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Volumn 23, Issue 1, 2013, Pages 113-117

Evidence on the identity of the CXCR2 antagonist AZD-5069

Author keywords

AZD 5069; Chemokine; COPD; CXCR2; IL 8; Inflammation

Indexed keywords

ARD 8309; ASCORBIC ACID; AZD 5069; AZD 8309; CHEMOKINE RECEPTOR CXCR2 ANTAGONIST; DANIRIXIN; ELUBRIXIN; INTERLEUKIN 8; IODINE 125; LADARIXIN; NAVARIXIN; PYRIMIDINE DERIVATIVE; REPARIXIN; UNCLASSIFIED DRUG;

EID: 84871500153     PISSN: 13543776     EISSN: 17447674     Source Type: Journal    
DOI: 10.1517/13543776.2012.725724     Document Type: Article
Times cited : (9)

References (22)
  • 2
    • 46849120181 scopus 로고    scopus 로고
    • Phenol-containing antagonists of the CXCR2 receptor
    • DOI 10.1517/13543776.18.6.629
    • Busch-Peterson J, Wang Y. Phenol-containing antagonists of the CXCR2 receptor. Expert Opin Ther Patents 2008;18(6):629-37 (Pubitemid 351954357)
    • (2008) Expert Opinion on Therapeutic Patents , vol.18 , Issue.6 , pp. 629-637
    • Busch-Petersen, J.1    Wang, Y.2
  • 3
    • 67649425653 scopus 로고    scopus 로고
    • Chemokine receptor antagonists: Part 2
    • Pease JE, Horuk R. Chemokine receptor antagonists: part 2. Expert Opin Ther Patents 2009;19(2):199-221
    • (2009) Expert Opin Ther Patents , vol.19 , Issue.2 , pp. 199-221
    • Pease, J.E.1    Horuk, R.2
  • 4
    • 28444463303 scopus 로고    scopus 로고
    • Inflammatory mediators in chronic obstructive pulmonary disease
    • DOI 10.2174/156801005774912806
    • Chung KF. Inflammatory mediators in chronic obstructive pulmonary disease. Curr Drug Targets Inflamm Allergy 2005;4(6):619-25 (Pubitemid 41722372)
    • (2005) Current Drug Targets: Inflammation and Allergy , vol.4 , Issue.6 , pp. 619-625
    • Chung, K.F.1
  • 5
    • 43349158916 scopus 로고    scopus 로고
    • New concepts in the pathobiology of chronic obstructive pulmonary disease
    • DOI 10.1513/pats.200802-014ET
    • Kim V, Rogers TJ, Criner GJ. New concepts in the pathobiology of chronic obstructive pulmonary disease. Proc Am Thorac Soc 2008;5(4):478-85 (Pubitemid 351669174)
    • (2008) Proceedings of the American Thoracic Society , vol.5 , Issue.4 , pp. 478-485
    • Kim, V.1    Rogers, T.J.2    Criner, G.J.3
  • 8
    • 57749100072 scopus 로고    scopus 로고
    • CXCR2 antagonists for the treatment of pulmonary disease
    • Chapman RW, Phillips JE, Hipkin RW, et al. CXCR2 antagonists for the treatment of pulmonary disease. Pharmacol Ther 2009;121(1):55-68
    • (2009) Pharmacol Ther , vol.121 , Issue.1 , pp. 55-68
    • Chapman, R.W.1    Phillips, J.E.2    Hipkin, R.W.3
  • 9
    • 84858333080 scopus 로고    scopus 로고
    • Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a cxcr2 inhibitor
    • Virtala R, Ekman AK, Jansson L, et al. Airway inflammation evaluated in a human nasal lipopolysaccharide challenge model by investigating the effect of a CXCR2 inhibitor. Clin Exp Allergy 2012;42(4):590-6
    • (2012) Clin Exp Allergy , vol.42 , Issue.4 , pp. 590-596
    • Virtala, R.1    Ekman, A.K.2    Jansson, L.3
  • 10
    • 79959340752 scopus 로고    scopus 로고
    • SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans
    • Lazaar AL, Sweeney LE, MacDonald AJ, et al. SB-656933, a novel CXCR2 selective antagonist, inhibits ex vivo neutrophil activation and ozone-induced airway inflammation in humans. Br J Clin Pharmacol 2011;72(2):282-93
