Neuromuscular dysfunction in diabetes: Role of nerve impairment and training status

Medicine and Science in Sports and Exercise

Volumn 45, Issue 1, 2013, Pages 52-59

  Sacchetti, Massimo Scotto ^a   Balducci, Stefano ^b,c   Bazzucchi, Ilenia ^a   Carlucci, Flaminia ^a   Di Palumbo, Alessandro Scotto ^a   Haxhi, Jonida ^a   Conti, Francesco ^b   Di Biase, Nicolina ^d   Calandriello, Eugenio ^e   Pugliese, Giuseppe ^b  

^a UNIVERSITY OF ROME FORO ITALICO   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c Metabolic Fitness Association   (Italy)

^d FATEBENEFRATELLI HOSPITAL   (Italy)

^e REGINA APOSTOLORUM HOSPITAL   (Italy)

Author keywords

diabetic polyneuropathy; muscle fiber conduction velocity; Muscle strength; torque velocity relationship

Indexed keywords

AGED; ARTICLE; BIOMECHANICS; CASE CONTROL STUDY; CLINICAL TRIAL; DIABETIC NEUROPATHY; ELECTROMYOGRAPHY; HUMAN; INNERVATION; INSULIN DEPENDENT DIABETES MELLITUS; KINESIOTHERAPY; MALE; MIDDLE AGED; MOTONEURON; MUSCLE CONTRACTION; MUSCLE STRENGTH; NERVE CONDUCTION; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PHYSIOLOGY; SINGLE BLIND PROCEDURE; SKELETAL MUSCLE; TORQUE;

AGED; BIOMECHANICS; CASE-CONTROL STUDIES; DIABETES MELLITUS, TYPE 1; DIABETES MELLITUS, TYPE 2; DIABETIC NEUROPATHIES; ELECTROMYOGRAPHY; EXERCISE THERAPY; HUMANS; MALE; MIDDLE AGED; MOTOR NEURONS; MUSCLE CONTRACTION; MUSCLE STRENGTH; MUSCLE, SKELETAL; NEURAL CONDUCTION; SINGLE-BLIND METHOD; TORQUE;

EID: 84871608810     PISSN: 01959131     EISSN: 15300315     Source Type: Journal    
DOI: 10.1249/MSS.0b013e318269f9bb     Document Type: Article

References (40)

