The influence of surfactant HLB and oil/surfactant ratio on the formation and properties of self-emulsifying pellets and microemulsion reconstitution

AAPS PharmSciTech

Volumn 13, Issue 4, 2012, Pages 1319-1330

  Matsaridou, Irini ^a   Barmpalexis, Panagiotis ^a   Salis, Andrea ^a   Nikolakakis, Ioannis ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

disintegration and mechanical properties; FT IR and H bonding; microemulsion reconstitution; self emulsifying pellets; surfactant HLB and oil surfactant ratio

Indexed keywords

CREMOPHOR; HYDROGEN; SOLUTOL HS 15; TRIACYLGLYCEROL;

ARTICLE; DRUG PELLET; HYDROGEN BOND; HYDROPHILIC LIPOPHILIC BALANCE; INFRARED SPECTROSCOPY; LIGHT SCATTERING; MICROEMULSION; OIL SURFACTANT RATIO; PARTICLE SIZE; PELLET EXTRUSION; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SPHERONIZATION;

CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DRUG IMPLANTS; EMULSIONS; FATTY ACIDS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; OILS; PARTICLE SIZE; POLYETHYLENE GLYCOLS; SOLUBILITY; SURFACE-ACTIVE AGENTS; TRIGLYCERIDES; WATER;

EID: 84871666239     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-012-9855-7     Document Type: Article

References (25)

1. Newton M, Petterson J, Podczeck F, Clarke A, Booth S. The influence of formulation variables on the properties of pellets containing a self-emulsifying mixture. J Pharm Sci. 2001;90:987-95.
2. Tuleu C, Newton M, Rose J, Euler D, Saklatvala R, Clarke A, Booth S. Comparative bioavailablity study in dogs of a self-emulsifying formulation of progesterone presented in a pellet and liquid form compared with an aqueous suspension of progesterone. J Pharm Sci. 2004;93:1495-502.
3. Newton JM, Godinho A, Clarke AP, Booth SW. Formulation variables on pellets containing self-emulsifying systems. Pharm Technol Europe. 2005;17:29-32.
4. Abdalla A, Mader K. Preparation and characterization of a self- emulsifying pellet formulation. Eur J Pharm Biopharm. 2007;66:220-6.
5. Podczeck F, Alessi P, Newton JM. The preparation of pellets containing non-ionic surfactants by extrusion/spheronization. Int J Pharm. 2008;361:33-40.
6. Podczeck F, Maghetti A, Newton JM. The influence of non-ionic surfactants on the rheological properties of drug/microcrystalline cellulose/water mixtures and their use in the preparation and drug release performance of pellets prepared by extrusion/spheronization. Eur J Pharm Sci. 2009;37:334-40.
7. Bachynsky MO, Shah NH, Patel CI, Malick AW. Factors affecting the efficiency of a self-emulsifying oral delivery system. Drug Dev Ind Pharm. 1997;23:809-16.
8. Pouton CW. Self-emulsifying drug delivery systems: assessment of the efficiency of emulsification. Int J Pharm. 1985;17:335-48.
9. Abdalla A, Klein S, Mader K. A new self-emulsifying drug delivery system (SEDDS) for poorly soluble drugs: characterization, dissolution, in vitro digestion and incorporation into solid pellets. Eur J Pharm Sci. 2008;35:457-64.
10. Florence AT, Attwood, D. Physicochemical principles of pharmacy. 2nd ed. The Macmillan Press, New York; 1988. p. 239-40.
11. Ditner C, Bravo R, Imanidis G, Kuentz MA. Systematic dilution study of self-microemulsifying drug delivery systems in artificial intestinal fluid using dynamic laser light scattering. Drug Dev Ind Pharm. 2009;35:199-208.
12. Podczeck F, Newton JM. A shape factor to characterize the quality of spheroids. J Pharm Pharmacol. 1994;46:82-5.
13. Balaxi M, Nikolakakis I, Kachrimanis K, Malamataris S. Combined effects of wetting, drying, and microcrystalline cellulose type on the mechanical strength and disintegration of pellets. J Pharm Sci. 2009;98:676-89.
14. Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev. 1997;25:47-58.
15. Jeong SH, Park JH, Park K. In: Wassan KM, editor. Role of lipid-excipients in modifying oral and parenteral drug delivery. New Jersey: Wiley; 2007. p. 32-5.
16. Vervaet C, Baert L, Remon JP. Enhancement of in vitro drug release by using polyethylene glycol 400 and PEG-40 hydrogenated castor oil in pellets made by extrusion/spheronization. Int J Pharm. 1994;108:207-12.
17. Swenson ES, Milisen WB, Curatolo W. Intestinal permeability enhancement efficiency: acute local toxicity and reversibility. Pharm Res. 1994;11:1132-42.
18. Constantinides PP. Lipid microemulsions for improving drug dissolution and oral absorption: physical and biopharmaceutical aspects. Pharm Res. 1995;12:1561-72.
19. Pouton CW, Porter JHC. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv Drug Deliv Rev. 2008;60:625-37.
20. Shaw DJ. Introduction to colloid and surface chemistry. 3rd ed. London: Butterwoths; 1980. p. 85-6.
21. Strickley RG. Solubilizing excipients in oral and injectible formulations. Pharm Res. 2004;21:201-30.
22. Marechal Y, Chanzy H. The hydrogen bond network in Iβ cellulose as observed by infrared spectrometry. J Mol Struct. 2000;523:183-96.
23. Watanabe A, Morita S, Kokot S, Matsubara M, Fukai K, Ozaki Y. Drying process of microcrystalline cellulose studied by attenuated total reflection IR spectroscopy with two-dimensional correlation spectroscopy and principal component analysis. J Mol Struct. 2006;799:102-10.
24. Gardner KH, Blackwell J. The hydrogen bonding in native cellulose. Biochim Biophys Acta. 1974;343:232-7.
25. Nazzal S, Smalyukh II, Lavrentovich OD, Khan MA. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int J Pharm. 2002;235:247-65.