Differentiation of chronic pancreatitis from pancreatic cancer: Recent advances in molecular diagnosis

Digestive Diseases

Volumn 19, Issue 1, 2001, Pages 32-36

  Ebert, Matthias ^a   Schandl, Laslo ^a   Schmid, Roland M ^b  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

^b UNIVERSITY OF ULM   (Germany)

Author keywords

Gene; Pancreas; Screening

Indexed keywords

BIOCHEMICAL MARKER;

CHRONIC PANCREATITIS; DIFFERENTIAL DIAGNOSIS; DISEASE ASSOCIATION; GENETIC MARKER; MOLECULAR BIOLOGY; PANCREAS CANCER; PANCREAS FUNCTION; PANCREAS ISLET CELL FUNCTION; PATHOGENESIS; PRIORITY JOURNAL; REVIEW;

ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHRONIC DISEASE; DIAGNOSIS, DIFFERENTIAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GROWTH SUBSTANCES; HUMANS; PANCREATIC NEOPLASMS; PANCREATITIS; TUMOR MARKERS, BIOLOGICAL;

EID: 0034980388     PISSN: 02572753     EISSN: None     Source Type: Journal    
DOI: 10.1159/000050651     Document Type: Review

References (63)

1. Pancreas
2. Fibroblast structure and function during regeneration from hormone-induced acute pancreatitis in the rat
3. Expression of major histocompatibility antigens in human chronic pancreatitis
4. CD8+CD103+ T cells analogous to intestinal intraepithelial lymphocytes infiltrate the pancreas in chronic pancreatitis
5. T cell-mediated exocrine pancreatic damage in major histocompatibility complex class II-deficient mice
6. Differential expression of chemokines in normal pancreas and in chronic pancreatitis
7. Cytotoxic cells are activated in cellular infiltrates of alcoholic chronic pancreatitis
8. Immune cell infiltration and growth-associated protein 43 expression correlate with pain in chronic pancreatitis
9. Oncostatin M stimulates excessive extracellular matrix accumulation in a transgenic mouse model of connective tissue disease
10. Islet inflammation and hyper-plasia induced by the pancreatic islet-specific overexpression of interleukin-6 in transgenic mice
11. Chronic pancreatitis
12. Pathogenesis of chronic pancreatitis
13. Chronic pancreatitis
14. Secretory pancreatic stone protein messenger RNA: Nucleotide sequence and expression in chronic calcifying pancreatitis
15. Chronic pancreatitis: Still puzzling?
16. Hereditary pancreatitis: New insights into acute and chronic pancreatitis
17. Mutations of the cystic fibrosis gene in patients with chronic pancreatitis
18. Induction and expression of amphiregulin in human pancreatic cancer
19. Coexpression of the c-met protoonco-gene and hepatocyte growth factor in human pancreatic cancer
20. Induction of platelet-derived growth factor A and B chains and over-expression of their receptors in human pancreatic cancer
21. Localisation of transforming growth factor β1 and its latent binding protein in human chronic pancreatitis
22. Transforming growth factor (TGF-β1) promotes development of fibrosis after repeated courses of acute pancreatitis
23. Extracellular matrix is reduced by inhibition of transforming growth factor β1 in pancreatitis in the rat
24. Accumulation of extracellular matrix and developmental dysregulation in the pancreas by transgenic production of transforming growth factor β1
25. Pancreatic stellate cells are activated by proinflammatory cytokines: Implications for pancreatic fibrinogenesis
26. Platelet-derived growth factors stimulate proliferation and extracellular matrix synthesis of pancreatic stellate cells: Implications in pathogenesis of pancreatic fibrosis
27. Overexpression of TGF-alpha in transgenic mice: Induction of epithelial hyperplasia, pancreatic metaplasia and carcinoma of the breast
28. Malignant transformation of duct-like cells originating from acini in transforming growth factor alpha transgenic mice
29. Genetic progression in the pancreatic ducts
30. The link between exocrine pancreatic cancer and the endocrine pancreas
31. Differentiation of pancreatic acinar cells into duct-like cells in vitro
32. Analysis of K-ras gene mutations in rare pancreatic and ampullary tumours
33. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
34. Transforming growth factor alpha and epidermal growth factor in human pancreatic cancer
35. Recent discoveries in cancer genetics of exocrine pancreatic neoplasia
36. Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer
37. Microsatellite instability and the status of transforming growth factor-β type II gene in pancreatic adenocarcinoma
38. The K-ras mutation pattern in pancreatic ductal adenocarcinoma usually is identical to that in associated normal, hyperplastic, and metaplastic ductal epithelium
39. p53 and K-ras alterations in pancreatic epithelial lesions
40. DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1
41. Smad4/DPC4 silencing and hyperactive Ras jointly disrupt transforming growth factor-beta antiproliferative responses in colon cancer cells
42. Loss of expression of DPC4 in pancreatic intraepithelial neoplasia: Evidence that DPC4 inactivation occurs late in neoplastic progression
43. Overexpression of cyclin D1 in human pancreatic carcinoma is associated with poor prognosis
44. Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma
45. Pancreatitis and the risk of pancreatic cancer. International Pancreatitis Study Group
46. The risk of pancreatic cancer following pancreatitis: An association due to confounding?
47. p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis
48. Genetic alterations in chronic pancreatitis: Evidence for early occurrence of p53 but not K-ras mutations
49. Detection of mutations of p53 tumor suppressor gene in pancreatic juice and its application to diagnosis of patients with pancreatic cancer: Comparison with K-ras mutations
50. Diagnostic p53 immunostaining of endobiliary brush cytology: Preoperative cytology compared with the surgical specimen
51. Clinical significance of serum p53 antigen in patients with pancreatic carcinomas
52. Antibodies angainst p53 protein in serum of patients with benign or malignant pancreatic and biliary diseases
53. Analysis of K-ras gene mutation in hyperplastic duct cells of the pancreas without pancreatic disease
54. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia
55. Detection of pancreatic carcinoma: Diagnostic value of K-ras mutations in circulating DNA from serum
56. K-ras mutations in tissue and stool samples from patients with pancreatic cancer and chronic pancreatitis
57. Frequent loss of p16 expression and its correlation with clinico-pathological parameters in pancreatic carcinoma
58. Differential diagnosis of chronic pancreatitis and pancreatic cancer in brush cytology specimens
59. Overexpression of p53 protein during pancreatitis
60. Long-term follow-up of patients with chronic pancreatitis and K-ras gene mutation detected in pancreatic juice
61. Analysis of Ki-ras codon 12 mutations in the duodenal juice of patients with pancreatic cancer