Relevant study on apoptosis of cervical cancer HeLa cells induced by paeoniflorin

National Medical Journal of China

Volumn 90, Issue 47, 2010, Pages 3371-3375

  Zhang, Li Li ^a   Zhang, Shu Lan ^a   Wang, Shi Zhuo ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Cell apoptosis; Cervical neoplasms; HeLa cells; Paeonia

Indexed keywords

CASPASE 3; PAEONIFLORIN; PROTEIN BAX; PROTEIN BCL 2; BAX PROTEIN, HUMAN; BENZOIC ACID DERIVATIVE; BRIDGED COMPOUND; CASP3 PROTEIN, HUMAN; GLUCOSIDE;

APOPTOSIS; ARTICLE; DOSE RESPONSE; FEMALE; FLOW CYTOMETRY; HELA CELL; HUMAN; HUMAN CELL; IC 50; IMMUNOCYTOCHEMISTRY; PROTEIN EXPRESSION; TRANSMISSION ELECTRON MICROSCOPY; UTERINE CERVIX CANCER; CELL PROLIFERATION; DRUG EFFECT; METABOLISM;

APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOIC ACIDS; BRIDGED COMPOUNDS; CASPASE 3; CELL PROLIFERATION; GLUCOSIDES; HELA CELLS; HUMANS; INHIBITORY CONCENTRATION 50; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 84871463239     PISSN: 03762491     EISSN: None     Source Type: Journal    
DOI: 10.3760/cma.j.issn.0376-2491.2010.47.017     Document Type: Article

References (14)

1. Nizamutdinova I T, Jin Y C, Kim J S, et al. Paeonol and paeoniflorin, the main active principles of Paeonia albiflora, protect the heart from myocardial ischemia/reperfusion injury in rats. Planta Med, 2008, 74: 14-18.
2. Jiang W L, Chen X G, Zhu H B, et al. Paeoniflorin inhibits systemic inflammation and improves survival in experimental sepsis. Basic Clin Pharmacol Toxicol, 2009, 105: 64-71.
3. Kim S H, Lee M K, Lee K Y, et al. Chemical constituents isolated from Paeonia lactiflora roots and their neuroprotective activity against oxidative stress in vitro. J Enzyme Inhib Med Chem, 2009, 24: 1138-1140.
4. Zhang X J, Chen H L, Li Z, et al. Analgesic effect of paeoniflorin in rats with neonatal maternal separation-induced visceral hyperalgesia is mediated through adenosine A (1) receptor by inhibiting the extracellular signal-regulated protein kinase (ERK) pathway. Pharmacol Biochem Behav, 2009, 94: 88-97.
5. Wu H, Wei W, Song L, et al. Paeoniflorin induced immune tolerance of mesenteric lymph node lymphocytes via enhancing beta 2-adrenergic receptor desensitization in rats with adjuvant arthritis. Int Immunopharmacol, 2007, 7: 662-673.
6. Wu H, Li W, Wang T S, et al. Paeoniflorin suppress NF-κB activation through modulation of IKBCI and enhances 5-fluorouracil-induced apoptosis in human gastric carcinoma cells. Biomed Pharmacother, 2008, 62: 659-666.
7. 2006, 16: 18-20.
8. Hung J Y, Yang C J, Tsai Y M, et al. Antiproliferative activity of paeoniflorin is through cell cycle arrest and the Fas/Fas ligandmediated apoptotic pathway in human non-small cell lung cancer A549 cells. Clin Exp Pharmacol Physiol, 2008, 35: 141-147.
9. Tsuboi H, Hossain K, Akhand AA, et al. Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. J Cell Biochem, 2004, 93: 162-172.
10. Zhang Y, Zhang S L. Inhibition effect of Guizhi-Fuling-decoction on the invasion of human cervical cancer. J Ethnopharmacology, 2008, 120: 25-35.
11. Xu Y, Ge R, Du J, et al. Corosolic acid induces apoptosis through mitochondrial pathway and caspase activation in human cervix adenocarcinoma HeLa cells. Cancer letter, 2009, 284: 229-237.
12. Cory S, Adams J M. The Bcl-2 family: regulators of the cellular life-or-death switch. Nat Rev Cancer, 2002, 2: 647-656.
13. Salvesen G S, Dixit V M. Caspases: Intracellular Signaling by Proteolysis. Cell, 1997, 91: 443-446.
14. Kluck R M, Bossy-Wetzel E, Green D R, et al. The release of cytochrome c from mitochondria: a primary site for Bcl-2 regulation of apoptosis. Science, 1997, 275: 1132-1136.