Chemoselective synthesis, antiproliferative activities, and SAR study of 1H-pyrazol-5-yl-N,N-dimethylformamidines and pyrazolyl-2-Azadienes

Medicinal Chemistry Research

Volumn 21, Issue 11, 2012, Pages 3920-3928

  Wen, Kau Shan ^a   Lin, Hui Yi ^a   Huang, Yu Ying ^a   Kaneko, Kimiyoshi ^a,b   Takayama, Hiroyuki ^b   Kimura, Masayuki ^b   Juang, Shin Hun ^a   Wong, Fung Fuh ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Amidination; Antiproliferative activity; Methnimidamide; Microwave Assisted reaction; Pyrazoles

Indexed keywords

5 AMINO 1 (2 CHLOROPHENYL) 3 (4 METHYLPHENYL) 1H PYRAZOLE 4 CARBALDEHYDE; 5 AMINO 1 (4 BROMOPHENYL) 3 (4 CHLOROPHENYL) 1H PYRAZOLE 4 CARBALDEHYDE; 5 AMINO 1 (4 BROMOPHENYL) 3 (4 METHYLPHENYL) 1H PYRAZOLE 4 CARBALDEHYDE; 5 AMINO 1 (4 CHLOROPHENYL) 3 (4 CHLOROPHENYL) 1H PYRAZOLE 4 CARBALDEHYDE; 5 AMINO 1,3 DIPHENYL 1H PYRAZOLE 4 CARBALDEHYDE; ALDEHYDE DERIVATIVE; ANTINEOPLASTIC AGENT; N' (4 FORMYL 1,3 DIPHENYL 1H PYRAZOL 5 YL) N,N DIMETHYL METHANIMIDAMIDE; N' [1 (2 CHLOROPHENYL) 4 FORMYL 3 (4 METHYLPHENYL) 1H PYRAZOL 5 YL] N,N DIMETHYL METHANIMIDAMIDE; N' [1 (4 BROMOPHENYL) 4 FORMYL 3 (4 CHLOROPHENYL) 1H PYRAZOL 5 YL] N,N DIMETHYL METHANIMIDAMIDE; N' [1 (4 BROMOPHENYL) 4 FORMYL 3 (4 METHYLPHENYL) 1H PYRAZOL 5 YL] N,N DIMETHYL METHANIMIDAMIDE; N' [4 FORMYL 1 (2 CHLOROPHENYL) 3 (4 CHLOROPHENYL) 1H PYRAZOL 5 YL] N,N DIMETHYL METHANIMIDAMIDE; N' [4 FORMYL 1,3 DIPHENYL 1H PYRAZOL 5 YL N,N DIMETHYL METHANIMIDAMIDE; PYRAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; LEUKEMIA CELL LINE; LUNG SMALL CELL CANCER; STRUCTURE ACTIVITY RELATION;

EID: 84871454490     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9872-1     Document Type: Article

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