1. Andersen H, Nielsen S, Mogensen CE, Jakobsen J. Muscle strength in type 2 diabetes. Diabetes. 2004;53:1543-8. (Pubitemid 38697667)
2. Andersen H, Poulsen PL, Mogensen CE, Jakobsen J. Isokinetic muscle strength in long-term IDDM patients in relation to diabetic complications. Diabetes. 1996;45:440-5. (Pubitemid 26110249)
3. Andersen H, Stalberg E, Gjerstad MD, Jakobsen J. Association of muscle strength and electrophysiological measures of reinnervation in diabetic neuropathy. Muscle Nerve. 1998;21: 1647-54. (Pubitemid 28545693)
4. Andreassen CS, Jakobsen J, Andersen H. Muscle weakness: a progressive late complication in diabetic distal symmetric polyneuropathy. Diabetes. 2006;55:806-12. (Pubitemid 43343240)
5. Andreassen CS, Jakobsen J, Ringgaard S, Ejskjaer N, Andersen H. Accelerated atrophy of lower leg and foot muscles-a follow-up study of long-term diabetic polyneuropathy using magnetic resonance imaging (MRI). Diabetologia. 2009;52:1182-91.
6. Balducci S, Iacobellis G, Parisi L, et al. Exercise training can modify the natural history of diabetic peripheral neuropathy. J Diabetes Complications. 2006;20:216-23. (Pubitemid 43949348)
7. Balducci S, Zanuso S, Nicolucci A, et al. Effect of an intensive exercise intervention strategy on modifiable cardiovascular risk factors in subjects with type 2 diabetes mellitus: a randomized controlled trial: the Italian Diabetes and Exercise Study (IDES). Arch Intern Med. 170(20):1794-803.
8. Bassey EJ, Fiatarone MA, O'Neill EF, Kelly M, Evans WJ, Lipsitz LA. Leg extensor power and functional performance in very old men and women. Clin Sci (Lond). 1992;82:321-7.
9. Bazzucchi I, Felici F, Macaluso A, De Vito G. Differences between young and older women in maximal force, force fluctuations, and surface EMG during isometric knee extension and elbow flexion. Muscle Nerve. 2004;30:626-35. (Pubitemid 39447287)
10. Caiozzo VJ. Plasticity of skeletal muscle phenotype: mechanical consequences. Muscle Nerve. 2002;26:740-68. (Pubitemid 35424425)
11. Cameron NE, Cotter MA, Robertson S. Changes in skeletal muscle contractile properties in streptozocin-induced diabetic rats and role of polyol pathway and hypoinsulinemia. Diabetes. 1990;39:460-5. (Pubitemid 20111429)
12. Canepari M, Pellegrino MA, D'Antona G, Bottinelli R. Skeletal muscle fibre diversity and the underlying mechanisms. Acta Physiol (Oxf). 2010;199:465-76.
13. Cetinus E, Buyukbese MA, Uzel M, Ekerbicer H, Karaoguz A. Hand grip strength in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2005;70:278-86. (Pubitemid 41539790)
14. Chisari C, Piaggesi A, Baccetti F, Licitra R, Rossi B. Muscle modification in asymptomatic diabetic neuropathy: a surface electromyographic study. Basic Appl Myol. 2002;12:177-81.
15. Clark DJ, Patten C, Reid KF, Carabello RJ, Phillips EM, Fielding RA. Impaired voluntary neuromuscular activation limits muscle power in mobility-limited older adults. J Gerontol A Biol Sci Med Sci. 2010;65:495-502.
16. Colberg SR, Sigal RJ, Fernhall B, et al. Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement executive summary. Diabetes Care. 2010;33:2692-6.
17. Cotter M, Cameron NE, Lean DR, Robertson S. Effects of longterm streptozotocin diabetes on the contractile and histochemical properties of rat muscles. Q J Exp Physiol. 1989;74:65-74. (Pubitemid 19041682)
18. Gaster M, Staehr P, Beck-Nielsen H, Schroder HD, Handberg A. GLUT4 is reduced in slow muscle fibers of type 2 diabetic patients: is insulin resistance in type 2 diabetes a slow, type 1 fiber disease? Diabetes. 2001;50:1324-9. (Pubitemid 32500164)
19. Gregg EW, Beckles GL, Williamson DF, et al. Diabetes and physical disability among older U. S. adults. Diabetes Care. 2000;23:1272-7.
20. Grossie J. Contractile and electrical characteristics of extensor muscle from alloxan-diabetic rats. An in vitro study. Diabetes. 1982;31:194-202. (Pubitemid 12170289)
21. Ijzerman TH, Schaper NC, Melai T, et al. Motor nerve decline does not underlie muscle weakness in type 2 diabetic neuropathy. Muscle Nerve. 2011;44:241-5.
22. Ijzerman TH, Schaper NC, Melai T, Meijer K, Willems PJ, Savelberg HH. Lower extremity muscle strength is reduced in people with type 2 diabetes, with and without polyneuropathy, and is associated with impaired mobility and reduced quality of life. Diabetes Res Clin Pract. 2012;95:345-51.
23. Jurkat-Rott K, Holzherr B, Fauler M, Lehmann-Horn F. Sodium channelopathies of skeletal muscle result from gain or loss of function. Pflugers Arch. 460:239-48.
24. Lesniewski LA, Miller TA, Armstrong RB. Mechanisms of force loss in diabetic mouse skeletal muscle. Muscle Nerve. 2003;28: 493-500. (Pubitemid 37193778)
25. Lin-Shiau SY, Liu SH, Lin MJ. Use of ion channel blockers in the exploration of possible mechanisms involved in the myopathy of diabetic mice. Naunyn Schmiedebergs Arch Pharmacol. 1993;348: 311-8.
26. Meijer JW, Lange F, Links TP, van der Hoeven JH. Muscle fiber conduction abnormalities in early diabetic polyneuropathy. Clin Neurophysiol. 2008;119:1379-84.
27. Merletti R, Farina D, Gazzoni M. The linear electrode array: a useful tool with many applications. J Electromyogr Kinesiol. 2003;13:37-47. (Pubitemid 35463191)
28. Oberbach A, Bossenz Y, Lehmann S, et al. Altered fiber distribution and fiber-specific glycolytic and oxidative enzyme activity in skeletal muscle of patients with type 2 diabetes. Diabetes Care. 2006;29:895-900. (Pubitemid 44115313)
29. Park SW, Goodpaster BH, Strotmeyer ES, et al. Decreased muscle strength and quality in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes. 2006;55:1813-8. (Pubitemid 44324137)
30. Park SW, Goodpaster BH, Strotmeyer ES, et al. Accelerated loss of skeletal muscle strength in older adults with type 2 diabetes: the health, aging, and body composition study. Diabetes Care. 2007;30:1507-12. (Pubitemid 46871162)
31. Paulus SF, Grossie J. Skeletal muscle in alloxan diabetes. A comparison of isometric contractions in fast and slow muscle. Diabetes. 1983;32:1035-9. (Pubitemid 14225121)
32. Raj IS, Bird SR, Shield AJ. Aging and the force-velocity relationship of muscles. Exp Gerontol. 45:81-90.
33. Sanchez OA, Snow LM, Lowe DA, Serfass RC, Thompson LV. Effects of endurance exercise-training on single-fiber contractile properties of insulin-treated streptozotocin-induced diabetic rats. J Appl Physiol. 2005;99:472-8. (Pubitemid 41061138)
34. Sayer AA, Dennison EM, Syddall HE, Gilbody HJ, Phillips DI, Cooper C. Type 2 diabetes, muscle strength, and impaired physical function: the tip of the iceberg? Diabetes Care. 2005;28:2541-2. (Pubitemid 41384309)
35. Stenholm S, Harkanen T, Sainio P, Heliovaara M, Koskinen S. Long-term changes in handgrip strength in men and women-accounting the effect of right censoring due to death. J Gerontol A Biol Sci Med Sci. 2012;67(10):1068-74.
36. Stephenson GM, O'Callaghan A, Stephenson DG. Single-fiber study of contractile and biochemical properties of skeletal muscles in streptozotocin-induced diabetic rats. Diabetes. 1994;43:622-8. (Pubitemid 24138772)
37. Tax AA, Denier van der Gon JJ, Gielen CC, van den Tempel CM. Differences in the activation of m. biceps brachii in the control of slow isotonic movements and isometric contractions. Exp Brain Res. 1989;76:55-63. (Pubitemid 19167218)
38. van Bolhuis BM, Medendorp WP, Gielen CC. Motor unit firing behavior in human arm flexor muscles during sinusoidal isometric contractions and movements. Exp Brain Res. 1997;117:120-30. (Pubitemid 27448037)
39. Zanuso S, Jimenez A, Pugliese G, Corigliano G, Balducci S. Exercise for the management of type 2 diabetes: a review of the evidence. Acta Diabetol. 2009;47:15-22.
40. Zwarts MJ, Stegeman DF. Multichannel surface EMG: basic aspects and clinical utility. Muscle Nerve. 2003;28:1-17. (Pubitemid 36775954)