The biology of Mycobacterium cord factor and roles in pathogen-host interaction

Critical Reviews in Eukaryotic Gene Expression

Volumn 22, Issue 4, 2012, Pages 289-297

  Li, Chunmei ^a   Du, Qinglin ^a   Deng, Wanyan ^a   Xie, Jianping ^a  

^a SOUTHWEST UNIVERSITY   (China)

Author keywords

Cord factor; Metabolic pathway; Mycobacterium; Receptors

Indexed keywords

COMPLEMENT COMPONENT C5A; CORD FACTOR; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 27; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; BIODEGRADATION; CYTOKINE PRODUCTION; DRUG EFFECT; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; HOST PATHOGEN INTERACTION; MYCOBACTERIUM; MYCOBACTERIUM SMEGMATIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL;

CORD FACTORS; HOST-PATHOGEN INTERACTIONS; HUMANS; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

MYCOBACTERIUM; MYCOBACTERIUM TUBERCULOSIS;

EID: 84871593775     PISSN: 10454403     EISSN: None     Source Type: Journal    
DOI: 10.1615/CritRevEukarGeneExpr.v22.i4.30     Document Type: Article

References (59)

1. Brennan PJ. Structure, function, and biogenesis of the cell wall of Mycobacterium tuberculosis. Tuberculosis (Edinb). 2003;83(1-3):91-97.
2. Smith I. Mycobacterium tuberculosis pathogenesis and molecular determinants of virulence. Clin Microbiol Rev. 2003 Jul;16(3):463-96.
3. Middlebrook G, Dubos RJ, Pierce C. Virulence and morphological characteristics of mammalian tubercle bacilli. J Exp Med. 1947 Jul 31;86(2):175-84.
4. Bloch H, Noll H. Studies on the virulence of tubercle bacilli; the effect of cord factor on murine tuberculosis. Br J Exp Pathol. 1955 Feb;36(1):8-17.
5. Bloch H, Sorkin E, Erlenmeyer H. A toxic lipid component of the tubercle bacillus (cord factor). I. Isolation from petroleum ether extracts of young bacterial cultures. Am Rev Tuberc. 1953 May;67(5):629-43.
6. Julian E, Roldan M, Sanchez-Chardi A, Astola O, Agusti G, Luquin M. Microscopic cords, a virulence-related characteristic of Mycobacterium tuberculosis, are also present in nonpathogenic mycobacteria. J Bacteriol. 2010 Apr;192(7):1751-60.
7. Glickman MS, Cox JS, Jacobs WR, Jr. A novel mycolic acid cyclopropane synthetase is required for cording, persistence, and virulence of Mycobacterium tuberculosis. Mol Cell. 2000 Apr;5(4):717-27.
8. Barkan D, Rao V, Sukenick GD, Glickman MS. Redundant function of cmaA2 and mmaA2 in Mycobacterium tuberculosis cis cyclopropanation of oxygenated mycolates. J Bacteriol. 2010 Jul;192(14):3661-68.
9. Noll H, Bloch H, Asselineau J, Lederer E. The chemical structure of the cord factor of Mycobacterium tuberculosis. Biochim Biophys Acta. 1956 May;20(2):299-309.
10. Mederos L, Valdivia JA, Valero-Guillen PL. Analysis of the structure of mycolic acids of Mycobacterium simiae reveals a particular composition of alpha-mycolates in strain 'habana' TMC 5135, considered as immunogenic in tuberculosis and leprosy. Microbiology. 2007 Dec;153(Pt 12):4159-65.
11. Mederos LM, Montoro EH, Bernabeu A, Linares C, Valero-Guillen PL. Structural studies of cord factors from Mycobacterium simiae related to the capacity for tumour necrosis factor alpha (α-TNF) induction. Microbiology. 2010;156(12):3744-53.
