Association of nicotine dependence susceptibility gene, CHRNA5, with Parkinson's disease age at onset: Gene and smoking status interaction

Parkinsonism and Related Disorders

Volumn 19, Issue 1, 2013, Pages 72-76

  Greenbaum, Lior ^a   Rigbi, Amihai ^a   Lipshtat, Nurit ^a   Cilia, Roberto ^b   Tesei, Silvana ^b   Asselta, Rosanna ^c   Djaldetti, Ruth ^d,e   Goldwurm, Stefano ^b   Lerer, Bernard ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b PARKINSON INSTITUTE   (Italy)

^c UNIVERSITY OF MILAN   (Italy)

^d RABIN MEDICAL CENTER   (Israel)

^e TEL AVIV UNIVERSITY   (Israel)

Author keywords

Age at onset; CHRNA5; Gene environment interaction; Nicotine dependence; Parkinson's disease

Indexed keywords

CHRNA5 PROTEIN; NICOTINE; NICOTINIC RECEPTOR; UNCLASSIFIED DRUG;

ADULT; AGED; ALLELE; ARTICLE; CHRNA5 GENE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE COURSE; DOMINANT INHERITANCE; FEMALE; GENE; GENE CLUSTER; GENETIC ASSOCIATION; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GENOTYPE; GENOTYPE ENVIRONMENT INTERACTION; HETEROZYGOTE; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; ONSET AGE; PARKINSON DISEASE; PILOT STUDY; PRIORITY JOURNAL; SINGLE NUCLEOTIDE POLYMORPHISM; SMOKING; TOBACCO DEPENDENCE;

AGE OF ONSET; AGED; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; PARKINSON DISEASE; POLYMORPHISM, SINGLE NUCLEOTIDE; RECEPTORS, NICOTINIC; RISK; SMOKING; TOBACCO USE DISORDER;

EID: 84871526790     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2012.07.007     Document Type: Article

References (36)

