메뉴 건너뛰기




Volumn 4, Issue 4, 2012, Pages 1036-1049

Do non-genomically encoded fusion transcripts cause recurrent chromosomal translocations?

Author keywords

Genetic rearrangements; Leukemia; Premature transcript termination; Recurrent chromosomal translocations; RNA templated DNA repair; Solid tumors

Indexed keywords

MESSENGER RNA; MIXED LINEAGE LEUKEMIA PROTEIN; NUCLEOPORIN 98; TRANSCRIPTION FACTOR ETV6; TRANSCRIPTION FACTOR RUNX1;

EID: 84871556819     PISSN: None     EISSN: 20726694     Source Type: Journal    
DOI: 10.3390/cancers4041036     Document Type: Article
Times cited : (14)

References (33)
  • 1
    • 0032506701 scopus 로고    scopus 로고
    • Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): The DNA damage-repair model of translocation
    • Reichel, M.; Gillert, E.; Nilson, I.; Siegler, G.; Greil, J.; Fey, G.H.; Marschalek, R. Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): The DNA damage-repair model of translocation. Oncogene 1998, 17, 3035-3044.
    • (1998) Oncogene , vol.17 , pp. 3035-3044
    • Reichel, M.1    Gillert, E.2    Nilson, I.3    Siegler, G.4    Greil, J.5    Fey, G.H.6    Marschalek, R.7
  • 2
    • 0032519826 scopus 로고    scopus 로고
    • Detection of unique ALL1 (MLL) fusion transcripts in normal human bone marrow and blood: Distinct origin of normal versus leukemic ALL1 fusion transcripts
    • Marcucci, G.; Strout, M.P.; Bloomfield, C.D.; Caligiuri, M.A. Detection of unique ALL1 (MLL) fusion transcripts in normal human bone marrow and blood: Distinct origin of normal versus leukemic ALL1 fusion transcripts. Cancer Res. 1998, 58, 790-793.
    • (1998) Cancer Res , vol.58 , pp. 790-793
    • Marcucci, G.1    Strout, M.P.2    Bloomfield, C.D.3    Caligiuri, M.A.4
  • 4
    • 0028786297 scopus 로고
    • Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals
    • Biernaux, C.; Loos, M.; Sels, A.; Huez, G.; Stryckmans, P. Detection of major bcr-abl gene expression at a very low level in blood cells of some healthy individuals. Blood 1995, 86, 3118-3122.
    • (1995) Blood , vol.86 , pp. 3118-3122
    • Biernaux, C.1    Loos, M.2    Sels, A.3    Huez, G.4    Stryckmans, P.5
  • 5
    • 0032211172 scopus 로고    scopus 로고
    • The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease
    • Bose, S.; Deininger, M.; Gora-Tybor, J.; Goldman, J.M.; Melo, J.V. The presence of typical and atypical BCR-ABL fusion genes in leukocytes of normal individuals: Biologic significance and implications for the assessment of minimal residual disease. Blood 1998, 92, 3362-3367.
    • (1998) Blood , vol.92 , pp. 3362-3367
    • Bose, S.1    Deininger, M.2    Gora-Tybor, J.3    Goldman, J.M.4    Melo, J.V.5
  • 6
    • 0035254207 scopus 로고    scopus 로고
    • Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals
    • Eguchi-Ishimae, M.; Eguchi, M.; Ishii, E.; Miyazaki, S.; Ueda, K.; Kamada, N.; Mizutani, S. Breakage and fusion of the TEL (ETV6) gene in immature B lymphocytes induced by apoptogenic signals. Blood 2001, 97, 737-743.
    • (2001) Blood , vol.97 , pp. 737-743
    • Eguchi-Ishimae, M.1    Eguchi, M.2    Ishii, E.3    Miyazaki, S.4    Ueda, K.5    Kamada, N.6    Mizutani, S.7
  • 8
    • 0031811607 scopus 로고    scopus 로고
    • Characterization of t(2;5) reciprocal transcripts and genomic breakpoints in CD30+ cutaneous lymphoproliferations
    • Beylot-Barry, M.; Groppi, A.; Vergier, B.; Pulford, K.; Merlio, J.P. Characterization of t(2;5) reciprocal transcripts and genomic breakpoints in CD30+ cutaneous lymphoproliferations. Blood 1998, 91, 4668-4676.
    • (1998) Blood , vol.91 , pp. 4668-4676
    • Beylot-Barry, M.1    Groppi, A.2    Vergier, B.3    Pulford, K.4    Merlio, J.P.5
  • 11
    • 84871586124 scopus 로고    scopus 로고
