The estrogenic effects of benzylparaben at low doses based on uterotrophic assay in immature SD rats

Food and Chemical Toxicology

Volumn 53, Issue , 2013, Pages 69-74

  Hu, Ying ^a   Zhang, Zhaobin ^a   Sun, Libei ^a   Zhu, Desheng ^a   Liu, Qingchun ^b   Jiao, Jian ^a   Li, Jun ^a   Qi, Mingwen ^a  

^a PEKING UNIVERSITY   (China)

^b GENERAL HOSPITAL OF CHINESE PEOPLE'S ARMED POLICE FORCES   (China)

Author keywords

BAP; Benzylparaben; Bw; BzP; DMSO; E2; EDCs; Endocrine disrupting chemicals; Estrogenicity; FDA; GST; HER ; JECFA; LOED; Parabens; PMF; PND; RMSE; SD; SE; Uterotrophic effect

Indexed keywords

BENZYL PARABEN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA;

ANIMAL EXPERIMENT; ARTICLE; COMPUTER MODEL; CONCENTRATION RESPONSE; CONTROLLED STUDY; ESTROGEN ACTIVITY; FEMALE; FOOD INTAKE; FOOD POISONING; IMMATURITY; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DOCKING; NONHUMAN; RAT; RISK ASSESSMENT; SENSITIVITY ANALYSIS; TOXICITY TESTING; UTERUS WEIGHT;

ANIMALS; BIOLOGICAL ASSAY; COSMETICS; DOSE-RESPONSE RELATIONSHIP, DRUG; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; ESTROGENS; FEMALE; FOOD ADDITIVES; ORGAN SIZE; PARABENS; RATS; RATS, SPRAGUE-DAWLEY; RATS, WISTAR; UTERUS;

RATTUS; RATTUS NORVEGICUS;

EID: 84871588347     PISSN: 02786915     EISSN: 18736351     Source Type: Journal    
DOI: 10.1016/j.fct.2012.11.043     Document Type: Article

References (33)