12. Rao V, Fujiwara N, Porcelli SA, Glickman MS. Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule. J Exp Med. 2005 Feb 21;201(4):535-43.
13. Retzinger GS MS, Takayama K, Hunter RL, Kezdy FJ. The role of surface in the biological activities of trehalose 6,6′-dimycolate. Surface properties and development of a model system. J Biol Chem. 1981;256:8208-16.
14. Indrigo J, Hunter RL, Jr., Actor JK. Cord factor trehalose 6,6′-dimycolate (TDM) mediates trafficking events during mycobacterial infection of murine macrophages. Microbiology. 2003 Aug;149(Pt 8):2049-59.
15. Glickman MS, Cahill SM, Jacobs WR, Jr. The Mycobacterium tuberculosis cmaA2 gene encodes a mycolic acid trans-cyclopropane synthetase. J Biol Chem. 2001 Jan 19;276(3):2228-33.
16. Fujita Y, Okamoto Y, Uenishi Y, Sunagawa M, Uchiyama T, Yano I. Molecular and supra-molecular structure related differences in toxicity and granulomatogenic activity of mycobacterial cord factor in mice. Microb Pathog. 2007 Jul;43(1):10-21.
17. Bowdish DM, Sakamoto K, Kim MJ, Kroos M, Mukho-padhyay S, Leifer CA, Tryggvason K, Gordon S, Russell DG. MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis. PLoS Pathog. 2009 Jun;5(6):e1000474.
18. Belisle JT, Vissa VD, Sievert T, Takayama K, Brennan PJ, Besra GS. Role of the major antigen of Mycobacterium tuberculosis in cell wall biogenesis. Science. 1997 May 30;276(5317):1420-22.
19. Takayama K, Wang C, Besra GS. Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis. Clin Microbiol Rev. 2005 Jan;18(1):81-101.
20. Silva CL, Ekizlerian SM, Fazioli RA. Role of cord factor in the modulation of infection caused by mycobacteria. Am J Pathol. 1985 Feb;118(2):238-47.
21. Kilburn JO, Takayama K, Armstrong EL. Synthesis of trehalose dimycolate (cord factor) by a cell-free system of Mycobacterium smegmatis. Biochem Biophys Res Commun. 1982 Sep 16;108(1):132-39.
22. Matsunaga I, Naka T, Talekar RS, McConnell MJ, Katoh K, Nakao H, Otsuka A, Behar SM, Yano I, Moody DB, Sugita M. Mycolyltransferase-mediated glycolipid exchange in Mycobacteria. J Biol Chem. 2008 Oct 24;283(43):28835-41.
23. Shimakata T, Minatogawa Y. Essential role of trehalose in the synthesis and subsequent metabolism of corynomycolic acid in Corynebacterium matruchotii. Arch Biochem Biophys. 2000 Aug 15;380(2):331-38.
24. Wiker HG, Harboe M. The antigen 85 complex: a major secretion product of Mycobacterium tuberculosis. Microbiol Rev. 1992 Dec;56(4):648-61.
25. Beatty WL, Russell DG. Identification of mycobacterial surface proteins released into subcellular compartments of infected macrophages. Infect Immun. 2000 Dec;68(12):6997-7002.
26. Armitige LY, Jagannath C, Wanger AR, Norris SJ. Disruption of the genes encoding antigen 85A and antigen 85B of Mycobacterium tuberculosis H37Rv: effect on growth in culture and in macrophages. Infect Immun. 2000 Feb;68(2):767-78.
27. Ojha AK, Trivelli X, Guerardel Y, Kremer L, Hatfull GF. Enzymatic hydrolysis of trehalose dimycolate releases free mycolic acids during mycobacterial growth in biofilms. J Biol Chem. 2010 Jun 4;285(23):17380-89.
28. Parker SK, Curtin KM, Vasil ML. Purification and characterization of mycobacterial phospholipase A: an activity associated with mycobacterial cutinase. J Bacteriol. 2007 Jun;189(11):4153-60.