    • Premature transcript termination, trans-splicing and DNA repair: A vicious path to cancer
    • Kowarz, E.; Merkens, J.; Karas, M.; Dingermann, T.; Marschalek, R. Premature transcript termination, trans-splicing and DNA repair: A vicious path to cancer. Am. J. Blood Res. 2011, 1, 1-12.
    • (2011) Am. J. Blood Res , vol.1 , pp. 1-12
    • Kowarz, E.1    Merkens, J.2    Karas, M.3    Dingermann, T.4    Marschalek, R.5
  • 12
    • 0029890796 scopus 로고    scopus 로고
    • Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias
    • Nilson, I.; Löchner, K.; Siegler, G.; Greil, J.; Beck, J.D.; Fey, G.H.; Marschalek, R. Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias. Br. J. Haematol. 1996, 93, 966-972.
    • (1996) Br. J. Haematol , vol.93 , pp. 966-972
    • Nilson, I.1    Löchner, K.2    Siegler, G.3    Greil, J.4    Beck, J.D.5    Fey, G.H.6    Marschalek, R.7
  • 13
  • 14
    • 51149114001 scopus 로고    scopus 로고
    • A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells
    • Li, H.; Wang, J.; Mor, G.; Sklar, J. A neoplastic gene fusion mimics trans-splicing of RNAs in normal human cells. Science 2008, 321, 1357-1361.
    • (2008) Science , vol.321 , pp. 1357-1361
    • Li, H.1    Wang, J.2    Mor, G.3    Sklar, J.4
  • 15
    • 58549108212 scopus 로고    scopus 로고
    • Gene fusions and RNA trans-splicing in normal and neoplastic human cells
    • Li, H.; Wang, J.; Ma, X.; Sklar, J. Gene fusions and RNA trans-splicing in normal and neoplastic human cells. Cell Cycle 2009, 8, 218-222.
    • (2009) Cell Cycle , vol.8 , pp. 218-222
    • Li, H.1    Wang, J.2    Ma, X.3    Sklar, J.4
  • 16
    • 0034234515 scopus 로고    scopus 로고
    • DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis
    • Strissel, P.L.; Strick, R.; Tomek, R.J.; Roe, B.A.; Rowley, J.D.; Zeleznik-Le, N.J. DNA structural properties of AF9 are similar to MLL and could act as recombination hot spots resulting in MLL/AF9 translocations and leukemogenesis. Hum. Mol. Genet. 2000, 9, 1671-1679.
    • (2000) Hum. Mol. Genet , vol.9 , pp. 1671-1679
    • Strissel, P.L.1    Strick, R.2    Tomek, R.J.3    Roe, B.A.4    Rowley, J.D.5    Zeleznik-Le, N.J.6
  • 17
    • 0034956937 scopus 로고    scopus 로고
    • Breakpoints of t(4;11) translocations in the human MLL and AF4 genes in ALL patients are preferentially clustered outside of high-affinity matrix attachment regions
    • Hensel, J.P.; Gillert, E.; Fey, G.H.; Marschalek, R. Breakpoints of t(4;11) translocations in the human MLL and AF4 genes in ALL patients are preferentially clustered outside of high-affinity matrix attachment regions. J. Cell Biochem. 2001, 82, 299-309.
    • (2001) J. Cell Biochem , vol.82 , pp. 299-309
    • Hensel, J.P.1    Gillert, E.2    Fey, G.H.3    Marschalek, R.4
  • 18
    • 33646174518 scopus 로고    scopus 로고
    • Common chromatin structures at breakpoint cluster regions may lead to chromosomal translocations found in chronic and acute leukemias
    • Strick, R.; Zhang, Y.; Emmanuel, N.; Strissel, P.L. Common chromatin structures at breakpoint cluster regions may lead to chromosomal translocations found in chronic and acute leukemias. Hum. Genet. 2006, 119, 479-495.
    • (2006) Hum. Genet , vol.119 , pp. 479-495
    • Strick, R.1    Zhang, Y.2    Emmanuel, N.3    Strissel, P.L.4
  • 19
    • 0032533231 scopus 로고    scopus 로고
    • An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region
    • Strissel, P.L.; Strick, R.; Rowley, J.D.; Zeleznik-Le, N.J. An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region. Blood 1998, 92, 3793-3803.
    • (1998) Blood , vol.92 , pp. 3793-3803
    • Strissel, P.L.1    Strick, R.2    Rowley, J.D.3    Zeleznik-Le, N.J.4
  • 20
