Do clinical guidelines improve management of sepsis in critically ill elderly patients? A before-and-after study of the implementation of a sepsis protocol

Wiener Klinische Wochenschrift

Volumn 124, Issue 19-20, 2012, Pages 692-698

  Heppner, Hans Jürgen ^a,b   Singler, Katrin ^a,b   Kwetkat, Anja ^c   Popp, Steffen ^a   Esslinger, Adelheid Susanne ^d   Bahrmann, Philipp ^a,b   Kaiser, Matthias ^a,b   Bertsch, Thomas ^a   Sieber, Cornel Christian ^a,b   Christ, Michael ^a  

^a KLINIKUM NÜRNBERG   (Germany)

^b UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

^d AALEN UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; LACTIC ACID;

AGED; ANTIBIOTIC THERAPY; ARTICLE; BLOOD CULTURE; CENTRAL VENOUS CATHETER; CENTRAL VENOUS PRESSURE; CRITICALLY ILL PATIENT; ELDERLY CARE; FEMALE; FLUID RESUSCITATION; GROUPS BY AGE; HUMAN; INTENSIVE CARE UNIT; MAJOR CLINICAL STUDY; MALE; MORTALITY; PRACTICE GUIDELINE; SEPSIS; SEX DIFFERENCE; TREATMENT OUTCOME; VENOUS OXYGEN TENSION;

AGED; CRITICAL CARE; CRITICAL ILLNESS; FEMALE; GERMANY; GUIDELINE ADHERENCE; HUMANS; MALE; PRACTICE GUIDELINES AS TOPIC; PREVALENCE; RISK FACTORS; SEPSIS; SURVIVAL ANALYSIS; SURVIVAL RATE; TREATMENT OUTCOME;

EID: 84871600900     PISSN: 00435325     EISSN: 16137671     Source Type: Journal    
DOI: 10.1007/s00508-012-0229-7     Document Type: Article

References (41)