29. Chan J, Xing Y, Magliozzo RS, Bloom BR. Killing of virulent Mycobacterium tuberculosis by reactive nitro-gen intermediates produced by activated murine macrophages. J Exp Med. 1992 Apr 1;175(4):1111-22.
30. Elamin AA, Stehr M, Spallek R, Rohde M, Singh M. The Mycobacterium tuberculosis Ag85A is a novel diacylglycerol acyltransferase involved in lipid body formation. Mol Microbiol. 2011 Sep;81(6):1577-92.
31. Crowe LM, Spargo BJ, Ioneda T, Beaman BL, Crowe JH. Interaction of cord factor (alpha, alpha′-trehalose-6,6′-dimycolate) with phospholipids. Biochim Biophys Acta. 1994 Aug 24;1194(1):53-60.
32. Hunter RL, Olsen M, Jagannath C, Actor JK. Trehalose 6,6′-dimycolate and lipid in the pathogenesis of caseating granulomas of tuberculosis in mice. Am J Pathol. 2006 Apr;168(4):1249-61.
33. Indrigo J, Hunter RL, Jr., Actor JK. Influence of treha-lose 6,6′-dimycolate (TDM) during mycobacterial infection of bone marrow macrophages. Microbiology. 2002 Jul;148(Pt 7):1991-98.
34. Sugawara I, Udagawa T, Yamada H. Rat neutrophils prevent the development of tuberculosis. Infect Immun. 2004 Mar;72(3):1804-6.
35. Spargo BJ, Crowe LM, Ioneda T, Beaman BL, Crowe JH. Cord factor (alpha,alpha-trehalose 6,6′-dimycolate) inhibits fusion between phospholipid vesicles. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):737-40.
36. Rajni, Rao N, Meena LS. Biosynthesis and virulent be-havior of lipids produced by Mycobacterium tuberculosis: LAM and cord factor: an overview. Biotechnol Res Int. 2011;2011:274693.
37. Silva CL, Faccioli LH. Tumor necrosis factor (cachectin) mediates induction of cachexia by cord factor from mycobacteria. Infect Immun. 1988 Dec;56(12):3067-71.
38. Korf J, Stoltz A, Verschoor J, De Baetselier P, Grooten J. The Mycobacterium tuberculosis cell wall component mycolic acid elicits pathogen-associated host innate immune responses. Eur J Immunol. 2005 Mar;35(3):890-900.
39. Nishizawa M, Yamamoto H, Imagawa H, Barbier-Chas-sefiere V, Petit E, Azuma I, Papy-Garcia D. Efficient syntheses of a series of trehalose dimycolate (TDM)/trehalose dicorynomycolate (TDCM) analogues and their interleukin-6 level enhancement activity in mice sera. J Org Chem. 2007 Mar 2;72(5):1627-33.
40. Underhill DM, Gantner B. Integration of Toll-like receptor and phagocytic signaling for tailored immunity. Microbes Infect. 2004 Dec;6(15):1368-73.
41. Welsh KJ, Abbott AN, Hwang SA, Indrigo J, Armitige LY, Blackburn MR, Hunter RL Jr, Actor JK. A role for tumour necrosis factor-alpha, complement C5 and interleukin-6 in the initiation and development of the mycobacterial cord factor trehalose 6,6′-dimycolate induced granulomatous response. Microbiology. 2008 Jun;154(Pt 6):1813-24.
42. Algood HM, Lin PL, Yankura D, Jones A, Chan J, Flynn JL. TNF influences chemokine expression of macro-phages in vitro and that of CD11b+ cells in vivo during Mycobacterium tuberculosis infection. J Immunol. 2004 Jun 1;172(11):6846-57.
43. Perez RL, Roman J, Roser S, Little C, Olsen M, Indrigo J, Hunter RL, Actor JK. Cytokine message and protein expression during lung granuloma formation and resolution induced by the mycobacterial cord factor trehalose6,6′-dimycolate. J Interferon Cytokine Res. 2000 Sep;20(9):795-804.
