Effect of endogenous steroid hormones on 17-alpha-hydroxyprogesterone caproate metabolism

American Journal of Obstetrics and Gynecology

Volumn 208, Issue 1, 2013, Pages 86.e1-86.e6

  Cuppett, Courtney D ^a   Zhao, Yang ^b   Caritis, Steve ^a   Zhang, Shimin ^b   Zhao, Wenchen ^b   Venkataramanan, Raman ^b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

17 alpha hydroxyprogesterone caproate; drug drug interaction; human liver microsome; metabolism; steroid hormone

Indexed keywords

ESTRADIOL; ESTRIOL; ESTRONE; HYDROXYPROGESTERONE; HYDROXYPROGESTERONE CAPROATE; PROGESTERONE; STEROID HORMONE;

ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG METABOLISM; ESTRADIOL BLOOD LEVEL; ESTRIOL BLOOD LEVEL; ESTRONE BLOOD LEVEL; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONE BLOOD LEVEL; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; INCUBATION TEMPERATURE; LIVER MICROSOME; PRIORITY JOURNAL; PROGESTERONE BLOOD LEVEL; STEROID METABOLISM; ULTRAVIOLET RADIATION;

EID: 84871614421     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2012.09.021     Document Type: Article

References (21)

1. P.J. Meis, M. Klebanoff, E. Thom Prevention of recurrent preterm delivery by 17 alpha-hydroxyprogesterone caproate New Engl J Med 348 2003 2379 2385
2. S.N. Caritis, S. Sharma, and R. Venkataramanan Pharmacokinetics of 17-hydroxyprogesterone caproate in multifetal gestation Am J Obstet Gynecol 205 2011 40.e1 40.e8
3. S. Sharma, J. Ou, S. Strom, D. Mattison, S. Caritis, R. Venkataramanan Identification of enzymes involved in the metabolism of 17alpha hydroxyprogesterone caproate: an effective agent for prevention of preterm birth Drug Metab Dispos 9 2008 1896 1902
4. H. Yamazaki, P.M. Shaw, F.P. Guengerich, T. Shimada Roles of cytochromes P450 1A2 and 3A4 in the oxidation of estradiol and estrone in human liver microsomes Chem Res Toxicol 11 1998 659 665
5. M.A. Sarkar, V. Vadlamuri, S. Ghosh, D.D. Glover Expression and cyclic variability of CYP3A4 and CYP3A7 isoforms in human endometrium and cervix during the menstrual cycle Drug Metab Dispos 31 2003 1 6
6. F.P. Guengerich Oxidation of 17 alpha-ethynylestradiol by human liver cytochrome P-450 Mol Pharmacol 33 1988 500 508
7. V. Kerlan, Y. Dreano, J.P. Bercovici, P.H. Beaune, H.H. Floch, F. Berthou Nature of cytochromes P450 involved in the 2-/4-hydroxylations of estradiol in human liver microsomes Biochem Pharmacol 44 1992 1745 1756
8. H. Yamazaki, T. Shimada Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes Arch Biochem Biophys 346 1997 161 169
9. A.F. Badawi, E.L. Cavalieri, E.G. Rogan Role of human cytochrome P450 1A1, 1A2, 1B1, and 3A4 in the 2-, 4-, and 16alpha-hydroxylation of 17beta-estradiol Metabolism 50 2001 1001 1003
10. H. Nakamura, H. Nakasa, I. Ishii Effects of endogenous steroids on CYP3A4-mediated drug metabolism by human liver microsomes Drug Metab Dispos 30 2002 534 540
11. C.D. Sohl, Q. Cheng, F.P. Guengerich Chromatographic assays of drug oxidation by human cytochrome P450 3A4 Nat Protoc 4 2009 1252 1257
12. P. O'Leary, P. Boyne, P. Flett, J. Beilby, I. James Longitudinal assessment of changes in reproductive hormones during normal pregnancy Clin Chem 37 1991 667 672
13. D. Tulchinsky, C.J. Hobel Plasma human chorionic gonadotropin, estrone, estradiol, estriol, progesterone, and 17 alpha-hydroxyprogesterone in human pregnancy; 3, early normal pregnancy Am J Obstet Gynecol 117 1973 884 893
14. B.S. Block, G.C. Liggins, R.K. Creasy Preterm delivery is not predicted by serial plasma estradiol or progesterone concentration measurements Am J Obstet Gynecol 150 1984 716 722
15. S. Batra, N.O. Sjoberg, A. Aberg Human placental lactogen, estradiol-17beta, and progesterone levels in the third trimester and their respective values for detecting twin pregnancy Am J Obstet Gynecol 131 1978 69 72
16. U. Goktolga, S. Gungor, S.T. Ceyhan Assessment of the predictive value of serum progesterone levels on early pregnancy prognosis in spontaneous twin gestations: a prospective study Eur J Obstet Gynecol Reprod Biol 137 2008 185 188
17. R. Smith, J.I. Smith, X. Shen Patterns of plasma corticotropin-releasing hormone, progesterone, estradiol, and estriol change and the onset of human labor J Clin Endocrinol Metab 94 2009 2066 2074
18. D.D. Glover, M. Amonkar, B.F. Rybeck, T.S. Tracy Prescription, over-the-counter, and herbal medicine use in a rural, obstetric population Am J Obstet Gynecol 188 2003 1039 1045
19. J.D. Rubin, C. Ferencz, C. Loffredo Use of prescription and non-prescription drugs in pregnancy; the Baltimore-Washington Infant Study Group J Clin Epidemiol 46 1993 581 589
20. W.S. Webster, J.A. Freeman Prescription drugs and pregnancy Expert Opin Pharmacother 4 2003 949 961
21. J. Horn, P. Hansten Get to know an enzyme: CYP3A4 Pharmacy Times 37 2008 http://pharmacytimes.com/publications/issue/2008/2008-09/2008-09-8687 Accessed March 29, 2012