1. Sugita M., Izuno T., Tatemichi M., Otahara Y. Meta-analysis for epidemiologic studies on the relationship between smoking and Parkinson's disease. J Epidemiol 2001, 11:87-94.
2. Allam M.F., Campbell M.J., Hofman A., Del Castillo A.S., Fernández-Crehuet Navajas R. Smoking and Parkinson's disease: systematic review of prospective studies. Mov Disord 2004, 19:614-621.
3. Thacker E.L., O'Reilly E.J., Weisskopf M.G., Chen H., Schwarzschild M.A., McCullough M.L., et al. Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology 2007, 68:764-768.
4. Quik M., Bordia T., O'Leary K. Nicotinic receptors as CNS targets for Parkinson's disease. Biochem Pharmacol 2007, 74:1224-1234.
5. Meshul C.K., Kamel D., Moore C., Kay T.S., Krentz L. Nicotine alters striatal glutamate function and decreases the apomorphine-induced contralateral rotations in 6-OHDA-lesioned rats. Exp Neurol 2002, 175:257-274.
6. Hancock D.B., Martin E.R., Fujiwara K., Stacy M.A., Scott B.L., Stajich J.M., et al. NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. Ann Neurol 2006, 60:366-373.
7. McCulloch C.C., Kay D.M., Factor S.A., Samii A., Nutt J.G., Higgins D.S., et al. Exploring gene-environment interactions in Parkinson's disease. Hum Genet 2008, 123:257-265.
8. De Palma G., Dick F.D., Calzetti S., Scott N.W., Prescott G.J., Osborne A., et al. A case-control study of Parkinson's disease and tobacco use: gene-tobacco interactions. Mov Disord 2010, 25:912-919.
9. Gu Z., Feng X., Dong X., Chan P. Smoking, genes encoding dopamine pathway and risk for Parkinson's disease. Neurosci Lett 2010, 482:31-34.
10. De Reuck J., De Weweire M., Van Maele G., Santens P. Comparison of age of onset and development of motor complications between smokers and non-smokers in Parkinson's disease. J Neurol Sci 2005, 231:35-39.
11. Kandinov B., Giladi N., Korczyn A.D. Smoking and tea consumption delay onset of Parkinson's disease. Parkinsonism Relat Disord 2009, 15:41-46.
12. Wilk J.B., Lash T.L. Risk factor studies of age-at-onset in a sample ascertained for Parkinson disease affected sibling pairs: a cautionary tale. Emerg Themes Epidemiol 2007, 4(4):1.
13. Greenbaum L., Lerer B. Differential contribution of genetic variation in multiple brain nicotinic cholinergic receptors to nicotine dependence: recent progress and emerging open questions. Mol Psychiatry 2009, 14:912-945.
14. Saccone S.F., Hinrichs A.L., Saccone N.L., Chase G.A., Konvicka K., Madden P.A., et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 2007, 16:36-49.
15. Thorgeirsson T.E., Geller F., Sulem P., Rafnar T., Wiste A., Magnusson K.P., et al. A variant associated with nicotine dependence, lung cancer and peripheral arterial disease. Nature 2008, 452:638-642.
16. Berrettini W.H., Doyle G.A. The CHRNA5-A3-B4 gene cluster in nicotine addiction. Mol Psychiatry 4 Oct 2011, published on line. 10.1038/mp.2011.122.
17. Saccone N.L., Culverhouse R.C., Schwantes-An T.-H., Cannon D.S., Chen X., Cichon S., et al. Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD. PLoS Genet 2010, 6(8):e1001053. 10.1371/journal.pgen.1001053.
18. Amos C.I., Wu X., Broderick P., Gorlov I.P., Gu J., Eisen T., et al. Genomewide association scan of tag SNPs identifies a susceptibility locus for lung cancer at 15q25.1. Nat Genet 2008, 40:616-622.
19. Azam L., Winzer-Serhan U.H., Chen Y., Leslie F.M. Expression of neuronal nicotinic acetylcholine receptor subunit mRNAs within midbrain dopamine neurons. J Comp Neurol 2002, 444:260-274.
20. Zoli M., Moretti M., Zanardi A., McIntosh J.M., Clementi F., Gotti C. Identification of the nicotinic receptor subtypes expressed on dopaminergic terminals in the rat striatum. J Neurosci 2002, 22:8785-8789.
21. Gao J., Xu H., Weinberg C., Huang X., Park Y., Hollenbeck A., et al. An exploratory study on the CHRNA3-CHRNA5-CHRNB4 cluster, smoking, and Parkinson's disease. Neurodegener Dis 2011, 8:296-299.
22. Goldwurm S., Zini M., Di Fonzo A., De Gaspari D., Siri C., Simons E.J., et al. LRRK2 G2019S mutation and Parkinson's disease: a clinical, neuropsychological and neuropsychiatric study in a large Italian sample. Parkinsonism Relat Disord 2006, 12:410-419.
23. Sironi F., Primignani P., Zini M., Tunesi S., Ruffmann C., Ricca S., et al. Parkin analysis in early onset Parkinson's disease. Parkinsonism Relat Disord 2008, 14:326-333.
24. Purcell S., Neale B., Todd-Brown K., Thomas L., Ferreira M.A., Bender D., et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007, 81:559-575.
25. Wang J.C., Cruchaga C., Saccone N.L., Bertelsen S., Liu P., Budde J.P., et al. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Hum Mol Genet 2009, 18:3125-3135.
26. Twelves D., Perkins K.S., Counsell C. Systematic review of incidence studies of Parkinson's disease. Mov Disord 2003, 18:19-31.
27. Haaxma C.A., Bloem B.R., Borm G.F., Oyen W.J., Leenders K.L., Eshuis S., et al. Gender differences in Parkinson's disease. J Neurol Neurosurg Psychiatr 2007, 78:819-824.
28. Latourelle J.C., Pankratz N., Dumitriu A., Wilk J.B., Goldwurm S., Pezzoli G., et al. Genomewide association study for onset age in Parkinson disease. BMC Med Genet 2009, 22(10):98.
29. Wickremaratchi M.M., Ben-Shlomo Y., Morris H.R. The effect of onset age on the clinical features of Parkinson's disease. Eur J Neurol 2009, 16:450-456.
30. Jeyarasasingam G., Tompkins L., Quik M. Stimulation of non-alpha7 nicotinic receptors partially protects dopaminergic neurons from 1-methyl-4-phenylpyridinium-induced toxicity in culture. Neuroscience 2002, 109:275-285.
31. Parain K., Hapdey C., Rousselet E., Marchand V., Dumery B., Hirsch E.C. Cigarette smoke and nicotine protect dopaminergic neurons against the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine Parkinsonian toxin. Brain Res 2003, 984:224-232.
32. Huang L.Z., Parameswaran N., Bordia T., Michael McIntosh J., Quik M. Nicotine is neuroprotective when administered before but not after nigrostriatal damage in rats and monkeys. J Neurochem 2009, 109:826-837.
33. Wang J.C., Grucza R., Cruchaga C., Hinrichs A.L., Bertelsen S., Budde J.P., et al. Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Mol Psychiatry 2009, 14:501-510.
34. Champtiaux N., Gotti C., Cordero-Erausquin M., David D.J., Przybylski C., Lena C., et al. Subunit composition of functional nicotinic receptors in dopaminergic neurons investigated with knock-out mice. J Neurosci 2003, 23:7820-7829.
35. Obeso J.A., Rodriguez-Oroz M.C., Goetz C.G., Marin C., Kordower J.H., Rodriguez M., et al. Missing pieces in the Parkinson's disease puzzle. Nat Med 2010, 16:653-661.
36. O'Reilly E.J., Chen H., Gardener H., Gao X., Schwarzschild M.A., Ascherio A. Smoking and Parkinson's disease: using parental smoking as a proxy to explore causality. Am J Epidemiol 2009, 169:678-682.