Aronsson M, Nilsson PM, Lindgarde F, Lofdahl CG. Plasma markers of inflammation and incidence of hospitalisations for COPD: results from a population-based cohort study. Thorax 2009; 64:211-5.
13. Koczulla AR, Noeske S, Herr C, Koepke J, Jorres RA, Nell C, et al. Alpha-1 antitrypsin is elevated in exhaled breath condensate and serum in exacerbated COPD patients. Respir Med 2012;106:120-6.
14. du Bois RM, Bernaudin JF, PääkköP, Hubbard R, Takahashi H, Ferrans V, et al. Human neutrophils express the alpha 1-antitrypsin gene and produce alpha 1-antitrypsin. Blood 1991; 77:2724-30.
15. Perlmutter DH, Cole FS, Kilbridge P, Rossing TH, Colten HR. Expression of the alpha 1-proteinase inhibitor gene in human monocytes and macrophages. Proc Natl Acad Sci USA 1985;82:795-9.
16. Venembre P, Boutten A, Seta N, Dehoux MS, Crestani B, Aubier M, et al. Secretion of alpha 1-antitrypsin by alveolar epithelial cells. FEBS Lett 1994;346:171-4.
17. Cichy J, Potempa J, Travis J. Biosynthesis of alpha1-proteinase inhibitor by human lungderived epithelial cells. J Biol Chem 1997; 272:8250-5.
18. Aldonyte R, Hutchinson TE, Jin B, Brantly M, Block E, Patel J, et al. Endothelial alpha-1-antitrypsin attenuates cigarette smoke induced apoptosis in vitro. COPD 2008;5:153-62.
19. Sohrab S, Petrusca DN, Lockett AD, Schweitzer KS, Rush NI, Gu Y, et al. Mechanism of alpha-1 antitrypsin endocytosis by lung endothelium. FASEB J 2009;23:3149-58.
20. Tuder RM, Janciauskiene SM, Petrache I. Lung disease associated with alpha1-antitrypsin deficiency. Proc Am Thorac Soc 2010;7:381-6.
21. Quint JK, Donaldson GC, Kumari M, Talmud PJ, Hurst JR. SERPINA1 11478G?A variant, serum alpha1-antitrypsin, exacerbation frequency and FEV1 decline in COPD. Thorax 2011;66:418-24.
22. Dahl M, Nordestgaard BG. Markers of early disease and prognosis in COPD. Int J Chron Obstruct Pulmon Dis 2009;4:157-67.
23. Burnett D, Stockley RA. The electrophoretic mobility of alpha 1-antitrypsin in sputum and its relationship to protease inhibitory capacity, leucocyte elastase concentrations and acute respiratory infection. Hoppe Seylers Z Physiol Chem 1980;361:781-9.
24. Stockley RA, Bayley D, Hill SL, Hill AT, Crooks S, Campbell EJ. Assessment of airway neutrophils by sputum colour: correlation with airways inflammation. Thorax 2001;56:366-72.
25. Stockley RA, Bayley DL, Unsal I, Dowson LJ. The effect of augmentation therapy on bronchial inflammation in alpha1-antitrypsin deficiency. Am J Respir Crit Care Med 2002;165:1494-8.
26. Vignola AM, Bonanno A, Mirabella A, Riccobono L, Mirabella F, Profita M, et al. Increased levels of elastase and alpha1-antitrypsin in sputum of asthmatic patients. Am J Respir Crit Care Med 1998;157:505-11.
27. Afford SC, Burnett D, Campbell EJ, Cury JD, Stockley RA. The assessment of alpha 1 proteinase inhibitor form and function in lung lavage fluid from healthy subjects. Biol Chem Hoppe Seyler 1988;369:1065-74.
28. Olsen GN, Harris JO, Castle JR, Waldman RH, Karmgard HJ. Alpha-1-antitrypsin content in the serum, alveolar macrophages, and alveolar lavage fluid of smoking and nonsmoking normal subjects. J Clin Invest 1975;55:427-30.
29. Wewers MD, Herzyk DJ, Gadek JE. Comparison of smoker and nonsmoker lavage fluid for the rate of association with neutrophil elastase. Am J Respir Cell Mol Biol 1989;1:423-9.
30. Toljamo T, Kaukonen M, Nieminen P, Kinnula VL. Early detection of COPD combined with individualized counselling for smoking cessation: a two-year prospective study. Scand J Prim Health Care 2010;28:41-6.
31. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 2007;176:532-55.