    • (2011) Br J Clin Pharmacol , vol.72 , Issue.2 , pp. 282-293
    • Lazaar, A.L.1    Sweeney, L.E.2    MacDonald, A.J.3
  • 11
    • 84862519263 scopus 로고    scopus 로고
    • Safety and efficacy of a cxcr2 antagonist in patients with severe asthma and sputum neutrophils: A randomized placebocontrolled
    • Nair P, Gaga M, Zervas E, et al. Safety and efficacy of a CXCR2 antagonist in patients with severe asthma and sputum neutrophils: a randomized, placebocontrolled clinical trial. Clin Exp Allergy 2012;42(7):1097-103
    • (2012) Clinical Trial. Clin Exp Allergy , vol.42 , Issue.7 , pp. 1097-1103
    • Nair, P.1    Gaga, M.2    Zervas, E.3
  • 12
    • 54349117013 scopus 로고    scopus 로고
    • Identification of a putative intracellular allosteric antagonist binding-site in the CXC chemokine receptors 1 and 2
    • Nicholls DJ, Tomkinson NP, Wiley KE, et al. Identification of a putative intracellular allosteric antagonist binding-site in the CXC chemokine receptors 1 and 2. Mol Pharmacol 2008;74(5):1193-202
    • (2008) Mol Pharmacol , vol.74 , Issue.5 , pp. 1193-1202
    • Nicholls, D.J.1    Tomkinson, N.P.2    Wiley, K.E.3
  • 13
    • 77949861512 scopus 로고    scopus 로고
    • A common intracellular allosteric binding site for antagonists of the CXCR2 receptor
    • Salchow K, BondME, Evans SC, et al. A common intracellular allosteric binding site for antagonists of the CXCR2 receptor. Br J Pharmacol 2010;159(7):1429-39
    • (2010) Br J Pharmacol , vol.159 , Issue.7 , pp. 1429-1439
    • Salchow, K.1    Bondme Evans, S.C.2
  • 14
    • 81555222803 scopus 로고    scopus 로고
    • Identification of a novel allosteric binding site in the cxcr2
    • de Kruijf P, Lim HD, Roumen L, et al. Identification of a novel allosteric binding site in the CXCR2 chemokine receptor. Mol Pharmacol 2011; 80(6):1108-18
    • (2011) Chemokine Receptor. Mol Pharmacol , vol.80 , Issue.6 , pp. 1108-1118
    • De Kruijf, P.1    Lim, H.D.2    Roumen, L.3
  • 15
    • 83755220076 scopus 로고    scopus 로고
    • Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/ CXCR2 non-competitive allosteric inhibitor
    • Bertini R, Barcelos LS, Beccari AR, et al. Receptor binding mode and pharmacological characterization of a potent and selective dual CXCR1/ CXCR2 non-competitive allosteric inhibitor. Br J Pharmacol 2012; 165(2):436-54
    • (2012) Br J Pharmacol , vol.165 , Issue.2 , pp. 436-454
    • Bertini, R.1    Barcelos, L.S.2    Beccari, A.R.3
  • 16
    • 84871492160 scopus 로고    scopus 로고
    • Nct01233232 a 4 week study to investigate the safety and tolerability of azd5069 in patients with moderate to severe chronic obstructive pulmonary disease (copd)
    • NCT01233232 A 4 Week Study to Investigate the Safety and Tolerability of AZD5069 in Patients With Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD) (CIRRUS). Available from: http://www.clinicaltrial.gov/ct2/ show/NCT01233232
    • CIRRUS
  • 20
    • 38349018273 scopus 로고    scopus 로고
    • Evaluation of a series of bicyclic CXCR2 antagonists
    • Walters I, Austin C, Austin R, et al. Evaluation of a series of bicyclic CXCR2 antagonists. Bioorg Med Chem Lett 2008;18(2):798-803
    • (2008) Bioorg Med Chem Lett , vol.18 , Issue.2 , pp. 798-803
    • Walters, I.1    Austin, C.2    Austin, R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.