Dissolution rate enhancement of loratadine in polyvinylpyrrolidone K-30 solid dispersions by solvent methods

Powder Technology

Volumn 235, Issue , 2013, Pages 532-539

  Frizon, Fernando ^a,b   Eloy, Josimar de Oliveira ^a   Donaduzzi, Carmen Maria ^b   Mitsui, Márcia Lina ^b   Marchetti, Juliana Maldonado ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b Department of Research and Development Pharmaceutical Industry Prati Donaduzzi ^*  (Brazil)

Author keywords

Loratadine; PVP K 30; Rotary evaporation; Solid dispersion; Spray drying

Indexed keywords

ACID MEDIUM; AMORPHOUS STATE; CLASS II; CLASSIFICATION SYSTEM; DISSOLUTION PROFILES; DISSOLUTION RATES; FIRST ORDER KINETICS; HYDROPHILIC MATRIX; LORATADINE; PARTICLE SIZE REDUCTION; PHYSICAL MIXTURES; POLY VINYL PYRROLIDONE; POORLY WATER-SOLUBLE DRUGS; PROTONATED; PVP K-30; ROOM TEMPERATURE; SOLID DISPERSION; SOLVENT EVAPORATION TECHNIQUES; SOLVENT METHOD; SPRAY-DRYING METHOD; SURFACE AREA; WATER SOLUBILITIES;

AUTOMOBILE MANUFACTURE; BIOCHEMISTRY; DIFFERENTIAL SCANNING CALORIMETRY; DISSOLUTION; DRYING; EVAPORATION; FOURIER TRANSFORM INFRARED SPECTROSCOPY; HYDROPHILICITY; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; PHASE TRANSITIONS; SCANNING ELECTRON MICROSCOPY; SOLUBILITY; THERMOGRAVIMETRIC ANALYSIS; X RAY DIFFRACTION;

DISPERSIONS;

DRUG CARRIER; LORATADINE; POVIDONE; SOLVENT;

ACIDITY; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DIFFERENTIAL SCANNING CALORIMETRY; DISPERSION; DRUG BIOAVAILABILITY; DRUG CLASSIFICATION; DRUG SOLUBILITY; EVAPORATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYDROPHILICITY; INFRARED SPECTROSCOPY; INTERMETHOD COMPARISON; LIGHT SCATTERING; PARTICLE SIZE; PH; PROTON TRANSPORT; ROOM TEMPERATURE; SCANNING ELECTRON MICROSCOPY; SOLID STATE; SPRAY DRYING; SURFACE PROPERTY; THERMOGRAVIMETRY; THERMOSTABILITY; X RAY DIFFRACTION;

EID: 84871488352     PISSN: 00325910     EISSN: 1873328X     Source Type: Journal    
DOI: 10.1016/j.powtec.2012.10.019     Document Type: Article

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