1. Brouwers M.M., Besselink H., Bretveld R.W., Anzion R., Scheepers P.T.J., Brouwer A., Roeleveld N. Estrogenic and androgenic activities in total plasma measured with reporter-gene bioassays: relevant exposure measures for endocrine disruptors in epidemiologic studies?. Environ. Int. 2011, 37:557-564.
2. Cao Q.M., Yu Q.M., Connell D.W. Fate simulation and risk assessment of endocrine disrupting chemicals in a reservoir receiving recycled wastewater. Sci. Total Environ. 2010, 408:6243-6250.
3. Colborn T., Saal F.S.V., Soto A.M. Developmental effects of endocrine-disrupting chemicals in wildlife and humans. Environ. Health Perspect. 1993, 101:378-384.
4. Darbre P.D., Byford J.R., Shaw L.E., Hall S., Coldham N.G., Pope G.S., Sauer M.J. Oestrogenic activity of benzylparaben. J. Appl. Toxicol. 2003, 23:43-51.
5. Diamanti-Kandarakis E., Bourguignon J.-P., Giudice L.C., Hauser R., Prins G.S., Soto A.M., Zoeller R.T., Gore A.C. Endocrine-disrupting chemicals: an Endocrine Society scientific statement. Endocr. Rev. 2009, 30:293-342.
6. Diel P., Schmidt S., Vollmer G., Janning P., Upmeier A., Michna H., Blot H.M., Degan G.H. Comparative response of three rat strains (DA/Han, Sprague Dawley and Wistar) to treatment with environmental estrogens. Arch. Toxicol. 2004, 78:183-193.
7. Elobeid M.A., Allison D.B. Putative environmental-endocrine disruptors and obesity: a review. Curr. Opin. Endocrinol. Diab. Obes. 2008, 15:403-408.
8. Enewold L., Zhu K., Ron E., Marrogi A.J., Stojadinovic A., Peoples G.E., Devesa S.S. Rising thyroid cancer incidence in the United States by demographic and tumor characteristics, 1980-2005. Cancer Epidem. Biomar. 2009, 18:784-791.
9. FDA (U.S. Food and Drug Administration). 1999. Guideline 3, part 2: Guideline for toxicological testing, http://www.fda.gov.
10. Federal Register Code of Federal Regulation. Fed. Reg. 2004, 21(184):1490-1670.
11. Frederiksen H., Jorgensen N., Andersson A.-M. Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography- tandem mass spectrometry (LC-MS/MS). J. Expo. Sci. Environ. Epidemiol. 2011, 21:262-271.
12. Geara-Matta, D., Lorgeoux, C., Rocher, V., El Samrani, A., Chebbo, G., Moilleron, R., 2011. Occurrence of endocrine disruptors in wastewater from combined sewers in Paris and Beirut: what about parabens? 12th International Conference on Urban Drainage, Porto Alegre/Brazil. 11-16.
13. Grun F., Blumberg B. Endocrine disrupters as obesogens. Mol. Cell Endocrinol. 2009, 304:19-29.
14. Hossaini A., Larsen J.J., Larsen J.C. Lack of oestrogenic effect of food preservatives (parabens) in uterotrophic assays. Food Chem. Toxicol. 2000, 38:319-323.
15. Hu W.Y., Shi G.B., Lam H.M., Hu D.P., Ho S.M., Madueka I.C., Kajdacsy-Balla A., Prins G.S. Estrogen-initiated transformation of prostate epithelium derived from normal human prostate stem-progenitor cells. Endocrinology 2011, 152:2150-2163.
16. Huyghe E., Matsuda T., Thonneau P. Increasing incidence of testicular cancer worldwide: a review. J. Urol. 2003, 170:5-11.
17. JECFA (Joint FAO/WHO Expert Committee on Food Additives), 1999. Fifty-second Meeting: Rome, pp. 1-24.
18. Kanayama T., Mamiya S., Nishihara T., Nishikawa J. Basis of a high through put method for nuclear receptor ligands. J. Biochem. 2003, 133:791-797.
19. Kiss G., Allen N.W. Automated docking of estrogens and SERMs into an estrogen receptor alpha and beta isoform using the PMF forcefield and the Lamarckian genetic algorithm. Theor. Chem. Acc. 2007, 117:305-314.
20. Laws S.C., Carey S.A., Ferrell J.M., Bodman G.J., Cooper R.L. Estrogenic activity of octylphenol, nonylphenol, bisphenol A and methoxychlor in rats. Toxicol. Sci. 2000, 54:154-167.
21. Lemini C., Jaimez R., Avila M.E., Franco Y., Larrea F., Lemus A.E. In vivo and in vitro estrogen bioactivities of alkyl parabens. Toxicol. Indust. Health 2003, 19:69-79.
22. Marx-Stoelting P., Pfeil R., Solecki R., Ulbrich B., Grote K., Ritz V., Banasiak U., Heinrich-Hirsch B., Moeller T. Assessment strategies and decision criteria for pesticides with endocrine disrupting properties relevant to humans. Reprod. Toxicol. 2011, 31:574-584.
23. Meeker J.D. Exposure to environmental endocrine disrupting compounds and men's health. Maturitas 2010, 66:236-241.
24. OECD, 2007. Uterotrophic Bioassay in Rodents: a short-term screening test for oestrogenic properties (OECD Test Guideline 440, adopted 16 October 2007). http://www.epa.gov/endo/pubs/uterotrophic_OECD_guideline.pdf.
25. Routledge E.J., Parker J., Odum J., Ashby J., Sumpter J.P. Some alkyl hydroxyl benzoate preservatives (Parabens) are estrogenic. Toxicol. Appl. Pharm. 1998, 153:12-19.
26. Schell L.M., Gallo M.V. Relationships of putative endocrine disruptors to human sexual maturation and thyroid activity in youth. Physiol. Behav. 2010, 99:246-253.
27. Schug T.T., Janesick A., Blumberg B., Heindel J.J. Endocrine disrupting chemicals and disease susceptibility. J. Steroid. Biochem. 2011, 127:204-215.
28. Soto A.M., Sonnenschein C. Environmental causes of cancer: endocrine disruptors as carcinogens. Nat. Rev. Endocrinol. 2010, 6:364-371.
29. Swan S.H., Main K.M., Liu F., Stewart S.L., Kruse R.L., Calafat A.M., Mao C.S., Redmon J.B., Ternand C.L., Sullivan S., Teague J.L. Decrease in anogenital distance among male infants with prenatal phthalate exposure. Environ. Health Perspect. 2005, 113:1056-1061.
30. Thuy T.B.V., Eui-Bae J. An evaluation of estrogenic activity of parabens using uterine calbindin-D9k gene in an immature rat model. Toxicol. Sci. 2009, 112:68-77.
31. Vom Saal F.S., Nagel S.C., Coe B.L., Angle B.M., Taylor J.A. The estrogenic endocrine disrupting chemical bisphenol A (BPA) and obesity. Mol. Cell Endocrinol. 2012, 354:74-84.
32. Zama A.M., Uzumcu M. Epigenetic effects of endocrine-disrupting chemicals on female reproduction: an ovarian perspective. Front. Neuroendocrin. 2010, 31:420-439.
33. Zhang Z.B., Jia C.X., Hu Y., Sun L.B., Jiao J., Zhao L., Zhu D.S., Li J., Tian Y.L., Bai H.C., Li R.B., Hu J.Y. The estrogenic potential of salicylate esters and their possible risk in foods and cosmetics. Toxicol. Lett. 2012, 209:146-153.