    • 0030012114 scopus 로고    scopus 로고
    • Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors
    • Aplan, P.D.; Chervinsky, D.S.; Stanulla, M.; Burhans, W.C. Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood 1996, 87, 2649-2658.
    • (1996) Blood , vol.87 , pp. 2649-2658
    • Aplan, P.D.1    Chervinsky, D.S.2    Stanulla, M.3    Burhans, W.C.4
  • 21
    • 0030976354 scopus 로고    scopus 로고
    • Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents
    • Nasr, F.; Macintyre, E.; Venuat, A.M.; Bayle, C.; Carde, P.; Ribrag, V. Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents. Leuk. Lymphoma 1997, 25, 399-401.
    • (1997) Leuk. Lymphoma , vol.25 , pp. 399-401
    • Nasr, F.1    Macintyre, E.2    Venuat, A.M.3    Bayle, C.4    Carde, P.5    Ribrag, V.6
  • 23
    • 0035056832 scopus 로고    scopus 로고
    • Leukemias related to treatment with DNA topoisomerase II inhibitors
    • Felix, C.A. Leukemias related to treatment with DNA topoisomerase II inhibitors. Med. Pediatr. Oncol. 2001, 36, 525-535.
    • (2001) Med. Pediatr. Oncol , vol.36 , pp. 525-535
    • Felix, C.A.1
  • 24
    • 0031011855 scopus 로고    scopus 로고
    • DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis
    • Stanulla, M.; Wang, J.; Chervinsky, D.S.; Thandla, S.; Aplan, P.D. DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Mol. Cell Biol. 1997, 17, 4070-4079.
    • (1997) Mol. Cell Biol , vol.17 , pp. 4070-4079
    • Stanulla, M.1    Wang, J.2    Chervinsky, D.S.3    Thandla, S.4    Aplan, P.D.5
  • 25
    • 0035360796 scopus 로고    scopus 로고
    • Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system
    • Betti, C.J.; Villalobos, M.J.; Diaz, M.O.; Vaughan, A.T. Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Res. 2001, 61, 4550-4555.
    • (2001) Cancer Res , vol.61 , pp. 4550-4555
    • Betti, C.J.1    Villalobos, M.J.2    Diaz, M.O.3    Vaughan, A.T.4
  • 26
    • 0035888653 scopus 로고    scopus 로고
    • Mechanisms of MLL gene rearrangement: Site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context
    • Stanulla, M.; Chhalliyil, P.; Wang, J.; Jani-Sait, S.N.; Aplan, P.D. Mechanisms of MLL gene rearrangement: Site-specific DNA cleavage within the breakpoint cluster region is independent of chromosomal context. Hum. Mol. Genet. 2001, 10, 2481-2491.
    • (2001) Hum. Mol. Genet , vol.10 , pp. 2481-2491
    • Stanulla, M.1    Chhalliyil, P.2    Wang, J.3    Jani-Sait, S.N.4    Aplan, P.D.5
  • 27
    • 0035943687 scopus 로고    scopus 로고
    • Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis
    • Sim, S.P.; Liu, L.F. Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis. J. Biol. Chem. 2001, 276, 31590-31595.
    • (2001) J. Biol. Chem , vol.276 , pp. 31590-31595
    • Sim, S.P.1    Liu, L.F.2
  • 30
    • 44849108310 scopus 로고    scopus 로고
    • RNA-mediated DNA modifications and RNA-templated DNA repair
    • Storici, F. RNA-mediated DNA modifications and RNA-templated DNA repair. Curr. Opin. Mol. Ther. 2008, 10, 224-230.
    • (2008) Curr. Opin. Mol. Ther , vol.10 , pp. 224-230
    • Storici, F.1
  • 32
    • 70249129382 scopus 로고    scopus 로고
    • Implications of chimaeric non-co-linear transcripts
    • Gingeras, T.R. Implications of chimaeric non-co-linear transcripts. Nature 2009, 461, 206-211.
    • (2009) Nature , vol.461 , pp. 206-211
    • Gingeras, T.R.1
  • 33
    • 84871583857 scopus 로고    scopus 로고
    • Trans-splicing in higher eukaryotes: Implications for cancer development?
    • Zaphiropoulos, P.G. Trans-splicing in higher eukaryotes: Implications for cancer development? Front. Genet. 2011, 2, 92.
    • (2011) Front. Genet , vol.2 , pp. 92
    • Zaphiropoulos, P.G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.