Combined effects of wetting, drying, and microcrystalline cellulose type on the mechanical strength and disintegration of pellets

Journal of Pharmaceutical Sciences

Volumn 98, Issue 2, 2009, Pages 676-689

  Balaxi, Maria ^a   Nikolakakis, Ioannis ^a   Kachrimanis, Kyriakos ^a   Malamataris, Stavros ^a  

^a ARISTOTLE UNIVERSITY OF THESSALONIKI   (Greece)

Author keywords

Extrusion spheronization; Freeze drying; Hornification; Microcrystalline cellulose; Pellets; Porosity; Wetting

Indexed keywords

2 PROPANOL; MICROCRYSTALLINE CELLULOSE; WATER; CELLULOSE; SODIUM CHLORIDE; WETTING AGENT;

ARTICLE; DRUG PELLET; FLUIDIZED BED; FREEZE DRYING; MICROWAVE RADIATION; POROSITY; SPHERONIZATION; TABLET DISINTEGRATION; TENSILE STRENGTH; WATER RETENTION; CHEMICAL MODEL; CHEMISTRY; COMPARATIVE STUDY; DRUG DOSAGE FORM; MECHANICAL STRESS; METHODOLOGY; PARTICLE SIZE; PHARMACEUTICS; SOLUBILITY; TIME; VOLATILIZATION;

2-PROPANOL; CELLULOSE; CHEMISTRY, PHARMACEUTICAL; DOSAGE FORMS; FREEZE DRYING; MICROWAVES; MODELS, CHEMICAL; PARTICLE SIZE; POROSITY; SODIUM CHLORIDE; SOLUBILITY; STRESS, MECHANICAL; TECHNOLOGY, PHARMACEUTICAL; TENSILE STRENGTH; TIME FACTORS; VOLATILIZATION; WATER; WETTING AGENTS;

EID: 59849094481     PISSN: 00223549     EISSN: 15206017     Source Type: Journal    
DOI: 10.1002/jps.21454     Document Type: Article

References (24)

1. Buckton G, Yonemochi E, Yoon WL, Moffat AC. 1999. Water sorption and near IR spectroscopy to study the differences between microcrystalline cellulose and silicified microcrystalline cellulose before and after wet granulation. Int J Pharm 181:41-47.
2. Edge S, Steele DF, Chen A, Tobyn MJ, Staniforth JN. 2000. The mechanical properties of compacts of microcrystalline cellulose and silicified microcrystalline cellulose. Int J Pharm 200:67-72.
3. Millili GP, Schwartz JB. 1990. The strength of microcrystalline cellulose pellets: The effect of granulating with water/ethanol mixtures. Drug Dev Ind Pharm 16:1411-1426.
4. Schröder M, Kleinebudde P. 1995. Structure of disintegrating pellets with regard to fractal geometry. Pharm Res 12:1694-1700.
5. Berggren J, Alderborn G. 2001. Drying behaviour of two sets of microcrystalline cellulose pellets. Int J Pharm 219:113-126.
6. Dreu R, Sirca J, Pintye-Hodi K, Burjan T, Planinsek O, Srcic S. 2005. Physicochemical properties of granulating liquids and their influence on microcrystalline cellulose pellets obtained by extrusionspheronization technology. Int J Pharm 291:99-111.
7. Bataille B, Ligarski K, Jacob M, Thomas C, Duru C. 1993. Study of the influence of spheronization and drying conditions on the physico-mechanical properties of neutral spheroids containing Avicel PH 101 and lactose. Drug Dev Ind Pharm 19:653-671.
8. Kleinebudde P. 1994. Shrinking and swelling properties of pellets containing microcrystalline cellulose and low substituted hydroxypropylcellulose: I. Shrinking properties. Int J Pharm 109:209-219.
9. Bashaiwoldu AB, Podczeck F, Newton JM. 2004. A study on the effect of drying techniques on the mechanical properties of pellets and compacted pellets. Eur J Pharm Sci 21:119-129.
10. Cosijns A, Nikolakakis I, Vervaet C, De Beer T, Siepmann F, Siepmann J, Remon J. 2006. Porous pellets as drug carriers. AAPS J 8: (S2) Abstract T2244.
11. Weise U. 1998. Hornification - Mechanisms and terminology. Paperi ja Puu/Paper Timber 80:110-115.
12. Kapsidou T, Nikolakakis I, Malamataris S. 2001. Agglomeration state and migration of drugs in wet granulations during drying. Int J Pharm 227:97-112.
13. Tomer G, Newton JM. 1999. A centrifuge technique for the evaluation of the extent of water movement in wet powder masses. Int J Pharm 188:31-38.
14. Nikolakakis I, Tsarvouli K, Malamataris S. 2006. Water retention and drainage in different brands of microcrystalline cellulose: Effect of measuring conditions. Eur J Pharm Biopharm 63:278-287.
15. Shipway PH, Hutchings IM. 1993. Attrition of brittle spheres by fracture under compression and impact loading. Powder Technol 76:23-30.
16. Luukkonen P. 2001. Rheological properties and the state of water of microcrystalline cellulose and silicified microcrystalline cellulose wet masses. Ph.D. Thesis, University of Helsinki, pp. 11, 40.
17. Matsuda Y, Isogai A, Onabe F. 1994. Effects of thermal and hydrothermal treatments on the reswelling capabilities of pulps and paper sheets. J Pulp Paper Sci 20:J323-J327.
18. Lustig-Gustafsson C, Kaur Johal H, Podczeck F, Newton JM. 1999. The influence of water content and drug solubility on the formulation of pellets by extrusion and spheronisation. Eur J Pharm Sci 8:147-152.
19. Khossravi D, Connors KA. 1993. Solvent effects on chemical processes. 3. Surface tension of binary aqueous organic solvents. J Sol Chem 22:321-330.
20. Ni H, Datta AK, Torrance KE. 1999. Moisture transport in intensive microwave heating of biomaterials: A multiphase porous media model. Int J Heat Mass Transfer 42:1501-1512.
21. Hlinak AJ, Clark BA. 2002. Drying and Dryers. In: Swarbrick J, Boylan JC, editors. Encyclopedia of pharmaceutical technology, Vol. 1. New York: Marcel Dekker. pp 1030-1031.
22. McLoughlin CM, McMinn WAM, Magee TRA. 2000. Microwave drying of pharmaceutical powders. Trans ICheme 78: Part C90-C96.
23. Pikal MJ. 2002. Freeze drying. In: Swarbrick J, Boylan JC, editors. Encyclopedia of pharmaceutical technology, Vol. 2. New York: Marcel Dekker. pp 1299-132623.
24. Kachrimanis K, Nikolakakis I, Malamataris S. 2003. Tensile strength and disintegration of tableted silicified microcrystalline cellulose: Influences of interparticle bonding. J Pharm Sci 92:1489-1501.