32. Viljanen AA, Halttunen PK, Kreus KE, Viljanen BC. Spirometric studies in non-smoking, healthy adults. Scand J Clin Lab Invest Suppl 1982;159:5-20.
33. Ohlmeier S, Mazur W, Salmenkivi K, Myllärniemi M, Bergmann U, Kinnula VL. Proteomic studies on receptor for advanced glycation end product variants in idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease. Proteomics Clin Appl 2010;4:97-105.
34. Ishikawa N, Ohlmeier S, Salmenkivi K, Myllärniemi M, Rahman I, Mazur W, et al. Hemoglobin alpha and beta are ubiquitous in the human lung, decline in idiopathic pulmonary fibrosis but not in COPD. Respir Res 2010;11:123.
35. Efthimiadis A, Spanevello A, Hamid Q, Kelly MM, Linden M, Louis R, et al. Methods of sputum processing for cell counts, immunocytochemistry and in situ hybridisation. Eur Respir J Suppl 2002;37:19s-23s.
36. Ohlmeier S, Vuolanto M, Toljamo T, Vuopala K, Salmenkivi K, Myllärniemi M, et al. Proteomics of human lung tissue identifies surfactant protein A as a marker of chronic obstructive pulmonary disease. J Proteome Res 2008;7:5125-32.
37. Casado B, Iadarola P, Pannell LK, Luisetti M, Corsico A, Ansaldo E, et al. Protein expression in sputum of smokers and chronic obstructive pulmonary disease patients: a pilot study by CapLC-ESI-Q-TOF. J Proteome Res 2007; 6:4615-23.
38. Glare EM, Divjak M, Bailey MJ, Walters EH. beta-Actin and GAPDH housekeeping gene expression in asthmatic airways is variable and not suitable for normalising mRNA levels. Thorax 2002;57:765-70.
39. Ishii T, Wallace AM, Zhang X, Gosselink J, Abboud RT, English JC, et al. Stability of housekeeping genes in alveolar macrophages from COPD patients. Eur Respir J 2006;27:300-6.
40. Boutten A, Venembre P, Seta N, Hamelin J, Aubier M, Durand G, et al. Oncostatin M is a potent stimulator of alpha1-antitrypsin secretion in lung epithelial cells: modulation by transforming growth factor-beta and interferon-gamma. Am J Respir Cell Mol Biol 1998;18:511-20.
41. Senn O, Russi EW, Schindler C, Imboden M, von EA, Brandli O, et al. Circulating alpha1- antitrypsin in the general population: determinants and association with lung function. Respir Res 2008;9:35.
42. Janoff A, Carp H. Possible mechanisms of emphysema in smokers: cigarette smoke condensate suppresses protease inhibition in vitro. Am Rev Respir Dis 1977;116:65-72.
43. Evans MD, Church DF, Pryor WA. Aqueous cigarette tar extracts damage human alpha-1- proteinase inhibitor. Chem Biol Interact 1991;79:151-64.
44. Gazzani G, Fregnan GB, Vandoni G. In vitro protection by erdosteine against oxidative inactivation of alpha-1-antitrypsin by cigarette smoke. Respiration 1989;55:113-8.
45. Hubbard RC, Ogushi F, Fells GA, Cantin AM, Jallat S, Courtney M, et al. Oxidants spontaneously released by alveolar macrophages of cigarette smokers can inactivate the active site of alpha 1-antitrypsin, rendering it ineffective as an inhibitor of neutrophil elastase. J Clin Invest 1987;80:1289-95.
46. Nicholas B, Skipp P, Mould R, Rennard S, Davies DE, O'Connor CD, et al. Shotgun proteomic analysis of human-induced sputum. Proteomics 2006;6:4390-401.
47. Nicholas BL, Skipp P, Barton S, Singh D, Bagmane D, Mould R, et al. Identification of lipocalin and apolipoprotein A1 as biomarkers of chronic obstructive pulmonary disease. Am J Respir Crit Care Med 2010;181:1049-60.
48. Baumann H, Gauldie J. The acute phase response. Immunol Today 1994;15:74-80.
49. Bridges RB, Wyatt RJ, Rehm SR. Effect of smoking on peripheral blood leukocytes and serum antiproteases. Eur J Respir Dis Suppl 1985;139:24-33.
50. van Antwerpen V, Theron AJ, Richards GA, Steenkamp KJ, van der Merwe CA, van der Walt R, et al. Vitamin E, pulmonary functions, and phagocyte-mediated oxidative stress in smokers and nonsmokers. Free Radic Biol Med 1995;18:935-41.