44. Appelberg R, Castro AG, Pedrosa J, Minoprio P. Role of interleukin-6 in the induction of protective T cells during mycobacterial infections in mice. Immunology. 1994 Jul;82(3):361-64.
45. Kastelein RA, Hunter CA, Cua DJ. Discovery and biology of IL-23 and IL-27: related but functionally distinct regulators of inflammation. Annu Rev Immunol. 2007;25:221-42.
46. Saijo S, Ikeda S, Yamabe K, Kakuta S, Ishigame H, Akitsu A, Fujikado N, Kusaka T, Kubo S, Chung SH, Komatsu R, Miura N, Adachi Y, Ohno N, Shibuya K, Yamamoto N, Kawakami K, Yamasaki S, Saito T, Akira S, Iwakura Y. Dectin-2 recognition of alpha-mannans and induction of Th17 cell differentiation is essential for host defense against Candida albicans. Immunity. 2010 May 28;32(5):681-91.
47. Sakai Y, Uchida K, Nakayama H. Histopathological features and expression profiles of cytokines, chemokines and SOCS family proteins in trehalose 6,6′-dimycolateinduced granulomatous lesions. Inflamm Res. 2011 Apr;60(4):371-78.
48. Gross V, Andus T. Human recombinant C5a enhances lipopolysaccharide-induced synthesis of interleu-kin-6 by human monocytes. Eur J Clin Invest. 1992 Apr;22(4):271-76.
49. Karp CL, Wills-Karp M. Complement and IL-12: yin and yang. Microbes Infect. 2001 Feb;3(2):109-19.
50. Borders CW, Courtney A, Ronen K, Pilar La-hoz Laborde M, Guidry TV, Hwang SA, Olsen M, Hunter RL Jr, Hollmann TJ, Wetsel RA, Actor JK. Requisite role for complement C5 and the C5a receptor in granulomatous response to mycobacterial glycolipid trehalose 6,6′-dimycolate. Scand J Immunol. 2005 Aug;62(2):123-30.
51. Yamasaki S IE, Sakuma M, Hara H, Ogata K, Saito T. Mincle is an ITAM-coupled activating receptor that senses damaged cells. Nat Immunol. 2008 Sep 7;9(10):1179-88.
52. Kleinnijenhuis J, Oosting M, Joosten LA, Netea MG, Van Crevel R. Innate immune recognition of Mycobacterium tuberculosis. Clin Dev Immunol. 2011;2011:405310.
53. Jo EK. Mycobacterial interaction with innate receptors: TLRs, C-type lectins, and NLRs. Curr Opin Infect Dis. 2008 Jun;21(3):279-86.
54. Geisel RE, Sakamoto K, Russell DG, Rhoades ER. In vivo activity of released cell wall lipids of Mycobacterium bovis bacillus Calmette-Guerin is due principally to trehalose mycolates. J Immunol. 2005 Apr 15;174(8):5007-15.
55. Matsunaga I, Moody DB. Mincle is a long sought receptor for mycobacterial cord factor. J Exp Med. 2009 Dec 21;206(13):2865-68.
56. Ishikawa E, Ishikawa T, Morita YS, Toyonaga K, Yamada H, Takeuchi O, Takeuchi O, Kinoshita T, Akira S, Yoshikai Y, Yamasaki S. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle. J Exp Med. 2009 Dec 21;206(13):2879-88.
57. Lee WB, Kang JS, Yan JJ, Lee MS, Jeon BY, Cho SN, Kim YJ. Neutrophils promote mycobacterial trehalose dimycolate-induced lung inflammation via the Mincle pathway. PLoS Pathog. 2012 Apr;8(4):e1002614.
58. Matsumoto M, Tanaka T, Kaisho T, Sanjo H, Cope-land NG, Gilbert DJ, Jenkins NA, Akira S. A novel LPS-inducible C-type lectin is a transcriptional target of NF-IL6 in macrophages. J Immunol. 1999 Nov 1;163(9):5039-48.
59. Colonna M. All roads lead to CARD9. Nat Immunol. 2007 Jun;8(6):554-55.