1. El Solh AA, Akinnusi ME, Alsawalha LN, et al. Outcome of septic shock in older adults after implementation of the sepsis "bundle". J Am Geriatr Soc. 2008;56:272-8.
2. Angus DC, Linde-Zwirble WT, Lidicker J, et al. Epidemiology of severe sepsis in the United States: Analysis of incidence outcome and associated costs of care. Crit Care Med. 2001;29:1303-10.
3. Martin GS, Mannino DM, Eaton S, et al. The epidemiology of sepsis in the United States from 1979 through 2000. N Engl J Med. 2003;348:1546-54.
4. Kollef MH, Micek ST. Using protocols to improve patient outcomes in the intensive care unit: Focus on mechanical ventilation and sepsis. Semin Respir Crit Care Med. 2010;31:19-30.
5. Toussaint S, Gerlach H. Sepsis-klinischer Stellenwert der Sepsisbündel und Möglichkeiten der Implementierung. Anästheol Intensivmed Notfallmed Schmetrzther. 2010;45:566-71.
6. Karbach U, Schubert I, Hagemeister J, et al. Physicians' knowledge of and compliance with guidelines: An exploratory study in cardiovascular diseases. Dtsch Arzteblatt. 2011;108(5):61-9.
7. Rivers E, Nguyen B, Havstad S, et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med. 2001;345:1368-77.
8. Beal Al, Cerra FB. Multiple organ failure syndrome in the 1990s: Systemic inflammatory response and organ dysfunction. JAMA. 1994;271:226-33.
9. Barochia AV, Cui X, Vitberg D, et al. Bundled care for septic shock: An analysis of clinical trials. Crit Care Med. 2010;38:668-78.
10. Dellinger RP, Levy MM, Carlet JM, et al. Surviving Sepsis Campaign: International guidelines for management of severe sepsis and septic shock. Crit Care Med. 2008;36:296-327.
11. Brunkhorst FM, Gastmeier P, Kern W, et al. Prevention and follow-up care of sepsis. 1st revision of S2k guidelines of the German Sepsis Society. Internist. 2001;51:925-32.
12. Schmidt GA. Counterpoint: Adherence to early goaldirected therapy: Does it really matter? No. Both risks and benefits require further study.Chest. 2010;138:480-3.
13. Reade MC, Huang DT, Bell D, et al. Variability in management of early severe sepsis. Emerg J Med. 2010;27:110-5.
14. Jones AE, Kline JA. Use of goal-directed therapy for severe sepsis and septic shock in academic emergency departments. Crit Care Med. 2005;33:1888-9.
15. Levey MM, Dellinger RP, Townsend SR, et al. The surviving sepsis campaign: Results of an international guideline-based performance improvement program targeting severe sepsis. Intensive Care Med. 2010;36:222-31.
16. Esslinger AS, Meier F, Roller-Wirnsberger R, et al. Attitudes towards age-related rationing of medical supply: Results of a cross-national analysis in Germany and Austria. Wien Klin Wochenschr. 2011;123:422-31.
17. Donnino MW, Clardy P, Talmor D. A central venous pressure goal of 8-12 mmHg for all patients in septic shock. Crit Care Med. 2007;35:1441.
18. Prasad M, Christie JD, Bellamy SL, et al. The availability of clinical protocols in US teaching intensive care units. J Crit Care. 2010;4:610-9.
19. Wright SW, Trott A, et al. Creating a system to facilitate translation of evidence into standardized clinical practice: A preliminary report. Ann Emerg Med. 2008;51:80-6.
20. Trzeciak S, Dellinger RP, Abate NL, et al. Translating research to clinical practice. A 1-year experience with implementing early-goal-directed therapy for septic shock in the emergency department. Chest. 2006,129;225-32.
21. Gao F, Melody T, Daniels D, et al. The impact of compliance with 6-hour and 24-hour sepsis bundles on hospital mortality in patients with severe sepsis: A prospective observational study. Crit Care. 2005;9:R764-70.
22. Shapiro NI, Howell MD, Talmor D, et al. Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol. Crit Care Med. 2006;34:1025-32.
23. Kollef MH. Inadequate antimicrobial treatment: An important determinant of outcome for hospitalized patients. Clin Infect Dis. 2000;31:S131-8.
24. Ibrahim EH, Sherman G, Ward S, et al. The influence of inadequate antimicrobial treatment of bloodstream infections on patient outcomes in the ICU setting. Chest. 2000;118:146-55.
25. Kollef MH, Sherman G, Ward S, et al. Inadequate antimicrobial treatment of infections: A risk factor for hospital mortality among critically ill patients. Chest. 1999;115:462-74.
26. Capelastegui A, Espana PP, Quintana JM, et al. Improvement of process-of-care and outcomes after implementing a guideline fort he management of community-acquiredpneumonia: A controlled before-and-after design study. Clin Infect Dis. 2004; 39:955-63.
27. Ely EW, Baker AM, Dunagan DP, et al. Effect on the duration of mechanical ventilation of identifying patients capable of breathing spontaneously. N Engl J Med. 1996;335:1864-9.
28. Brook AD, Ahrens TS, Schaiff R, et al. Effect of a nursingimplemented sedation protocol on the duration of mechanical ventilation. Crit Care Med. 1999;27:2609-15.
29. Ibrahim EH, Ward S, Sherman G, et al. Experience with a clinical guideline for the treatment of ventilator-associated pneumonia. Crit Care Med. 2001;29:1109-15.
30. Martinez R, Reyes S, Lorenzo MJ, et al. Impact of guidelines on outcome: The evidence. Semin Respir Crit Care Med. 2009;30:172-8.
31. Ferrer R, Artigas A, Suarez D, et al. Effectiveness of treatments for severe sepsis: A prospective, multicenter, observational study. Am J Resp Crit Care. 2009;180:861-6.
32. Micek ST, Roubinian N, Heuring T, et al. Before-after study of a standardized hospital order set for the management of septic shock. Crit Care Med. 2006;34(11):2707-13.
33. Kortgen A, Niederprüm P, Bauer M. Implementation of an evidence-based "standard operating procedure" and outcome in septic shock. Crit Care Med. 2006;34:943-9.
34. Kumar A, Roberts D, Wood KE, et al. Duration of hypotension before initiation of effective antimicrobial therapy is the critical determinant of survival in human septic shock. Crit Care Med. 2006;34:1589-96.
35. Otero RM, Nguyen HB, Huang DT, et al. Early goal-directed therapy in severe sepsis and septic shock revisitted. Concepts, controversies, and contempary findings. Chest. 2006;130:1579-95.
36. Berwick DM. Disseminating innovations in health care. JAMA. 2003;289:1969-75.
37. Levey MM, Pronovost PJ, Dellinger RP, et al. Sepsis change bundles: Converting guidelines into meaningful change in behavior and clinical outcome. Crit Care Med. 2004;32:S595-7.
38. Phua J, Koh Y, Du B, et al. Management of severe sepsis in patients admitted to Asian intensive care units: Prospective cohort study. BMJ. 2011;342:d3245.
39. Foy R, Walker A, Ramsay C, et al. Theory-based identification of barriers to quality-improvement: Induced abortion care. Int J Qual Health Care. 2005;17:147-55.
40. Cabanna MD Rand CS, Powe NR, et al. Why don't physicians follow clinical practice guidelines.JAMA. 1999;282:1458-65.
41. Berenholtz S, et al. Barriers to translating evidence into practice. Curr Opin Crit Care. 2003;4:321-5.