An inactivated Pseudomonas aeruginosa medicament inhibits airway allergic inflammation and improves epithelial functions

Journal of Physiological Sciences

Volumn 63, Issue 1, 2013, Pages 63-69

  Tan, Yurong ^a   Liu, Huijun ^a   Yang, Huihui ^a   Wang, Lili ^a   Qin, Xiaoqun ^a  

^a Central South University   (China)

Author keywords

Airway hyperresponsiveness; Pseudomonas aeruginosa; Th2 cytokines; Toll like receptors

Indexed keywords

ACT1 PROTEIN; CONNEXIN 43; DNA BINDING PROTEIN; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 17; INTERLEUKIN 4; LOC683206 PROTEIN, RAT; PEPTIDE FRAGMENT; TOLL LIKE RECEPTOR;

AIRWAY RESISTANCE; ANIMAL; ARTICLE; BRONCHUS; BRONCHUS HYPERREACTIVITY; CELL CULTURE; CELL GROWTH; GENETIC TRANSFECTION; GENETICS; HUMAN; METABOLISM; MICROBIOLOGY; PATHOLOGY; PHYSIOLOGY; PSEUDOMONAS AERUGINOSA; RAT; RESPIRATORY TRACT MUCOSA; SPRAGUE DAWLEY RAT; TH17 CELL;

AIRWAY RESISTANCE; ANIMALS; BRONCHI; BRONCHIAL HYPERREACTIVITY; CELL GROWTH PROCESSES; CELLS, CULTURED; CONNEXIN 43; DNA-BINDING PROTEINS; HUMANS; INTERFERON-GAMMA; INTERLEUKIN-17; INTERLEUKIN-4; NF-KAPPA B; PEPTIDE FRAGMENTS; PSEUDOMONAS AERUGINOSA; RATS; RATS, SPRAGUE-DAWLEY; RESPIRATORY MUCOSA; TH17 CELLS; TOLL-LIKE RECEPTORS; TRANSFECTION;

EID: 84871667475     PISSN: 18806546     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12576-012-0231-x     Document Type: Article

References (16)

1. Velasco G, Campo M, Manrique OJ, Bellou A, He H, Arestides RS, Schaub B, Perkins DL, Finn PW (2005) Toll-like receptor 4 or 2 agonists decrease allergic inflammation. Am J Respir Cell Mol Biol 32:218-224 (Pubitemid 40387648)
2. Inoue K, Takano H, Yanagisawa R, Hirano S, Ichinose T, Shimada A, Yoshikawa T (2006) The role of toll-like receptor 4 in airway inflammation induced by diesel exhaust particles. Arch Toxicol 80:275-279
3. Williams AS, Leung SY, Nath P, Khorasani NM, Bhavsar P, Issa R, Mitchell JA, Adcock IM, Chung KF (2007) Role of TLR2, TLR4, and MyD88 in murine ozone-induced airway hyperresponsiveness and neutrophilia. J Appl Physiol 103:1189-1195 (Pubitemid 47610420)
4. Wassef A, Janardhan K, Pearce JW, Singh B (2004) Toll-like receptor 4 in normal and inflamed lungs and other organs of pig, dog and cattle. Histol Histopathol 19:1201-1208 (Pubitemid 39386778)
5. Shaykhiev R, Behr J, Bals R (2008) Microbial patterns signaling via Toll-like receptors 2 and 5 contribute to epithelial repair, growth and survival. PLoS ONE 3:e1393 (Pubitemid 351210957)
6. John G, Chillappagari S, Rubin BK, Gruenert DC, Henke MO (2011) Reduced surface toll-like receptor-4 expression and absent interferon-γ-inducible protein-10 induction in cystic fibrosis airway cells. Exp Lung Res 37:319-326
7. Grissell TV, Chang AB, Gibson PG (2007) Reduced toll-like receptor 4 and substance P gene expression is associated with airway bacterial colonization in children. Pediatr Pulmonol 42:380-385 (Pubitemid 46608909)
8. Ashkar AA, Mossman KL, Coombes BK, Gyles CL, Mackenzie R (2008) FimH adhesion of type 1 fimbriae is a potent inducer of innate antimicrobial responses which requires TLR4 and type 1 interferon signaling. PLoS Pathog 4:e1000233
9. da Silva Correia J, Ulevitch RJ (2002) MD-2 and TLR4 N-linked glycosylations are important for a functional lipopolysaccharide receptor. J Biol Chem 277:1845-1854 (Pubitemid 34968758)
10. Ren YH, Qin XQ, Guan CX, Luo ZQ, Zhang CQ, Sun XH (2004) Temporal and spatial distribution of VIP, CGRP and their receptors in the development of airway hyperresponsiveness in the lungs. Sheng Li Xue Bao 56:137-146
11. Duechs MJ, Hahn C, Benediktus E, Werner-Klein M, Braun A, Hoymann HG, Gantner F, Erb KJ (2011) TLR agonist mediated suppression of allergic responses is associated with increased innate inflammation in the airways. Pulm Pharmacol Ther 24:203-214
12. Claudio E, Sønder SU, Saret S, Carvalho G, Ramalingam TR, Wynn TA, Chariot A, Garcia-Perganeda A, Leonardi A, Paun A, Chen A, Ren NY, Wang H, Siebenlist U (2009) The adaptor protein CIKS/Act1 is essential for IL-25-mediated allergic airway inflammation. J Immunol 182:1617-1630
13. Qian Y, Qin J, Cui G, Naramura M, Snow EC, Ware CF, Fairchild RL, Omori SA, Rickert RC, Scott M, Kotzin BL, Li X (2004) Act1, a negative regulator in CD40- and BAFF-mediated B cell survival. Immunity 21:575-587 (Pubitemid 39370512)
14. Swaidani S, Bulek K, Kang Z, Liu C, Lu Y, Yin W, Aronica M, Li X (2009) The critical role of epithelial-derived Act1 in IL-17- and L-25-mediated pulmonary inflammation. J Immunol 182:1631-1640
15. Kang NI, Yoon HY, Lee YR, Won M, Chung MJ, Park JW, Hur GM, Lee HK, Park BH (2009) A20 attenuates allergic airway inflammation in mice. J Immunol 183:488-495
16. Martin C, Thévenot G, Danel S, Chapron J, Tazi A, Macey J, Dusser DJ, Fajac I, Burgel PR (2011) Pseudomonas aeruginosa induces vascular endothelial growth factor synthesis in airway epithelium in vitro and in vivo. Eur Respir J 38:939-946