A chronocoulometric LNA sensor for amplified detection of K-ras mutation based on site-specific DNA cleavage of restriction endonuclease

Biosensors and Bioelectronics

Volumn 42, Issue 1, 2013, Pages 409-414

  Lin, Liqing ^a   Liu, Ailin ^a   Zhao, Chengfei ^a   Weng, Shaohuang ^a   Lei, Yun ^a   Liu, Qicai ^a   Lin, Xinhua ^a   Chen, Yuanzhong ^a  

^a FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Chronocoulometric LNA sensor; K ras mutation; RuHex; Site specific DNA cleavage

Indexed keywords

DETECTION LIMITS; DNA CLEAVAGE; DNA CONCENTRATION; ELECTROCHEMICAL DETECTION; ELECTROCHEMICAL SIGNALS; ENZYMATIC CLEAVAGE; GOLD ELECTRODES; GOLD NANOPARTICLES; K-RAS MUTATION; LINEAR RELATIONSHIPS; LOCKED NUCLEIC ACID; LOGARITHMIC FUNCTIONS; PANCREATIC CANCERS; POINT MUTATIONS; RESTRICTION ENDONUCLEASES; RUHEX; SITE-SPECIFIC; WILD TYPES;

BIOSENSORS; CHLORINE COMPOUNDS; DNA; GOLD; PROBES; SENSORS;

LOW NOISE AMPLIFIERS;

GOLD NANOPARTICLE; RESTRICTION ENDONUCLEASE;

ARTICLE; BIOSENSOR; DNA CLEAVAGE; DNA STRAND; ELECTROCHEMICAL ANALYSIS; GENE IDENTIFICATION; GENE MUTATION; LIMIT OF DETECTION; MOLECULAR PATHOLOGY; MUTATIONAL ANALYSIS; NANOANALYSIS; ONCOGENE K RAS; OXIDATION REDUCTION STATE; PANCREAS CANCER; POINT MUTATION; POLYMERASE CHAIN REACTION; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; SENSITIVITY ANALYSIS; SINGLE NUCLEOTIDE POLYMORPHISM; STATIC ELECTRICITY;

BIOSENSING TECHNIQUES; DNA CLEAVAGE; ELECTROCHEMICAL TECHNIQUES; GOLD; HUMANS; LIMIT OF DETECTION; METAL NANOPARTICLES; PANCREATIC NEOPLASMS; POINT MUTATION; RAS PROTEINS;

EID: 84871667095     PISSN: 09565663     EISSN: 18734235     Source Type: Journal    
DOI: 10.1016/j.bios.2012.09.063     Document Type: Article

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