Rare ADH variant constellations are specific for alcohol dependence

Alcohol and Alcoholism

Volumn 48, Issue 1, 2013, Pages 9-14

  Zuo, Lingjun ^a   Zhang, Heping ^a   Malison, Robert T ^a   Li, Chiang Shan R ^a   Zhang, Xiang Yang ^b   Wang, Fei ^a   Lu, Lingeng ^a   Lu, Lin ^c   Wang, Xiaoping ^d   Krystal, John H ^a,e,f   Zhang, Fengyu ^g   Deng, Hong Wen ^h   Luo, Xingguang ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b BAYLOR COLLEGE OF MEDICINE   (United States)

^c PEKING UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY   (China)

^e YALE NEW HAVEN HOSPITAL   (United States)

^f VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^g LIEBER INSTITUTE FOR BRAIN DEVELOPMENT   (United States)

^h TULANE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1B; ALCOHOL DEHYDROGENASE 1C; ALCOHOL DEHYDROGENASE 4; ALCOHOL DEHYDROGENASE 5; ALCOHOL DEHYDROGENASE 6; ALCOHOL DEHYDROGENASE 7; UNCLASSIFIED DRUG;

AFRICAN AMERICAN; ALCOHOLISM; AMYOTROPHIC LATERAL SCLEROSIS; ARTICLE; ATTENTION DEFICIT DISORDER; AUTISM; BIPOLAR DISORDER; BRAIN ISCHEMIA; EUROPEAN AMERICAN; FEMALE; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR DEPRESSION; MALE; PARKINSON DISEASE; PHENOTYPE; PRIORITY JOURNAL; SCHIZOPHRENIA; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; AFRICAN AMERICANS; AGED; AGED, 80 AND OVER; ALCOHOL DEHYDROGENASE; ALCOHOLISM; AUSTRALIA; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; EUROPEAN CONTINENTAL ANCESTRY GROUP; FEMALE; GENETIC VARIATION; HUMANS; MALE; MIDDLE AGED; MULTIGENE FAMILY;

EID: 84871532709     PISSN: 07350414     EISSN: 14643502     Source Type: Journal    
DOI: 10.1093/alcalc/ags104     Document Type: Article

References (29)

1. American Psychiatric Association. (1994) Diagnostic and Statistical Manual of Mental Disorders. Washington, DC: American Psychiatric Press.
2. Asimit JL, Day-Williams AG, Morris AP et al. (2012) ARIEL and AMELIA: testing for an accumulation of rare variants using next-generation sequencing data. Hum Hered 73:84-94.
3. Bierut LJ, Agrawal A, Bucholz KK et al. (2010) A genome-wide association study of alcohol dependence. Proc Natl Acad Sci USA 107:5082-7.
4. Boomsma DI, Willemsen G, Sullivan PF et al. (2008)Genome-wide association of major depression: description of samples for the GAIN Major Depressive Disorder Study: NTR and NESDA biobank projects. Eur J Hum Genet 16:335-42.
5. Bucholz KK, Cadoret R, Cloninger CR et al. (1994) A new, semistructured psychiatric interview for use in genetic linkage studies: a report on the reliability of the SSAGA. J Stud Alcohol 55:149-58.
6. Buervenich S, Sydow O, Carmine A et al. (2000) Alcohol dehydrogenase alleles in Parkinson's disease. Mov Disord 15:813-8.
7. Buervenich S, Carmine A, Galter D et al. (2005) A rare truncating mutation in ADH1C (G78Stop) shows significant association with Parkinson disease in a large international sample. Arch Neurol 62:74-8.
8. Dickson SP, Wang K, Krantz I et al. (2010) Rare variants create synthetic genome-wide associations. PLoS Biol 8:e1000294.
9. Edenberg HJ, Koller DL, Xuei X et al. (2010) Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcohol Clin Exp Res 34:840-52.
10. Frank J, Cichon S, Treutlein J et al. (2012) Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster. Addict Biol 17:171-80.
11. Grant BF, Stinson FS, Dawson DA et al. (2004) Prevalence and cooccurrence of substance use disorders and independent mood
12. Heath AC, Whitfield JB, Martin NG et al. (2011) A quantitative-trait genome-wide association study of alcoholism risk in the community:findings and implications. Biol Psychiatry 70:513-8.
13. Horvath S, Xu X, Laird NM. (2001) The family based association test method: strategies for studying general genotype-phenotype associations. Eur J Hum Genet 9:301-6.
14. Howie BN, Donnelly P, Marchini J. (2009) A flexible and accurate genotype imputation method for the next generation of genomewide association studies. PLoS Genet 5:e1000529.
15. Kessler RC, Nelson CB, McGonagle KA et al. (1996) The epidemiology of co-occurring addictive and mental disorders: implications for prevention and service utilization. Am J Orthopsychiatry 66:17-31.
16. Li J, Ji L. (2005) Adjusting multiple testing in multilocus analyses using the eigenvalues of a correlation matrix. Heredity (Edinb)95:221-7.
17. Lin DY, Tang ZZ. (2011) A general framework for detecting disease associations with rare variants in sequencing studies. Am J Hum Genet 89:354-67.
18. Luo X, Kranzler HR, Zuo L et al. (2006) Diplotype trend regression analysis of the ADH gene cluster and the ALDH2 gene: multiple significant associations with alcohol dependence. Am J Hum Genet 78:973-87.
19. Luo X, Kranzler HR, Zuo L et al. (2008) ADH7 variation modulates extraversion and conscientiousness in substance-dependent subjects.Am J Med Genet B Neuropsychiatr Genet 147B:179-86.
20. Price AL, Patterson NJ, Plenge RM et al. (2006) Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet 38:904-9.
21. Purcell S, Neale B, Todd-Brown K et al. (2007) PLINK: a tool set for whole-genome association and population-based linkage analyses.Am J Hum Genet 81:559-75.
22. Regier DA, Farmer ME, Rae DS et al. (1990) Comorbidity of mental disorders with alcohol and other drug abuse. Results from the Epidemiologic Catchment Area (ECA) Study. J Am Med Assoc 264
23. Satre MA, Zgombic-Knight M, Duester G. (1994) The complete structure of human class IV alcohol dehydrogenase (retinol dehydrogenase)determined from the ADH7 gene. J Biol Chem 269:15606-12.
24. Shmueli O, Horn-Saban S, Chalifa-Caspi V et al. (2003) GeneNote:whole genome expression profiles in normal human tissues. C R Biol 326:1067-72.
25. Suzuki Y, Fujisawa M, Ando F et al. (2004) Alcohol dehydrogenase 2 variant is associated with cerebral infarction and lacunae.Neurology 63:1711-13.
26. Yanai I, Benjamin H, Shmoish M et al. (2005) Genome-wide midrange transcription profiles reveal expression level relationships in human tissue specification. Bioinformatics 21:650-9.
27. Yasunami M, Chen CS, Yoshida A. (1991) A human alcohol dehydrogenase gene (ADH6) encoding an additional class of isozyme. Proc Natl Acad Sci USA 88:7610-4.
28. Zuo L, Gelernter J, Zhang CK et al. (2011a) Genomewide association study of alcohol dependence implicates KIAA0040 on chromosome 1q. Neuropsychopharmacology 37:557-66.
29. Zuo L, Zhang CK, Wang F et al. (2011b) A novel, functional and replicable risk gene region for alcohol dependence identified by genome-wide association study. PLoS ONE 6:e26726.