Interleukin-27: A potential new sepsis biomarker exposed through genome-wide transcriptional profiling

Critical Care

Volumn 16, Issue 6, 2012, Pages

  Scicluna, Brendon P ^a   van der Poll, Tom ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CYTOKINE; INTERLEUKIN 27; INTERLEUKIN 27P28; UNCLASSIFIED DRUG; INTERLEUKIN DERIVATIVE;

BACTERIAL INFECTION; CRITICALLY ILL PATIENT; GENE EXPRESSION; GENOME; HOSPITAL ADMISSION; HUMAN; IMMUNE RESPONSE; INFLAMMATION; INTENSIVE CARE UNIT; LEUKOCYTE; MEDICAL DECISION MAKING; NONHUMAN; NOTE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RNA SEQUENCE; SEPSIS; BLOOD; FEMALE; MALE;

FEMALE; HUMANS; INTERLEUKINS; MALE; SEPSIS;

EID: 84871659467     PISSN: 13648535     EISSN: 1466609X     Source Type: Journal    
DOI: 10.1186/cc11893     Document Type: Note

References (7)

1. Wong HR, Cvijanovich NZ, Hall M, Allen GL, Thomas NJ, Freishtat RJ, Anas N, Meyer K, Checchia PA, Lin R, Bigham MT, Sen A, Nowak J, Quasney M, Henricksen JW, Chopra A, Banschbach S, Beckman E, Harmon K, Lahni P, Shanley TP. Interleukin-27 is a novel candidate diagnostic biomarker for bacterial infection in critically ill children. Crit Care 2012, 16:R213. 10.1186/cc11847, 23107287.
2. Wirtz S, Tubbe I, Galle PR, Schild HJ, Birkenbach M, Blumberg RS, Neurath MF. Protection from lethal septic peritonitis by neutralizing the biological function of interleukin 27. J Exp Med 2006, 203:1875-1881. 10.1084/jem.20060471, 2118378, 16880260.
3. Rinchai D, Khaenam P, Kewcharoenwong C, Buddhisa S, Pankla R, Chaussabel D, Bancroft GJ, Lertmemongkolchai G. Production of interleukin-27 by human neutrophils regulates their function during bacterial infection. Eur J Immunol 2012,
4. Tang BM, Huang SJ, McLean AS. Genome-wide transcription profiling of human sepsis: a systematic review. Crit Care 2010, 14:R237. 10.1186/cc9392, 3219990, 21190579.
5. Wong HR. Clinical review: sepsis and septic shock--the potential of gene arrays. Crit Care 2012, 16:204.
6. Wang H, Zhang P, Chen W, Feng D, Jia Y, Xie L. Serum microRNA signatures identified by Solexa sequencing predict sepsis patients' mortality: a prospective observational study. PLoS One 2012, 7:e38885. 10.1371/journal.pone.0038885, 3376145, 22719975.
7. Sutherland A, Thomas M, Brandon RA, Brandon RB, Lipman J, Tang B, McLean A, Pascoe R, Price G, Nguyen T, Stone G, Venter D. Development and validation of a novel molecular biomarker diagnostic test for the early detection of sepsis. Crit Care 2011, 15:R149. 10.1186/cc10274, 3219023, 21682927.